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GENE：APLP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol APLP1
FullNmae amyloid beta precursor like protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:597
EnsembleID ENSG00000105290
Uniprot P51693

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
APLP1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
APLP1 GO:0005515,GO:0005604,GO:0005654,GO:0005794,GO:0005794,GO:0005886,GO:0005886,GO:0006417,GO:0006897,GO:0006915,GO:0007155,GO:0007399,GO:0007409,GO:0007417,GO:0008201,GO:0009887,GO:0030198,GO:0030900,GO:0031694,GO:0031694,GO:0031695,GO:0031695,GO:0031696,GO:0031696,GO:0042802,GO:0046914,GO:0048471,GO:0071874,GO:0106072,GO:0180011

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 APLP1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 APLP1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
EGR1 APLP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 APLP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 APLP1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 APLP1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00005651EE APLP1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
APLP1 APBB1 25361965 interaction type N/A PTMCode2
APBB1 APLP1 25361965 interaction type N/A PTMCode2
APLP1 DAB1 25361965 interaction type N/A PTMCode2
DAB1 APLP1 25361965 interaction type N/A PTMCode2
APLP1 PRNP 25361965 interaction type N/A PTMCode2
PRNP APLP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 APLP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TMSB4X APLP1 14525934 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
VIM APLP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDKN1A APLP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SAT1 APLP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CRCT1 APLP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2C APLP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TK1 APLP1 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GLP1R APLP1 25348397 N/A physical interaction ComPPI
SMN1 APLP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DAB2 APLP1 25348397 N/A physical interaction ComPPI
SETDB1 APLP1 25348397 N/A physical interaction ComPPI
NACA APLP1 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
DAB1 APLP1 10460257 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PRNP APLP1 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
APBB1 APLP1 14525934 25348397 8894693 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
EEF1A1 APLP1 25348397 N/A physical interaction ComPPI
RAP1B APLP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RCC1 APLP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ARRB1 APLP1 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ING5 APLP1 25348397 N/A physical interaction ComPPI
HAP1 APLP1 25348397 N/A physical interaction ComPPI
UTP14A APLP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RBM48 APLP1 25348397 N/A physical interaction ComPPI
ZNF24 APLP1 14525934 16169070 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MED12 APLP1 21293490 24234451 25348397 N/A pull down ComPPI,IntAct
HSPE1 APLP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SNCA APLP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LRIF1 APLP1 25348397 N/A physical interaction ComPPI
EIF2S2 APLP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PCDHA4 APLP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GDF9 APLP1 25348397 N/A physical interaction ComPPI
STX5 APLP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MPHOSPH6 APLP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDK4 APLP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CSNK2B APLP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TSC22D1 APLP1 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MED4 APLP1 21293490 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
APLP2 APLP1 16193067 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
APBB2 APLP1 25348397 N/A physical interaction ComPPI
KAT5 APLP1 25348397 N/A physical interaction ComPPI
PNP APLP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APLP1 TCF21 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APLP1 HLA-DQA1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APLP1 PHF10 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APLP1 TOE1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APLP1 NACA 25348397 N/A physical interaction ComPPI
APLP1 NACA4P 25348397 N/A physical interaction ComPPI
APLP1 APBB3 25348397 N/A physical interaction ComPPI
APLP1 ANXA7 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
APLP1 EEF1A1P5 25348397 N/A physical interaction ComPPI
APLP1 APP 25348397 N/A anti tag coimmunoprecipitation ComPPI
APLP1 CNTN3 18272596 24234451 25348397 N/A pull down ComPPI,IntAct
APLP1 CNTN4 18272596 24234451 25348397 N/A pull down ComPPI,IntAct
APLP1 CNTN5 18272596 24234451 25348397 N/A pull down ComPPI,IntAct
APLP1 SPON1 14983046 24234451 25348397 physical association pull down ComPPI,IntAct
APLP1 FOS 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
GSTM4 APLP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
APLP1 APLP1 16193067 21930949 24234451 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,x-ray crystallography IntAct

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