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GENE：EDEM1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EDEM1
FullNmae ER degradation enhancing alpha-mannosidase like protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18967
EnsembleID ENSG00000134109
Uniprot Q92611

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EDEM1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EDEM1 GO:0004571,GO:0004571,GO:0005509,GO:0005515,GO:0005783,GO:0005783,GO:0005783,GO:0005789,GO:0005975,GO:0006986,GO:0016235,GO:0030433,GO:0044322,GO:0044322,GO:0045047,GO:0051787,GO:0051787,GO:0097466,GO:1904154,GO:1904154,GO:1904380,GO:1904382,GO:1904382

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EDEM1 hsa:9695 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 EDEM1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 EDEM1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 EDEM1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 EDEM1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 EDEM1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 EDEM1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 EDEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EDEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EDEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 EDEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EDEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EDEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EDEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EDEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 EDEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 EDEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 EDEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 EDEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR EDEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 EDEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000029D9F1 EDEM1 21282569 rna interference,inhibition array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000029D9F1 EDEM1 21282569 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 EDEM1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00002FC5B0 EDEM1 20371350 21572407 22012620 22473208 23592263 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00001A405B EDEM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016FF9C EDEM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 EDEM1 21572407 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F EDEM1 21572407 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 EDEM1 21572407 22012620 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 EDEM1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000013D17D EDEM1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001919B0 EDEM1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 EDEM1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000FC8EB EDEM1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 EDEM1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 EDEM1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000195F5B EDEM1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 EDEM1 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 EDEM1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004C689A EDEM1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D EDEM1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 EDEM1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD EDEM1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
EDEM1 P4HB 25361965 interaction type N/A PTMCode2
P4HB EDEM1 25361965 interaction type N/A PTMCode2
CANX EDEM1 25361965 interaction type N/A PTMCode2
EDEM1 CANX 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PSMD14 EDEM1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DERL2 EDEM1 25348397 N/A physical interaction ComPPI
SUFU EDEM1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CANX EDEM1 12610305 14525934 17360537 21632540 22119785 24910992 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
P4HB EDEM1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC61B EDEM1 25348397 N/A physical interaction ComPPI
RHO EDEM1 25348397 N/A physical interaction ComPPI
SQSTM1 EDEM1 24664425 25348397 27898060 N/A physical interaction ComPPI,OmniPath
UBQLN2 EDEM1 25348397 N/A physical interaction ComPPI
EGFR EDEM1 25348397 N/A physical interaction ComPPI
MMS19 EDEM1 25348397 N/A physical interaction ComPPI
ASGR2 EDEM1 25348397 N/A physical interaction ComPPI
SHH EDEM1 25348397 N/A physical interaction ComPPI
HLA-B EDEM1 25348397 N/A physical interaction ComPPI
ELAVL1 EDEM1 25348397 N/A physical interaction ComPPI
SSR1 EDEM1 17380188 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DERL1 EDEM1 25348397 N/A physical interaction ComPPI
PNISR EDEM1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EDEM1 BZW1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EDEM1 SEL1L 19524542 21632540 24910992 25348397 27898060 N/A physical interaction ComPPI,OmniPath
EDEM1 DNAJC10 25348397 N/A physical interaction ComPPI
EDEM1 ASGR1 25348397 N/A physical interaction ComPPI
EDEM1 ESYT1 25348397 N/A physical interaction ComPPI
EDEM1 MTCH1 25348397 N/A physical interaction ComPPI
EDEM1 ZACN 25348397 N/A physical interaction ComPPI
EDEM1 NAAA 25348397 N/A physical interaction ComPPI
EDEM1 ACSL4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EDEM1 CHD9 25348397 N/A physical interaction ComPPI
EDEM1 PHF6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EDEM1 MPPE1 25348397 N/A physical interaction ComPPI
EDEM1 LOXL3 25348397 N/A physical interaction ComPPI
EDEM1 LYZL2 25348397 N/A physical interaction ComPPI
EDEM1 LYZL1 25348397 N/A physical interaction ComPPI
EDEM1 GALNT6 25348397 N/A physical interaction ComPPI

Visualization










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