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GENE：CRYAA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CRYAA
FullNmae crystallin alpha A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2388
EnsembleID ENSG00000160202
Uniprot P02489

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CRYAA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CRYAA GO:0002088,GO:0005198,GO:0005212,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0007601,GO:0009408,GO:0032387,GO:0032991,GO:0042026,GO:0042802,GO:0043066,GO:0043066,GO:0043066,GO:0046872,GO:0050821,GO:0051082,GO:0051082,GO:0051082

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CRYAA hsa:1409 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 CRYAA 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CRYAA 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 CRYAA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CRYAA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
EGR1 CRYAA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CRYAA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CRYAA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CRYAA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CRYAA 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 CRYAA 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000003ABC4 CRYAA 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
CRYAB CRYAA 25361965 interaction type N/A PTMCode2
CRYAA CRYAB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CRYAA CRYAB 11700327 12601044 14525934 16142923 16760894 17260942 18401461 18639655 19651604 22085609 22153508 22427585 23188086 24234451 25348397 25416956 25694240 25910212 27898060 association,physical association anti bait coimmunoprecipitation,beta lactamase complementation,two hybrid,coimmunoprecipitation,transmission electron microscopy,cosedimentation in solution,dynamic light scattering,experimental interaction detection,mass spectrometry studies of complexes,molecular sieving,nuclear magnetic resonance,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct,OmniPath
CRYAA BCL2L1 14525934 14752512 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CRYAA CS 11377425 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CRYAA CRYBB2 11700327 12601044 14525934 24234451 25348397 association,physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
CRYAA CRYGC 11700327 12601044 14525934 15322286 24234451 25348397 27898060 association,physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
CRYAA CRYZ 11672428 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CRYAA MIP 14525934 25348397 27898060 8910261 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
CRYAA HSPB1 11700327 12601044 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CRYAA ALB 14525934 25348397 27898060 9618718 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CRYAA CRYAA2 25348397 N/A physical interaction ComPPI
CRYAA CRYGD 25348397 N/A physical interaction ComPPI
CRYAA HSPB2 25348397 N/A physical interaction ComPPI
CRYAA BAX 25348397 N/A physical interaction ComPPI
CRYAA CRYBA1 25348397 N/A physical interaction ComPPI
CRYAA SDCBP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CRYAA GORASP2 24234451 25348397 25416956 physical association physical interaction,mammalian protein protein interaction trap,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CRYAA SPG21 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CRYAA NTAQ1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CRYAA CRYAA 11700327 12601044 14525934 19651604 22085609 24234451 25416956 physical association anti bait coimmunoprecipitation,two hybrid,transmission electron microscopy,cosedimentation in solution,dynamic light scattering,experimental interaction detection,molecular sieving,two hybrid array,two hybrid prey pooling approach HPRD,IntAct
LALBA CRYAA 14525934 9346914 N/A experimental interaction detection HPRD
PPP3CA CRYAA 2548498 27898060 N/A N/A OmniPath
SRC CRYAA 12060738 27898060 N/A N/A OmniPath
MAF CRYAA 10603348 27898060 stimulant N/A OmniPath
PPP2CA CRYAA 11295434 27898060 N/A N/A OmniPath
PPP3CB CRYAA 2548498 27898060 N/A N/A OmniPath
PPP3CC CRYAA 2548498 27898060 N/A N/A OmniPath
CRYAA CRYBB2 11700327 12601044 22982024 27898060 stimulant N/A OmniPath
PPP2CB CRYAA 11295434 27898060 N/A N/A OmniPath

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