GENE：CALML5
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CALML5 |
| FullNmae | calmodulin like 5 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:18180 |
| EnsembleID | ENSG00000178372 |
| Uniprot | Q9NZT1 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CALML5 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CALML5 | GO:0005509,GO:0005576,GO:0007165,GO:0008544,GO:0030234,GO:1904813 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CALML5 | hsa:51806 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04713 | Circadian entrainment - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04720 | Long-term potentiation - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04740 | Olfactory transduction - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04744 | Phototransduction - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04916 | Melanogenesis - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04924 | Renin secretion - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04970 | Salivary secretion - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa05012 | Parkinson disease - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa05031 | Amphetamine addiction - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa05034 | Alcoholism - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa05133 | Pertussis - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa05214 | Glioma - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
| CALML5 | hsa:51806 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | CALML5 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CALML5 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TFAP2C | CALML5 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CALML5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CALML5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | CALML5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CALML5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CALML5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CALML5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | CALML5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TBC1D22B | CALML5 | 25348397 | N/A | physical interaction | ComPPI |
| PDE4DIP | CALML5 | 25348397 | N/A | physical interaction | ComPPI |
| YJU2 | CALML5 | 25348397 | N/A | physical interaction | ComPPI |
| FTH1 | CALML5 | 25348397 | N/A | physical interaction | ComPPI |
| MCM5 | CALML5 | 25348397 | N/A | physical interaction | ComPPI |
| RAD21 | CALML5 | 25348397 | N/A | physical interaction | ComPPI |
| MCM2 | CALML5 | 25348397 | N/A | physical interaction | ComPPI |
| NF2 | CALML5 | 25348397 | N/A | physical interaction | ComPPI |
| PPP4C | CALML5 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CD81 | CALML5 | 24234451 25348397 26212323 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| COPS5 | CALML5 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA9 | CALML5 | 25348397 | N/A | physical interaction | ComPPI |
| PLK1 | CALML5 | 25348397 | N/A | physical interaction | ComPPI |
| KSR2 | CALML5 | 24234451 25348397 27086506 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| MAPK6 | CALML5 | 24234451 25348397 26972000 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| USF2 | CALML5 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| YWHAQ | CALML5 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| STK4 | CALML5 | 23386615 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| MAGED1 | CALML5 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| GCH1 | CALML5 | 25348397 | N/A | physical interaction | ComPPI |
| CALML5 | USP1 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CALML5 | PBRM1 | 25348397 | N/A | physical interaction | ComPPI |
| CALML5 | FBXW11 | 25348397 | N/A | physical interaction | ComPPI |
| CALML5 | GPR18 | 25348397 | N/A | physical interaction | ComPPI |
| CALML5 | KIR3DS1 | 25348397 | N/A | physical interaction | ComPPI |
| CALML5 | ALDH2 | 25348397 | N/A | physical interaction | ComPPI |
| CALML5 | HNRNPA1 | 25348397 | N/A | physical interaction | ComPPI |
| CALML5 | TNFRSF19 | 25348397 | N/A | physical interaction | ComPPI |
| CALML5 | SINHCAF | 25348397 | N/A | physical interaction | ComPPI |
| CALML5 | GDF5 | 25348397 | N/A | physical interaction | ComPPI |
| CALML5 | CYLD | 25348397 | N/A | physical interaction | ComPPI |
| CALML5 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| CALML5 | G3BP1 | 25348397 | N/A | physical interaction | ComPPI |
| CALML5 | SLX4 | 19596235 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| CALML5 | GABARAPL1 | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| CALML5 | LRRK2 | 24234451 24725412 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| DDX19B | CALML5 | 25348397 | N/A | physical interaction | ComPPI |
| KDM5B | CALML5 | 24234451 24937458 | association | chromatin immunoprecipitation assay | IntAct |
| MAPT | CALML5 | 24234451 26402096 | association | anti bait coimmunoprecipitation | IntAct |