GENE：PTGIR
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PTGIR |
| FullNmae | prostaglandin I2 receptor |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9602 |
| EnsembleID | ENSG00000160013 |
| Uniprot | P43119 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PTGIR | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PTGIR | GO:0005085,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0006954,GO:0007187,GO:0007189,GO:0007189,GO:0007204,GO:0007267,GO:0010642,GO:0016501,GO:0032496,GO:0048662,GO:0048662 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PTGIR | hsa:5739 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| PTGIR | hsa:5739 | path:hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| PTGIR | hsa:5739 | path:hsa04611 | Platelet activation - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FLT1 | PTGIR | 19118563 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| GATA2 | PTGIR | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | PTGIR | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| POU2F1 | PTGIR | 19118563 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| SP1 | PTGIR | 19118563 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| SPI1 | PTGIR | 19118563 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | PTGIR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PTGIR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | PTGIR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PTGIR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | PTGIR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | PTGIR | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | PTGIR | 19118563 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKCA | PTGIR | 22135298 | phosphorylation | N/A | PhosphoSite |
| GNA11 | PTGIR | 25361965 | interaction type | N/A | PTMCode2 |
| PTGIR | GNA11 | 25361965 | interaction type | N/A | PTMCode2 |
| PTGIR | GNAS | 25361965 | interaction type | N/A | PTMCode2 |
| GNAS | PTGIR | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HSPA8 | PTGIR | 25348397 | N/A | physical interaction | ComPPI |
| PDE6D | PTGIR | 14525934 16527812 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,OmniPath |
| YIPF4 | PTGIR | 25348397 | N/A | physical interaction | ComPPI |
| PRKCA | PTGIR | 14525934 25348397 9722557 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| SLC6A8 | PTGIR | 25348397 | N/A | physical interaction | ComPPI |
| SLC9A1 | PTGIR | 25348397 | N/A | physical interaction | ComPPI |
| GNAQ | PTGIR | 10446129 11443126 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| CANX | PTGIR | 25348397 | N/A | physical interaction | ComPPI |
| PKD2 | PTGIR | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | ADCY10 | 10446129 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PTGIR | GNA11 | 10446129 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| PTGIR | GNAS | 12488443 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PTGIR | LNX1 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | RAB11A | 18832025 20395296 21653824 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| PTGIR | TBXA2R | 15471868 20522800 23493750 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| PTGIR | GNAS | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | GNAS | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | PDZD3 | 22884631 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| PTGIR | RAB5A | 18498773 20395296 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| PTGIR | PDZK1P1 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | PDZK1 | 21653824 23457445 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| PTGIR | GHRL | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | SLC12A6 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | UGCG | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | PCDH10 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | FZD2 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | SLC30A1 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | ANO5 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | GJC1 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | SLC15A4 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | SLC4A2 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | GLMN | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | PDXDC1 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | SLC12A7 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | XKR8 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | STK39 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | DNAJC18 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | SLC12A9 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | EDA | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | XPR1 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | DPH6 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | MTX3 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | SLC7A2 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | SLC12A2 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | ATP11C | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | PIGN | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | TMEM63A | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | HMGCR | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | MFSD8 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | GK | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | ATP2B2 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | SLC29A1 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | DNAAF5 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | SLC47A1 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | TMEM63B | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | NR2F2 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | LRRC8E | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | TTYH3 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | STEAP3 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | TMEM179B | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | SNX14 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | FAM8A1 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | SLC25A46 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | MFAP3 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | ATG9A | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | GPAA1 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | GP1BB | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | TUBGCP2 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | ARL5B | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | ATP6V0A1 | 25348397 | N/A | physical interaction | ComPPI |
| PTGIR | OSBPL8 | 25348397 | N/A | physical interaction | ComPPI |
| PRKCA | PTGIR | 12016224 27898060 9722557 | N/A | N/A | OmniPath |