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GENE：BLK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BLK
FullNmae BLK proto-oncogene, Src family tyrosine kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1057
EnsembleID ENSG00000136573
Uniprot P51451

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BLK lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
BLK lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
BLK immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
BLK GO:0004713,GO:0004715,GO:0004715,GO:0004715,GO:0005102,GO:0005515,GO:0005524,GO:0005829,GO:0006468,GO:0007169,GO:0018108,GO:0030154,GO:0031234,GO:0032024,GO:0032092,GO:0035556,GO:0045087,GO:0050853,GO:0050853

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BLK hsa:640 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BLK EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
BLK STAT3 23180781 25416956 physical association two hybrid InnateDB
BLK EFS 23180781 25416956 physical association two hybrid InnateDB
BLK CCDC33 23180781 25416956 physical association two hybrid InnateDB
IGHM BLK 12453414 1702903 29145629 7524079 7592958 7688784 7927516 8306975 enzymatic reaction inferred by curator Reactome
IGHD BLK 12453414 1702903 29145629 7524079 7592958 7688784 7927516 8306975 enzymatic reaction inferred by curator Reactome
IGKC BLK 12453414 1702903 29145629 7524079 7592958 7688784 7927516 8306975 enzymatic reaction inferred by curator Reactome
CD79B BLK 12453414 1702903 29145629 7524079 7592958 7688784 7927516 8306975 enzymatic reaction inferred by curator Reactome
CD79A BLK 12453414 1702903 29145629 7524079 7592958 7688784 7927516 8306975 enzymatic reaction inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
AR BLK 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 BLK 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC BLK 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 BLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 BLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 BLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 BLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 BLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 BLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PAX5 BLK 18697940 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
BLK FCGR2C 22135298 phosphorylation N/A PhosphoSite
BLK FCGR2A 22135298 phosphorylation N/A PhosphoSite
BLK FCGR2B 22135298 phosphorylation N/A PhosphoSite
LCP2 BLK 25361965 interaction type N/A PTMCode2
BLK LCP2 25361965 interaction type N/A PTMCode2
BLK CBL 25361965 interaction type N/A PTMCode2
CBL BLK 25361965 interaction type N/A PTMCode2
BLK EGFR 25361965 interaction type N/A PTMCode2
EGFR BLK 25361965 interaction type N/A PTMCode2
BLK BCR 25361965 interaction type N/A PTMCode2
BCR BLK 25361965 interaction type N/A PTMCode2
BLK PLCG2 25361965 interaction type N/A PTMCode2
PLCG2 BLK 25361965 interaction type N/A PTMCode2
CD79A BLK 25361965 interaction type N/A PTMCode2
BLK CD79A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BCAS2 BLK 12406557 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
ZNF774 BLK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZBTB8A BLK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SOCS3 BLK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ATP5PO BLK 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FXR2 BLK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLK CBL 14525934 24234451 25348397 8083187 8621719 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
BLK PLCG2 25348397 N/A physical interaction,in vivo ComPPI
BLK CTR9 14525934 25348397 8636124 N/A experimental interaction detection,in vitro ComPPI,HPRD
BLK FCGR2B 14525934 25348397 8756631 N/A experimental interaction detection,in vitro ComPPI,HPRD
BLK CD79A 14525934 25348397 7592958 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BLK FCGR2A 14525934 25348397 8756631 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BLK CD79B 14525934 25348397 7592958 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BLK BCR 14525934 25348397 8756631 N/A experimental interaction detection,in vivo ComPPI,HPRD
BLK BCL2 14525934 25348397 9525867 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BLK UBE3A 10449731 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BLK BCL2L1 25348397 N/A physical interaction ComPPI
BLK HSP90AA1 25348397 N/A physical interaction ComPPI
BLK HSP90AA2P 25348397 N/A physical interaction ComPPI
BLK EGFR 16273093 24234451 24658140 25348397 physical association protein array,ubiquitin reconstruction,physical interaction ComPPI,IntAct
BLK ERBB2 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
BLK STAT3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BLK EFS 24234451 25348397 25416956 physical association physical interaction,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BLK CCDC33 25348397 N/A physical interaction ComPPI
BLK ANKRD54 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK ATP5F1A 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK ATP5F1B 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK ATP5F1C 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK ATP5F1D 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK ATP5F1E 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK ATP5PB 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK ATP5PD 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK ATP5ME 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK ATP5PF 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK ATP5MF 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK ATP5MG 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK ATP5IF1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK YBX3 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK EEF1E1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK EEF2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK GAPDH 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK GNG12 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK HSP90B1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK PHB2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK SNRPD1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK ATP5MK 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK CYTIP 25348397 N/A physical interaction ComPPI
BLK A4GNT 25348397 N/A physical interaction ComPPI
BLK FAM217B 25348397 N/A physical interaction ComPPI
BLK SLC30A4 25348397 N/A physical interaction ComPPI
BLK CAMK1 25348397 N/A physical interaction ComPPI
BLK GLRA2 25348397 N/A physical interaction ComPPI
BLK GLYR1 25348397 N/A physical interaction ComPPI
BLK RNASE3 25348397 N/A physical interaction ComPPI
BLK SYCP3 25348397 N/A physical interaction ComPPI
BLK SENP1 25348397 N/A physical interaction ComPPI
BLK APBB3 25348397 N/A physical interaction ComPPI
BLK EDEM2 25348397 N/A physical interaction ComPPI
BLK SCGB1A1 25348397 N/A physical interaction ComPPI
BLK HSP90AB1 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
BLK AR 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
BLK GAB1 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
BLK KIT 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
BLK MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
BLK PKM 25348397 N/A protein kinase assay ComPPI
BLK IKZF3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLK JAKMIP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLK SSBP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLK PXN 25348397 N/A two hybrid ComPPI
BLK ZBTB42 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLK CRKL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLK PICK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLK HSF2BP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLK BIRC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLK PIK3R3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLK DDIT4L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLK TDP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BLK FLT3 24234451 28086240 N/A protein array IntAct
PAX5 BLK 10455134 27898060 stimulant N/A OmniPath
RUNX1 BLK 10455134 27898060 stimulant N/A OmniPath
BLK LCP1 10446213 27898060 N/A N/A OmniPath
BLK CEACAM1 11850617 27898060 9867848 N/A N/A OmniPath
BLK FCGR2A 22454526 27898060 8756631 N/A N/A OmniPath
BLK ITGA4 11533025 27898060 N/A N/A OmniPath
BLK F3 12920028 15039423 27898060 N/A N/A OmniPath
BLK BCKDHA 12812918 27898060 N/A N/A OmniPath
BLK MYF5 27898060 9461343 N/A N/A OmniPath
BLK FCGR2B 27898060 8756631 stimulant N/A OmniPath
BLK MYL4 11557734 27898060 N/A N/A OmniPath

Visualization










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