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GENE：APEX1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol APEX1
FullNmae apurinic/apyrimidinic endodeoxyribonuclease 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:587
EnsembleID ENSG00000100823
Uniprot P27695

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
APEX1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
APEX1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
APEX1 GO:0000723,GO:0000781,GO:0003677,GO:0003684,GO:0003691,GO:0003713,GO:0003714,GO:0003723,GO:0003906,GO:0003906,GO:0003906,GO:0004519,GO:0004520,GO:0004523,GO:0004528,GO:0004844,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005783,GO:0005813,GO:0005840,GO:0006281,GO:0006284,GO:0006284,GO:0006287,GO:0006308,GO:0006310,GO:0008081,GO:0008081,GO:0008296,GO:0008309,GO:0008311,GO:0008408,GO:0008408,GO:0016491,GO:0016607,GO:0016890,GO:0031490,GO:0042981,GO:0043488,GO:0045454,GO:0045892,GO:0045944,GO:0046872,GO:0048471,GO:0052720,GO:0080111,GO:0090580,GO:0097698,GO:0140431

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
APEX1 hsa:328 path:hsa03410 Base excision repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APEX1 TRAF2 17599408 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
APEX1 ALOX5 17018618 23180781 physical association electrophoretic mobility shift assay InnateDB
APEX1 GZMA 12524539 23180781 protein cleavage,physical association anti tag coimmunoprecipitation,protease assay InnateDB
APEX1 STAT3 15735682 23180781 physical association anti tag coimmunoprecipitation InnateDB
SRPK1 APEX1 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 APEX1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC APEX1 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYCN APEX1 16093321 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 APEX1 18208837 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 APEX1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 APEX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 APEX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 APEX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS APEX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF APEX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR APEX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A APEX1 19524065 trascriptional regulation,stimulation inferred by curator TFlink
SP1 APEX1 18208837 7534297 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 APEX1 18208837 7534297 trascriptional regulation,stimulation inferred by curator TFlink
SSB APEX1 11781104 trascriptional regulation,stimulation inferred by curator TFlink
USF1 APEX1 7534297 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 APEX1 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A APEX1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000033EBB8 APEX1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002367FA APEX1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B APEX1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000157026 APEX1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA APEX1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001B341F APEX1 20371350 22473208 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001597DC APEX1 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000072B4C8 APEX1 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001DABC0 APEX1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005F9738 APEX1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005651EE APEX1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002D349B APEX1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000021D08 APEX1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D2F5 APEX1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5E03 APEX1 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B APEX1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000330617 APEX1 20371350 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 APEX1 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002971AB APEX1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000BE495 APEX1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000585553 APEX1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
APEX1 XRCC1 25361965 interaction type N/A PTMCode2
XRCC1 APEX1 25361965 interaction type N/A PTMCode2
APEX1 TP53 25361965 interaction type N/A PTMCode2
TP53 APEX1 25361965 interaction type N/A PTMCode2
APEX1 GZMA 25361965 interaction type N/A PTMCode2
GZMA APEX1 25361965 interaction type N/A PTMCode2
APEX1 FEN1 25361965 interaction type N/A PTMCode2
FEN1 APEX1 25361965 interaction type N/A PTMCode2
APEX1 HIF1A 25361965 interaction type N/A PTMCode2
HIF1A APEX1 25361965 interaction type N/A PTMCode2
APEX1 SET 25361965 interaction type N/A PTMCode2
SET APEX1 25361965 interaction type N/A PTMCode2
APEX1 TXN 25361965 interaction type N/A PTMCode2
TXN APEX1 25361965 interaction type N/A PTMCode2
APEX1 HSPA1A 25361965 interaction type N/A PTMCode2
HSPA1A APEX1 25361965 interaction type N/A PTMCode2
APEX1 PCNA 25361965 interaction type N/A PTMCode2
PCNA APEX1 25361965 interaction type N/A PTMCode2
NME1 APEX1 25361965 interaction type N/A PTMCode2
APEX1 NME1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPK APEX1 25348397 N/A physical interaction ComPPI
UBE2I APEX1 12110916 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
TFAP4 APEX1 25348397 N/A physical interaction ComPPI
MORF4L2 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
KPNA3 APEX1 25348397 N/A physical interaction ComPPI
EIF1B APEX1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PAK2 APEX1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NPM1 APEX1 25348397 N/A physical interaction ComPPI
PCNA APEX1 10559261 11601988 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
POLB APEX1 14525934 17803946 24234451 25348397 9207062 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
SET APEX1 12524539 12628186 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TRAF6 APEX1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SNRPD1 APEX1 25348397 N/A physical interaction ComPPI
MCM5 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
MCM6 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
MCM2 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
CGGBP1 APEX1 25348397 N/A physical interaction ComPPI
PRKDC APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
JUN APEX1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
HMGA1 APEX1 25348397 N/A filter binding,physical interaction ComPPI
EP300 APEX1 14525934 14633989 20808282 20856196 24234451 25348397 acetylation reaction,association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,acetylase assay ComPPI,HPRD,IntAct
HIF1A APEX1 10594042 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
HDAC3 APEX1 25348397 N/A physical interaction ComPPI
SFPQ APEX1 25348397 N/A physical interaction ComPPI
NTRK1 APEX1 25348397 N/A physical interaction ComPPI
RUVBL1 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
YBX1 APEX1 20856196 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XRCC1 APEX1 11707423 14525934 19934257 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct,OmniPath
BUB3 APEX1 25348397 N/A physical interaction ComPPI
XRCC5 APEX1 25348397 N/A physical interaction ComPPI
HSPA1A APEX1 10629618 11133992 14525934 20808282 24234451 25348397 27898060 association,physical association affinity chromatography technology,coimmunoprecipitation,experimental interaction detection,pull down ComPPI,HPRD,IntAct,OmniPath
HSPA1B APEX1 25348397 N/A pull down ComPPI
RPA1 APEX1 25348397 N/A physical interaction ComPPI
FEN1 APEX1 11601988 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MUTYH APEX1 11092888 14525934 19820168 24209961 24234451 25348397 27898060 N/A experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct,OmniPath
GZMA APEX1 12524539 12555094 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TXN APEX1 10585464 11118054 14525934 24234451 25348397 8736558 9108029 N/A experimental interaction detection,physical interaction,solution state nmr ComPPI,HPRD,IntAct
EEF1A1 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
HNRNPL APEX1 11809897 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
ANP32A APEX1 12524539 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
HMGB1 APEX1 17803946 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
EIF6 APEX1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PABPC1 APEX1 25348397 N/A physical interaction ComPPI
RPA2 APEX1 25348397 N/A physical interaction ComPPI
RPA3 APEX1 25348397 N/A physical interaction ComPPI
ORC2 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
CCNA1 APEX1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MORF4L1 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
TRAF2 APEX1 25348397 N/A physical interaction ComPPI
ABCE1 APEX1 25348397 N/A physical interaction ComPPI
ARF6 APEX1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SRPK1 APEX1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
NAE1 APEX1 25348397 N/A physical interaction ComPPI
WDR77 APEX1 25348397 N/A physical interaction ComPPI
MDM2 APEX1 25348397 N/A physical interaction ComPPI
SYNCRIP APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
EGFR APEX1 24234451 24780295 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HDAC2 APEX1 25348397 N/A physical interaction ComPPI
TCP1 APEX1 25348397 N/A physical interaction ComPPI
POLR3D APEX1 25348397 N/A physical interaction ComPPI
SIRT1 APEX1 19934257 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,deacetylase assay,fluorescence microscopy ComPPI,IntAct
ELOC APEX1 25348397 N/A physical interaction ComPPI
PRDX6 APEX1 25348397 N/A physical interaction ComPPI
PRKN APEX1 25348397 N/A physical interaction ComPPI
HNRNPUL1 APEX1 25348397 N/A physical interaction ComPPI
RNF4 APEX1 25348397 N/A physical interaction ComPPI
HNRNPR APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
HMGA2 APEX1 25348397 N/A physical interaction ComPPI
DDB1 APEX1 25348397 N/A physical interaction ComPPI
SRPK2 APEX1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
MRE11 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
RAD50 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
ILF2 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
TERF1 APEX1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
RIC8A APEX1 25348397 N/A physical interaction ComPPI
TXNRD1 APEX1 25348397 N/A physical interaction ComPPI
XPOT APEX1 25348397 N/A physical interaction ComPPI
MCM3 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
MCM4 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
BRCA1 APEX1 25348397 N/A physical interaction ComPPI
METTL1 APEX1 25348397 N/A physical interaction ComPPI
STAT3 APEX1 25348397 N/A physical interaction ComPPI
TERF2 APEX1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
TERF2IP APEX1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
CAPNS1 APEX1 25348397 N/A physical interaction ComPPI
EEF2 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
PRPF19 APEX1 25348397 N/A physical interaction ComPPI
RUVBL2 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
GADD45A APEX1 25348397 N/A physical interaction ComPPI
MCM7 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
FCGR2A APEX1 25348397 N/A physical interaction ComPPI
KRT8 APEX1 25348397 N/A physical interaction ComPPI
RPSA APEX1 25348397 N/A physical interaction ComPPI
ILF3 APEX1 20808282 24234451 25348397 association affinity chromatography technology ComPPI,IntAct
ARIH2 APEX1 25348397 N/A physical interaction ComPPI
LGALS1 APEX1 25348397 N/A physical interaction ComPPI
MCC APEX1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NUDT3 APEX1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HOXC13 APEX1 25348397 N/A physical interaction ComPPI
TCF21 APEX1 25348397 N/A physical interaction ComPPI
TWF2 APEX1 25348397 N/A physical interaction ComPPI
APP APEX1 25348397 N/A physical interaction ComPPI
TP53 APEX1 14525934 25348397 9119221 N/A experimental interaction detection,physical interaction ComPPI,HPRD
NXF1 APEX1 25348397 N/A physical interaction ComPPI
HDAC1 APEX1 14525934 14633989 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
HLA-B APEX1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PAPSS2 APEX1 25348397 N/A physical interaction ComPPI
G3BP1 APEX1 25348397 N/A physical interaction ComPPI
OTUB1 APEX1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
APEX1 GZMK 25348397 N/A physical interaction ComPPI
APEX1 CCDC124 25348397 N/A physical interaction ComPPI
APEX1 PSMG1 25348397 N/A physical interaction ComPPI
APEX1 KLHL36 25348397 N/A physical interaction ComPPI
APEX1 CFAP74 25348397 N/A physical interaction ComPPI
APEX1 OTUD6B 25348397 N/A physical interaction ComPPI
APEX1 CLVS2 25348397 N/A physical interaction ComPPI
APEX1 PDE12 25348397 N/A physical interaction ComPPI
APEX1 UBR3 25348397 N/A physical interaction ComPPI
APEX1 SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CSNK2A1 APEX1 10023679 14525934 N/A experimental interaction detection HPRD
XRCC6 APEX1 14525934 27898060 8621488 N/A experimental interaction detection HPRD,OmniPath
NME1 APEX1 12524539 14525934 N/A experimental interaction detection HPRD
HMGB2 APEX1 12524539 14525934 N/A experimental interaction detection HPRD
APEX1 ANP32C 12524539 14525934 N/A experimental interaction detection HPRD
DCTN1 APEX1 14525934 9361024 N/A experimental interaction detection,two hybrid HPRD
APEX1 APEX1 14525934 9108029 N/A experimental interaction detection HPRD
METTL14 APEX1 24234451 29507755 association anti tag coimmunoprecipitation IntAct
APEX1 NPY2R 24234451 30021884 physical association cross-linking study IntAct
APEX1 TRAF2 17599408 27898060 N/A N/A OmniPath
TRAF2 APEX1 17599408 27898060 N/A N/A OmniPath
RECQL4 APEX1 19567405 27898060 stimulant N/A OmniPath
GAPDH APEX1 18776186 27898060 stimulant N/A OmniPath
APEX1 TXN 10585464 11118054 18586825 27898060 8736558 9108029 stimulant N/A OmniPath
SIRT1 APEX1 19934257 27898060 stimulant N/A OmniPath
APEX1 FOSL1 18786561 27898060 stimulant N/A OmniPath
APEX1 TP53 15824742 19180539 19737086 27898060 9119221 stimulant N/A OmniPath
GZMA APEX1 12524539 12555094 27898060 inhibition,stimulant N/A OmniPath
EP300 APEX1 14633989 19934257 20808282 20856196 27898060 N/A N/A OmniPath
APEX1 CCNO 18259689 27898060 stimulant N/A OmniPath
ERCC6 APEX1 17567611 27898060 inhibition N/A OmniPath
APEX1 STAT3 15735682 20032196 27898060 stimulant N/A OmniPath
STAT3 APEX1 15735682 20032196 27898060 N/A N/A OmniPath
APEX1 ARNT 10671489 27898060 stimulant N/A OmniPath
APEX1 RELB 19180539 19737086 27898060 stimulant N/A OmniPath

Visualization










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