Gene Information gene info

  1. Home

GENE：BID

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BID
FullNmae BH3 interacting domain death agonist
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1050
EnsembleID ENSG00000015475
Uniprot P55957

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BID parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BID necroptosis 21738214 Employing mouse embryonic knockout cells, we reveal that BID controls BAX activation in AIF-mediated necroptosis. retulator signature
BID necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
BID mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BID mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BID immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BID ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BID apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BID apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BID GO:0001836,GO:0005123,GO:0005515,GO:0005739,GO:0005741,GO:0005741,GO:0005829,GO:0005829,GO:0005829,GO:0006626,GO:0006919,GO:0008625,GO:0008637,GO:0010918,GO:0016020,GO:0031334,GO:0031625,GO:0042129,GO:0042770,GO:0042775,GO:0043065,GO:0050678,GO:0051402,GO:0065003,GO:0090150,GO:0090200,GO:0090200,GO:0090200,GO:0090200,GO:0097284,GO:0097345,GO:0097435,GO:1902230,GO:2000045,GO:2000271,GO:2001238,GO:2001238,GO:2001244,GO:2001244

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BID hsa:637 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
BID hsa:637 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
BID hsa:637 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
BID hsa:637 path:hsa04210 Apoptosis - Homo sapiens (human)
BID hsa:637 path:hsa04215 Apoptosis - multiple species - Homo sapiens (human)
BID hsa:637 path:hsa04217 Necroptosis - Homo sapiens (human)
BID hsa:637 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
BID hsa:637 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
BID hsa:637 path:hsa05010 Alzheimer disease - Homo sapiens (human)
BID hsa:637 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
BID hsa:637 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
BID hsa:637 path:hsa05152 Tuberculosis - Homo sapiens (human)
BID hsa:637 path:hsa05160 Hepatitis C - Homo sapiens (human)
BID hsa:637 path:hsa05161 Hepatitis B - Homo sapiens (human)
BID hsa:637 path:hsa05162 Measles - Homo sapiens (human)
BID hsa:637 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
BID hsa:637 path:hsa05164 Influenza A - Homo sapiens (human)
BID hsa:637 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
BID hsa:637 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
BID hsa:637 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
BID hsa:637 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
BID hsa:637 path:hsa05200 Pathways in cancer - Homo sapiens (human)
BID hsa:637 path:hsa05416 Viral myocarditis - Homo sapiens (human)
BID hsa:637 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HIF1A BID 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 26192618 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622 interaction type N/A ACSN
E2F1 BID 12402042 15024076 15240700 15279786 17218262 17303408 17660363 18590585 26192618 7575488 interaction type N/A ACSN
GZMB BID 10364179 10805722 11062502 11085742 11085743 11287608 11583622 11832478 14499263 15536084 15607806 15637055 15713684 16106370 18287025 20189481 24248158 24795729 26192618 8432729 9727492 interaction type N/A ACSN
CAPN1 BID 11404357 11940658 17264306 18469004 19931333 26192618 interaction type N/A ACSN
CAPN2 BID 11404357 11940658 17264306 18469004 21887410 23242420 26192618 interaction type N/A ACSN
CTSB BID 10364179 10805722 11085742 11085743 11832478 12776207 16237087 16966373 17670831 18955971 26192618 9727492 interaction type N/A ACSN
CTSD BID 10364179 10805722 11085742 11085743 11832478 12776207 16237087 18955971 22439866 26192618 9727492 interaction type N/A ACSN
BID CASP8 18458084 23180781 cleavage reaction protease assay InnateDB
BID GZMB 10805722 11696597 12808108 15014070 15569669 16415351 17179148 17283187 19103589 23180781 protein cleavage protease assay InnateDB
BID GZMH 17765974 23180781 protein cleavage protease assay InnateDB
BID NOD1 21552281 23180781 physical association anti tag coimmunoprecipitation InnateDB
BID NOD2 21552281 23180781 physical association anti tag coimmunoprecipitation InnateDB
BID CHUK 21552281 23180781 physical association anti tag coimmunoprecipitation InnateDB
BID IKBKB 21552281 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKG BID 21552281 23180781 physical association anti tag coimmunoprecipitation InnateDB
BID REL 23180781 25416956 physical association two hybrid InnateDB
BID AHCYL1 23180781 25416956 physical association two hybrid InnateDB
BID BID 10629050 12242151 15574335 17289999 22464442 26467481 9727492 interaction type,bind,up-regulates,up-regulates activity,down-regulates activity N/A Signor

Source Target Pmid Interactiontype Methods Database
AR BID 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 BID 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 BID 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 BID 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BID 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BID 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 BID 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BID 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BID 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BID 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BID 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 BID 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 BID 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A BID 15024076 trascriptional regulation,stimulation inferred by curator TFlink
ZBTB16 BID 20731660 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001C770D BID 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005E6F45 BID 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 BID 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A BID 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 BID 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 BID 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 BID 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D BID 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000017EE98 BID 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 BID 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F BID 25416803 28004114 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAPK9 BID 22135298 phosphorylation N/A PhosphoSite
MAPK8 BID 22135298 phosphorylation N/A PhosphoSite
MAPK10 BID 22135298 phosphorylation N/A PhosphoSite
BCL2L1 BID 25361965 interaction type N/A PTMCode2
BID BCL2L1 25361965 interaction type N/A PTMCode2
CASP2 BID 25361965 interaction type N/A PTMCode2
BID CASP2 25361965 interaction type N/A PTMCode2
CASP10 BID 25361965 interaction type N/A PTMCode2
BID CASP10 25361965 interaction type N/A PTMCode2
CASP3 BID 25361965 interaction type N/A PTMCode2
BID CASP3 25361965 interaction type N/A PTMCode2
BAX BID 25361965 interaction type N/A PTMCode2
BID BAX 25361965 interaction type N/A PTMCode2
FADD BID 25361965 interaction type N/A PTMCode2
BID FADD 25361965 interaction type N/A PTMCode2
TNFRSF1A BID 25361965 interaction type N/A PTMCode2
BID TNFRSF1A 25361965 interaction type N/A PTMCode2
BCL2L2 BID 25361965 interaction type N/A PTMCode2
BID BCL2L2 25361965 interaction type N/A PTMCode2
BID BCL2 25361965 interaction type N/A PTMCode2
BCL2 BID 25361965 interaction type N/A PTMCode2
BID CASP8 25361965 interaction type N/A PTMCode2
CASP8 BID 25361965 interaction type N/A PTMCode2
BID FASLG 25361965 interaction type N/A PTMCode2
FASLG BID 25361965 interaction type N/A PTMCode2
BID MCL1 25361965 interaction type N/A PTMCode2
MCL1 BID 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDC5L BID 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BCL2L11 BID 23374347 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
BAG3 BID 25348397 N/A physical interaction ComPPI
VCP BID 25348397 N/A physical interaction ComPPI
BCL2L2 BID 14525934 15694340 16697956 17289999 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,HPRD,IntAct
BCL2L1 BID 14525934 15574335 15694340 16697956 24234451 25241761 25348397 physical association fluorescence polarization spectroscopy,isothermal titration calorimetry,physical interaction,proximity ligation assay,surface plasmon resonance array,two hybrid ComPPI,HPRD,IntAct
DDIT4L BID 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TLE1 BID 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
REL BID 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MAPK8 BID 25348397 N/A physical interaction ComPPI
SETDB1 BID 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP3 BID 10364179 14525934 18723680 24234451 25348397 cleavage reaction experimental interaction detection,cleavage reaction,physical interaction,protease assay ComPPI,HPRD,IntAct
RHOA BID 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
ARHGDIA BID 25348397 N/A physical interaction ComPPI
YWHAB BID 12871587 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection ComPPI,HPRD,IntAct
GAPDH BID 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CAV1 BID 21382479 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
CSNK1E BID 11583622 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,proximity ligation assay ComPPI,HPRD,IntAct
RPA1 BID 25348397 N/A physical interaction ComPPI
MCL1 BID 14525934 15637055 16697956 19074266 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,mass spectrometry study of hydrogen/deuterium exchange ComPPI,HPRD,IntAct
CASP8 BID 11085743 12097160 12196516 14525934 25348397 9727491 9727492 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TNFRSF1A BID 25348397 N/A physical interaction ComPPI
SQSTM1 BID 25348397 N/A physical interaction ComPPI
FADD BID 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
RPA2 BID 25348397 N/A physical interaction ComPPI
UBQLN2 BID 25348397 N/A physical interaction ComPPI
FASLG BID 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
ZHX1 BID 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BCL2A1 BID 11929871 14525934 16697956 24234451 25348397 N/A experimental interaction detection,fluorescence polarization spectroscopy,physical interaction ComPPI,HPRD,IntAct
ITCH BID 25348397 N/A physical interaction ComPPI
CASP10 BID 14525934 15772077 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MSN BID 25348397 N/A physical interaction ComPPI
CRMP1 BID 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RBM48 BID 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BAK1 BID 10950869 12624108 14525934 23604079 23782464 24234451 25348397 physical association anti bait coimmunoprecipitation,cosedimentation in solution,protein cross-linking with a bifunctional reagent,experimental interaction detection,nuclear magnetic resonance,physical interaction ComPPI,HPRD,IntAct
BCL2 BID 11583631 12624108 14525934 16697956 17289999 19074266 24234451 25348397 9463381 9727491 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,surface plasmon resonance,physical interaction ComPPI,HPRD,IntAct
CASP2 BID 11832478 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BAX BID 14525934 15574335 17289999 20956295 23374347 24234451 25241761 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,surface plasmon resonance,x-ray crystallography,physical interaction,proximity ligation assay,surface plasmon resonance array,two hybrid ComPPI,HPRD,IntAct
CAPN2 BID 25348397 N/A physical interaction ComPPI
TRIM25 BID 25348397 N/A physical interaction ComPPI
TNFRSF10B BID 25348397 N/A physical interaction ComPPI
FAS BID 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
EZR BID 25348397 N/A physical interaction ComPPI
ARL6IP6 BID 25348397 N/A physical interaction ComPPI
MBD5 BID 25348397 N/A physical interaction ComPPI
PLEKHM1 BID 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FCGR2A BID 25348397 N/A physical interaction ComPPI
HSD17B10 BID 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ERG28 BID 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GBP2 BID 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CRNKL1 BID 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AHCYL1 BID 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GZMB BID 11085743 14525934 25348397 9727491 N/A experimental interaction detection,physical interaction ComPPI,HPRD
NXF1 BID 25348397 N/A physical interaction ComPPI
BID TUBB2B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BID FBN3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BID MOV10 25348397 N/A physical interaction ComPPI
CSNK1A1 BID 11583622 14525934 N/A experimental interaction detection HPRD
CAPN1 BID 12000759 14525934 N/A experimental interaction detection HPRD
CSNK2A1 BID 11583622 14525934 N/A experimental interaction detection HPRD
CSNK2B BID 11583622 14525934 N/A experimental interaction detection HPRD
CSNK2A2 BID 11583622 14525934 N/A experimental interaction detection HPRD
BID BID 11805084 14525934 17289999 24234451 physical association experimental interaction detection,surface plasmon resonance HPRD,IntAct
CASP1 BID 11085743 14525934 9727491 N/A experimental interaction detection HPRD
CASP1 BID 11085743 27898060 9727491 N/A N/A OmniPath
CSNK1A1 BID 11583622 27898060 stimulant N/A OmniPath
CTSS BID 14581476 27898060 stimulant N/A OmniPath
BID BCL2L1 15574335 15694340 15721256 16697956 22464442 24814347 25241761 27898060 9727492 inhibition N/A OmniPath
BCL2L1 BID 15574335 15694340 15721256 16697956 24814347 25241761 27898060 9873064 inhibition N/A OmniPath
CTSK BID 14581476 27898060 stimulant N/A OmniPath
GZMB BID 10805722 11085742 11085743 11696597 12808108 15014070 15569669 16415351 17179148 17283187 19103589 27898060 9727491 stimulant N/A OmniPath
CTSL BID 14581476 27898060 stimulant N/A OmniPath
BCL2 BID 11583631 12624108 15520201 15694340 16697956 17289999 18835031 19074266 27898060 8918887 9463381 9727491 inhibition N/A OmniPath
CSNK1E BID 11583622 25241761 27898060 stimulant N/A OmniPath
CAPN1 BID 12000759 27898060 stimulant N/A OmniPath
ATM BID 16122425 16122426 18662573 27898060 stimulant N/A OmniPath
BID BAK1 10950869 11175253 12242151 12624108 17289999 23604079 23782464 27898060 stimulant N/A OmniPath
CAPN2 BID 12000759 27898060 stimulant N/A OmniPath
CASP2 BID 11399776 11832478 16495337 27898060 stimulant N/A OmniPath
BID CYCS 27898060 9727491 9727492 9873064 stimulant N/A OmniPath
CTSB BID 14581476 27898060 stimulant N/A OmniPath
TP53 BID 12402042 16151013 18431400 27898060 stimulant N/A OmniPath
BID AIFM1 11063743 15537572 27898060 N/A N/A OmniPath
BID CASP8 11085743 11832478 12097160 12196516 15659383 18458084 27898060 9727491 9727492 N/A N/A OmniPath
CASP8 BID 11085743 11832478 12097160 12196516 15659383 18458084 27898060 9727491 9727492 9873064 stimulant N/A OmniPath
CASP10 BID 15772077 16186808 27898060 stimulant N/A OmniPath
BID BCL2L2 15694340 16697956 27898060 inhibition N/A OmniPath
MAP2K6 BID 11583622 16122426 27898060 N/A N/A OmniPath
CTSH BID 14581476 27898060 stimulant N/A OmniPath
CSNK2A1 BID 11583622 27898060 inhibition,stimulant N/A OmniPath
BID BAX 10629050 12242151 15574335 17052454 17289999 23374347 25241761 27898060 8918887 stimulant N/A OmniPath
CSNK2B BID 11583622 27898060 stimulant N/A OmniPath
MAPK8 BID 18594987 27898060 stimulant N/A OmniPath
BID HTRA2 15153524 15475455 27898060 N/A N/A OmniPath
BID ENDOG 11452314 11753562 27898060 stimulant N/A OmniPath
BID DIABLO 11741882 11859412 27898060 N/A N/A OmniPath
BID COX5B 27898060 9727492 stimulant N/A OmniPath
CSNK2A2 BID 11583622 27898060 stimulant N/A OmniPath
MTCH2 BID 20436477 21295084 27898060 stimulant N/A OmniPath

Visualization










  Return