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GENE：C4A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol C4A
FullNmae complement C4A (Chido/Rodgers blood group)
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1323
EnsembleID ENSG00000244731
Uniprot P0C0L4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
C4A mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
C4A immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
C4A GO:0001849,GO:0004866,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005788,GO:0005886,GO:0006954,GO:0006956,GO:0006956,GO:0006958,GO:0030424,GO:0030425,GO:0043025,GO:0045087,GO:0045202,GO:0070062,GO:0072562,GO:2000427

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
C4A hsa:720 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
C4A hsa:720 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
C4A hsa:720 path:hsa05133 Pertussis - Homo sapiens (human)
C4A hsa:720 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
C4A hsa:720 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
C4A hsa:720 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MASP2 C4A 22949645 23180781 physical association x-ray crystallography InnateDB
C1S C4A 22949645 23180781 cleavage reaction,physical association surface plasmon resonance,cleavage assay InnateDB
CTSL C4A 23180781 24315997 physical association protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
GATA1 C4A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 C4A 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 C4A 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SP1 C4A 9574539 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 C4A 9574539 trascriptional regulation,stimulation inferred by curator TFlink
NFIC C4A N/A trascriptional regulation,stimulation inferred by curator TFlink
USF1 C4A N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
NRIP1 C4A 24234451 25348397 26153859 physical association cross-linking study ComPPI,IntAct
TAF9 C4A 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
MCM2 C4A 25348397 N/A physical interaction ComPPI
APOA2 C4A 14525934 25348397 27898060 7518568 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
TLE3 C4A 24234451 25348397 26153859 physical association cross-linking study ComPPI,IntAct
OCLN C4A 25348397 N/A physical interaction ComPPI
APC C4A 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PVR C4A 25348397 N/A physical interaction ComPPI
CCL5 C4A 25348397 N/A physical interaction ComPPI
C4A CR1 14525934 25348397 27898060 8422437 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
C4A CST3 14525934 2304899 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
C4A C3AR1 14525934 25348397 27898060 9725198 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
C4A C5AR2 11773063 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
C4A C2 25348397 N/A physical interaction ComPPI
C4A ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
C4A FN1 25348397 N/A physical interaction ComPPI
C4A GDPD1 25348397 N/A physical interaction ComPPI
C4A LGALS8 25348397 N/A physical interaction ComPPI
C4A SCN2B 25348397 N/A physical interaction ComPPI
C4A TMEM89 25348397 N/A physical interaction ComPPI
C4A KIF22 25348397 N/A physical interaction ComPPI
C4A SNX27 25348397 N/A physical interaction ComPPI
C4A SLC15A1 25348397 N/A physical interaction ComPPI
C4A FAM171B 25348397 N/A physical interaction ComPPI
C4A LAMP1 25348397 N/A physical interaction ComPPI
C4A VSIG1 25348397 N/A physical interaction ComPPI
C4A ATP2B2 25348397 N/A physical interaction ComPPI
C4A MYC 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
C4A ESR1 24234451 25348397 26153859 physical association cross-linking study ComPPI,IntAct
C4A GATA3 24234451 25348397 26153859 physical association cross-linking study ComPPI,IntAct
C4A GRHL2 24234451 25348397 26153859 physical association cross-linking study ComPPI,IntAct
C4A PGR 24234451 25348397 26153859 physical association cross-linking study ComPPI,IntAct
C4A TRPS1 24234451 25348397 26153859 physical association cross-linking study ComPPI,IntAct
C4A C4BPA 12893820 14525934 N/A experimental interaction detection HPRD
METTL3 C4A 24234451 29507755 association anti tag coimmunoprecipitation IntAct
WTAP C4A 24234451 29507755 association anti tag coimmunoprecipitation IntAct
METTL14 C4A 24234451 29507755 association anti tag coimmunoprecipitation IntAct

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