GENE：VPS33A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | VPS33A |
| FullNmae | VPS33A core subunit of CORVET and HOPS complexes |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:18179 |
| EnsembleID | ENSG00000139719 |
| Uniprot | Q96AX1 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| VPS33A | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| VPS33A | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| VPS33A | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| VPS33A | GO:0005515,GO:0005764,GO:0005765,GO:0005769,GO:0005770,GO:0005776,GO:0006886,GO:0008333,GO:0010008,GO:0016192,GO:0016192,GO:0030136,GO:0030220,GO:0030897,GO:0030897,GO:0031902,GO:0032400,GO:0032418,GO:0033263,GO:0033263,GO:0034058,GO:0035542,GO:0035751,GO:0048070,GO:0048471,GO:0097352 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| VPS33A | hsa:65082 | path:hsa04140 | Autophagy - animal - Homo sapiens (human) |
| VPS33A | hsa:65082 | path:hsa04148 | Efferocytosis - Homo sapiens (human) |
| VPS33A | hsa:65082 | path:hsa05132 | Salmonella infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | VPS33A | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | VPS33A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | VPS33A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | VPS33A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | VPS33A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | VPS33A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | VPS33A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | VPS33A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000122ED0 | VPS33A | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000003ABC4 | VPS33A | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000527B00 | VPS33A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041FA2C | VPS33A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F7766 | VPS33A | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000029EBD | VPS33A | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E1509 | VPS33A | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FC5B0 | VPS33A | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | VPS33A | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065D58 | VPS33A | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005CF5F | VPS33A | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DE669 | VPS33A | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TEKT4 | VPS33A | 25348397 | N/A | physical interaction | ComPPI |
| CDC5L | VPS33A | 20467437 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CRYAB | VPS33A | 25348397 | N/A | physical interaction | ComPPI |
| VIM | VPS33A | 25348397 | N/A | physical interaction | ComPPI |
| NTRK1 | VPS33A | 25348397 | N/A | physical interaction | ComPPI |
| SREK1 | VPS33A | 25348397 | N/A | physical interaction | ComPPI |
| RAB5A | VPS33A | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| SOX2 | VPS33A | 25348397 | N/A | physical interaction | ComPPI |
| TGFBRAP1 | VPS33A | 25348397 | N/A | physical interaction | ComPPI |
| AP3D1 | VPS33A | 25348397 | N/A | physical interaction | ComPPI |
| RAB9A | VPS33A | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| TNKS | VPS33A | 11382755 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PKNOX1 | VPS33A | 25348397 | N/A | physical interaction | ComPPI |
| TGOLN2 | VPS33A | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| FBXW11 | VPS33A | 25348397 | N/A | physical interaction | ComPPI |
| VPS33A | UVRAG | 20562859 24234451 24554770 25348397 | association,physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| VPS33A | VIPAS39 | 19109425 24234451 25348397 | colocalization,physical association | anti bait coimmunoprecipitation,physical interaction,confocal microscopy | ComPPI,IntAct |
| VPS33A | CLTB | 25348397 | N/A | physical interaction | ComPPI |
| VPS33A | STX17 | 24234451 24554770 25348397 | colocalization,association,physical association | anti tag coimmunoprecipitation,physical interaction,confocal microscopy | ComPPI,IntAct |
| YKT6 | VPS33A | 15889152 21613544 23051737 27898060 | N/A | N/A | OmniPath |