GENE：NPR2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NPR2 |
| FullNmae | natriuretic peptide receptor 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7944 |
| EnsembleID | ENSG00000159899 |
| Uniprot | P20594 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NPR2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NPR2 | GO:0000165,GO:0001549,GO:0001570,GO:0001945,GO:0001958,GO:0001964,GO:0001974,GO:0002062,GO:0003417,GO:0004016,GO:0004383,GO:0004383,GO:0004383,GO:0004672,GO:0005515,GO:0005524,GO:0005525,GO:0005634,GO:0005737,GO:0005886,GO:0005886,GO:0005886,GO:0005929,GO:0006182,GO:0006182,GO:0007033,GO:0007168,GO:0007168,GO:0007168,GO:0007173,GO:0007268,GO:0007283,GO:0007605,GO:0008217,GO:0016941,GO:0016941,GO:0016941,GO:0017046,GO:0017046,GO:0019228,GO:0021647,GO:0030540,GO:0034699,GO:0035108,GO:0035112,GO:0035264,GO:0035483,GO:0035988,GO:0036342,GO:0042562,GO:0042802,GO:0043005,GO:0045202,GO:0048546,GO:0048668,GO:0048745,GO:0050872,GO:0051276,GO:0051402,GO:0051447,GO:0060385,GO:0060466,GO:0061042,GO:0061939,GO:0071321,GO:0071774,GO:0097011,GO:0097194,GO:1900194,GO:1901653,GO:1902074,GO:1903537 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NPR2 | hsa:4882 | path:hsa00230 | Purine metabolism - Homo sapiens (human) |
| NPR2 | hsa:4882 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| NPR2 | hsa:4882 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| NPR2 | hsa:4882 | path:hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| NPR2 | hsa:4882 | path:hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | NPR2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | NPR2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CTCF | NPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | NPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | NPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | NPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | NPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | NPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP3 | NPR2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NPR2 | NPPB | 25361965 | interaction type | N/A | PTMCode2 |
| NPPB | NPR2 | 25361965 | interaction type | N/A | PTMCode2 |
| NPR2 | NPPA | 25361965 | interaction type | N/A | PTMCode2 |
| NPPA | NPR2 | 25361965 | interaction type | N/A | PTMCode2 |
| NPPC | NPR2 | 25361965 | interaction type | N/A | PTMCode2 |
| NPR2 | NPPC | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NPPB | NPR2 | 25348397 | N/A | physical interaction | ComPPI |
| HSP90AB1 | NPR2 | 22939624 24234451 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
| NPPA | NPR2 | 25348397 | N/A | physical interaction | ComPPI |
| NPR2 | MOV10 | 25348397 | N/A | physical interaction | ComPPI |
| NPR2 | CDC37 | 24234451 25036637 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
| NPPC | NPR2 | 12709393 14525934 | N/A | experimental interaction detection | HPRD |
| NPR2 | NPR2 | 14525934 8765168 | N/A | experimental interaction detection | HPRD |
| NPR2 | NUMA1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| NPR3 | NPR2 | 19521502 21454883 21900499 27898060 | N/A | N/A | OmniPath |
| NPPB | NPR2 | 1309330 1660465 1672777 2570358 27898060 | stimulant | N/A | OmniPath |