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GENE：CLPB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CLPB
FullNmae ClpB family mitochondrial disaggregase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30664
EnsembleID ENSG00000162129
Uniprot Q9H078

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CLPB immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CLPB GO:0003674,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005758,GO:0005758,GO:0016887,GO:0016887,GO:0030851,GO:0034605,GO:0034605,GO:0039529,GO:0140374,GO:0140545,GO:0140545

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CLPB hsa:81570 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 CLPB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CLPB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CLPB 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A CLPB 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SMARCA4 CLPB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CLPB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CLPB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CLPB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CLPB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CLPB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CLPB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CLPB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CLPB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CLPB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 CLPB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CLPB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CLPB 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000005481D CLPB 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002AAD6B CLPB 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002AA55A CLPB 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000292B1 CLPB 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001938D9 CLPB 22012620 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000AA464 CLPB 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000367985 CLPB 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000055BBE5 CLPB 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000171525 CLPB 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000012A1DD CLPB 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 CLPB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A CLPB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 CLPB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000043C1C3 CLPB 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 CLPB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C CLPB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC4BD CLPB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000BD6DC CLPB 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000009EA8F CLPB 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000ECE9C CLPB 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004E02F2 CLPB 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000004BACE CLPB 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000001A7A CLPB 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001012BC CLPB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005586D0 CLPB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F CLPB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000027352D CLPB 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A608 CLPB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 CLPB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 CLPB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D CLPB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 CLPB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD CLPB 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000017DBB8 CLPB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000018CD09 CLPB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000482389 CLPB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001A4ABF CLPB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 CLPB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001DABC0 CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C770D CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000029D793 CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000019907A CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000137EDE CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000032AE90 CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000237E04 CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003B59DF CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000B989F CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C5969 CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003E5ECC CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004CCA62 CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C1E1 CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005194EC CLPB 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000013E79D CLPB 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001CF056 CLPB 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
KEAP1 CLPB 25348397 N/A physical interaction ComPPI
MCM2 CLPB 25348397 N/A physical interaction ComPPI
MDFI CLPB 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach ComPPI,IntAct
PAK5 CLPB 25348397 N/A physical interaction ComPPI
EIF5 CLPB 25348397 N/A physical interaction ComPPI
PAG1 CLPB 25348397 N/A physical interaction ComPPI
SETDB1 CLPB 25348397 N/A physical interaction ComPPI
CUL3 CLPB 25348397 N/A physical interaction ComPPI
IRS4 CLPB 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARFIP1 CLPB 25348397 N/A physical interaction ComPPI
NTRK1 CLPB 25348397 N/A physical interaction ComPPI
SMAD9 CLPB 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SQSTM1 CLPB 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
XPO1 CLPB 25348397 N/A physical interaction ComPPI
CLPB COPS6 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLPB UCHL3 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLPB OSBPL10 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLPB TERF2 25348397 N/A physical interaction ComPPI
CLPB CEP70 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CLPB ERCC6L 25348397 N/A physical interaction ComPPI
CLPB OGA 25348397 N/A physical interaction ComPPI
CLPB NDUFA4 25348397 N/A physical interaction ComPPI
CLPB COQ8A 25348397 N/A physical interaction ComPPI
CLPB NDUFS3 25348397 N/A physical interaction ComPPI
CLPB CDKN3 25348397 N/A physical interaction ComPPI
CLPB TRIM11 25348397 N/A physical interaction ComPPI
CLPB MDM2 25348397 N/A physical interaction ComPPI
CLPB NAP1L5 25348397 N/A physical interaction ComPPI
CLPB UVRAG 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CLPB RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
CLPB AIFM1 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
CLPB SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPB SFXN1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CLPB OXCT1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
CLPB ECI2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
CLPB COX6B1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
COX4I1 CLPB 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct

Visualization










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