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GENE：C4B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol C4B
FullNmae complement C4B (Chido/Rodgers blood group)
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1324
EnsembleID ENSG00000224389
Uniprot P0C0L5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
C4B immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
C4B GO:0001848,GO:0004866,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005886,GO:0006954,GO:0006956,GO:0006956,GO:0006958,GO:0008228,GO:0030246,GO:0030424,GO:0030425,GO:0032490,GO:0045087,GO:0045202,GO:0070062,GO:0072562,GO:0106139,GO:2000427

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
C4B hsa:721 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
C4B hsa:721 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
C4B hsa:721 path:hsa05133 Pertussis - Homo sapiens (human)
C4B hsa:721 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
C4B hsa:721 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
C4B hsa:721 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MASP2 C4B 11527969 23180781 cleavage reaction protease assay InnateDB
C1S C4B 23180781 9422791 cleavage reaction protease assay InnateDB
C2 C4B 11341920 23180781 physical association surface plasmon resonance InnateDB
CD46 C4B 23180781 8666815 physical association solid phase assay InnateDB
CFI C4B 1386357 23180781 protein cleavage protease assay InnateDB
PITX3 C4B 22278372 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 C4B 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 C4B 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SP1 C4B 9574539 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 C4B 9574539 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
C4BPA C4B 25361965 interaction type N/A PTMCode2
C4B C4BPA 25361965 interaction type N/A PTMCode2
C2 C4B 25361965 interaction type N/A PTMCode2
C4B C2 25361965 interaction type N/A PTMCode2
CD46 C4B 25361965 interaction type N/A PTMCode2
C4B CD46 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MCM2 C4B 25348397 N/A physical interaction ComPPI
KIF22 C4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation ComPPI,IntAct
C4B C2 25348397 N/A physical interaction ComPPI
C4B EEF1A1 10851272 27898060 N/A N/A OmniPath

Visualization










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