GENE：ACTL6B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ACTL6B |
| FullNmae | actin like 6B |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:160 |
| EnsembleID | ENSG00000077080 |
| Uniprot | O94805 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ACTL6B | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ACTL6B | GO:0000776,GO:0000785,GO:0003682,GO:0003713,GO:0005200,GO:0005634,GO:0006325,GO:0006338,GO:0006338,GO:0006357,GO:0006357,GO:0007010,GO:0007399,GO:0008284,GO:0016358,GO:0016363,GO:0016514,GO:0016514,GO:0016514,GO:0016514,GO:0016586,GO:0030071,GO:0035060,GO:0035267,GO:0042551,GO:0043967,GO:0045582,GO:0045596,GO:0045597,GO:0045663,GO:0045893,GO:0070316,GO:0071565,GO:0071565,GO:0140092,GO:0140288,GO:1902459,GO:2000045,GO:2000781,GO:2000819 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ACTL6B | hsa:51412 | path:hsa03082 | ATP-dependent chromatin remodeling - Homo sapiens (human) |
| ACTL6B | hsa:51412 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
| ACTL6B | hsa:51412 | path:hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | ACTL6B | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | ACTL6B | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | ACTL6B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ACTL6B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ACTL6B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ACTL6B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ACTL6B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ACTL6B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | ACTL6B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ACTL6B | AFP | 25361965 | interaction type | N/A | PTMCode2 |
| AFP | ACTL6B | 25361965 | interaction type | N/A | PTMCode2 |
| ACTL6B | SMARCA2 | 25361965 | interaction type | N/A | PTMCode2 |
| SMARCA2 | ACTL6B | 25361965 | interaction type | N/A | PTMCode2 |
| ACTL6B | FLII | 25361965 | interaction type | N/A | PTMCode2 |
| FLII | ACTL6B | 25361965 | interaction type | N/A | PTMCode2 |
| ACTL6B | SMARCA4 | 25361965 | interaction type | N/A | PTMCode2 |
| SMARCA4 | ACTL6B | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CDKN1A | ACTL6B | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| TK1 | ACTL6B | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| SMN1 | ACTL6B | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| SMARCD1 | ACTL6B | 25348397 | N/A | physical interaction | ComPPI |
| CTBP1 | ACTL6B | 12565893 14525934 25348397 27898060 | N/A | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| GSK3B | ACTL6B | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| RUVBL1 | ACTL6B | 25348397 | N/A | physical interaction | ComPPI |
| PLK1 | ACTL6B | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| ATM | ACTL6B | 24234451 25348397 25640309 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| MED14 | ACTL6B | 25348397 | N/A | physical interaction | ComPPI |
| SS18 | ACTL6B | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6B | COQ9 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| ACTL6B | SMARCA2 | 12437990 14525934 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction | ComPPI,HPRD,IntAct |
| ACTL6B | CSNK2B | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| ACTL6B | ANXA7 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| ACTL6B | APP | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6B | DPF3 | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6B | DPF2 | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6B | CHRNG | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6B | H2BC1 | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6B | YEATS4 | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6B | SMARCC2 | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6B | BCL7C | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6B | BCL7A | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6B | RUVBL2 | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6B | SLC38A7 | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6B | SLC35A5 | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6B | EP400 | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6B | MAX | 25348397 | N/A | physical interaction | ComPPI |