GENE：HESX1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | HESX1 |
| FullNmae | HESX homeobox 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4877 |
| EnsembleID | ENSG00000163666 |
| Uniprot | Q9UBX0 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| HESX1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| HESX1 | GO:0000122,GO:0000785,GO:0000977,GO:0000978,GO:0000978,GO:0000978,GO:0000981,GO:0001227,GO:0001227,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005634,GO:0006357,GO:0007420,GO:0008406,GO:0010467,GO:0019827,GO:0021983,GO:0021983,GO:0030878,GO:0030916,GO:0035264,GO:0042803,GO:0043010,GO:0043584,GO:0045995,GO:0048853,GO:0048861,GO:0048863,GO:0060070,GO:0070371,GO:0071276,GO:1990837 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| HESX1 | hsa:8820 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CEBPA | HESX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | HESX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| OTX2 | HESX1 | 18628516 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F2 | HESX1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TLE1 | HESX1 | 11731482 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| NCOR1 | HESX1 | 11748154 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| HESX1 | NPAS2 | 25348397 | N/A | physical interaction | ComPPI |
| HESX1 | KDM1A | 23455924 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| HESX1 | PRMT6 | 23455924 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| HESX1 | STAT3 | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array,validated two hybrid | ComPPI,IntAct |
| HESX1 | UBL5 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HESX1 | HOXC8 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| HESX1 | C1ORF109 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |