GENE：ALS2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ALS2 |
| FullNmae | alsin Rho guanine nucleotide exchange factor ALS2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:443 |
| EnsembleID | ENSG00000003393 |
| Uniprot | Q96Q42 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ALS2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ALS2 | GO:0001662,GO:0001726,GO:0001881,GO:0005085,GO:0005085,GO:0005096,GO:0005515,GO:0005634,GO:0005737,GO:0005769,GO:0005813,GO:0005813,GO:0005829,GO:0005829,GO:0006979,GO:0007032,GO:0007041,GO:0007528,GO:0007626,GO:0008104,GO:0014069,GO:0016197,GO:0030027,GO:0030425,GO:0030425,GO:0030426,GO:0031267,GO:0031267,GO:0031267,GO:0031982,GO:0032991,GO:0035022,GO:0035249,GO:0042802,GO:0042803,GO:0043087,GO:0043197,GO:0043231,GO:0043539,GO:0043547,GO:0045860,GO:0048812,GO:0051036,GO:0051260 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ALS2 | hsa:57679 | path:hsa05014 | Amyotrophic lateral sclerosis - Homo sapiens (human) |
| ALS2 | hsa:57679 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ALS2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ALS2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ALS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ALS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ALS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ALS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ALS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ALS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ALS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ALS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ALS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | ALS2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| VCP | ALS2 | 25348397 | N/A | physical interaction | ComPPI |
| RAC1 | ALS2 | 21300063 24234451 25348397 | physical association | pull down | ComPPI,IntAct |
| YWHAB | ALS2 | 14525934 15324660 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| RAB5A | ALS2 | 21300063 24234451 25348397 | physical association | pull down | ComPPI,IntAct |
| EEA1 | ALS2 | 21300063 24234451 25348397 | colocalization | fluorescence microscopy | ComPPI,IntAct |
| STXBP6 | ALS2 | 25348397 | N/A | physical interaction | ComPPI |
| NEK1 | ALS2 | 25348397 | N/A | physical interaction | ComPPI |
| CDC37 | ALS2 | 24234451 25036637 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
| ALS2 | DNAAF2 | 25348397 | N/A | physical interaction | ComPPI |
| ALS2 | SDF2 | 25348397 | N/A | physical interaction | ComPPI |
| ALS2 | CFAP410 | 25348397 | N/A | physical interaction | ComPPI |
| ALS2 | RBM6 | 25348397 | N/A | physical interaction | ComPPI |
| ALS2 | ALS2 | 21300063 24234451 | physical association | anti tag coimmunoprecipitation | IntAct |
| ALS2 | GRIP1 | 17093100 27898060 | N/A | N/A | OmniPath |