GENE：CRLF2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CRLF2 |
| FullNmae | cytokine receptor like factor 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:14281 |
| EnsembleID | ENSG00000205755 |
| Uniprot | Q9HC73 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CRLF2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CRLF2 | GO:0004896,GO:0004896,GO:0004896,GO:0005576,GO:0005886,GO:0008284,GO:0008284,GO:0009897,GO:0019221,GO:0019221,GO:0019955,GO:0032754,GO:0033005,GO:0043235,GO:1904894 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CRLF2 | hsa:64109 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| CRLF2 | hsa:64109 | path:hsa04630 | JAK-STAT signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TSLP | CRLF2 | 10570284 11418668 18988627 23180781 23331499 29145629 | stimulation,physical association | fluorescence technology,inferred by curator | InnateDB,Reactome,SignaLink,SignaLink |
| STAT3 | CRLF2 | 11418668 24243840 29145629 | physical association | inferred by curator | Reactome |
| CRLF2 | JAK2 | 10872831 18988627 23331499 | stimulation | N/A | SignaLink,SignaLink |
| IL7R | CRLF2 | 10974032 23331499 | stimulation | N/A | SignaLink,SignaLink |
| CRLF2 | STAT5A | 10582086 23331499 | stimulation | N/A | SignaLink,SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| JAK2 | CRLF2 | 10872831 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| TSLP | CRLF2 | 11418668 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| CRLF2 | IL7R | 11418668 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| IL7R | CRLF2 | 10974032 11418668 27898060 | stimulant | N/A | OmniPath |
| CRLF2 | STAT5A | 10582086 27898060 | stimulant | N/A | OmniPath |
| CRLF2 | JAK2 | 10872831 27898060 | stimulant | N/A | OmniPath |
| TSLP | CRLF2 | 10570284 11418668 1141867 27898060 | stimulant | N/A | OmniPath |