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GENE：BRCA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BRCA2
FullNmae BRCA2 DNA repair associated
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1101
EnsembleID ENSG00000139618
Uniprot P51587

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BRCA2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BRCA2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BRCA2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BRCA2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BRCA2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BRCA2 GO:0000152,GO:0000722,GO:0000724,GO:0000724,GO:0000724,GO:0000781,GO:0000800,GO:0001556,GO:0001833,GO:0002020,GO:0003697,GO:0005515,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005813,GO:0005829,GO:0005829,GO:0006289,GO:0006302,GO:0006338,GO:0006355,GO:0006978,GO:0007141,GO:0007283,GO:0007420,GO:0008585,GO:0010165,GO:0010225,GO:0010332,GO:0010484,GO:0010485,GO:0030141,GO:0032465,GO:0032991,GO:0033593,GO:0033600,GO:0042771,GO:0042802,GO:0043015,GO:0045893,GO:0045931,GO:0051298,GO:0070200,GO:0071425,GO:0071479,GO:0090398,GO:1990391,GO:1990426,GO:2000001

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BRCA2 hsa:675 path:hsa03440 Homologous recombination - Homo sapiens (human)
BRCA2 hsa:675 path:hsa03460 Fanconi anemia pathway - Homo sapiens (human)
BRCA2 hsa:675 path:hsa05200 Pathways in cancer - Homo sapiens (human)
BRCA2 hsa:675 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
BRCA2 hsa:675 path:hsa05224 Breast cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BRCA1 BRCA2 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20081207 20173781 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 26192618 9488723 interaction type N/A ACSN
BRCA2 BARD1 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773 26192618 interaction type N/A ACSN
BRCA2 RAD51 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 26192618 9488723 interaction type N/A ACSN
BRCA2 RAD52 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773 26192618 interaction type N/A ACSN
BRCA2 XRCC2 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15590677 15650050 16697054 17349954 18660752 18931676 19473888 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20081207 20376879 20723763 20813759 21060331 21337561 22505525 22751496 22771115 23444773 26192618 interaction type N/A ACSN
BRCA2 XRCC3 10858305 10931916 11571269 11877377 12947387 15220350 15459660 15496928 15549137 15590677 15650050 15655342 16337602 16697054 17349954 18001825 18171670 18212739 18660752 18931676 19217833 19270065 19473888 19490890 19525936 19622404 19686080 19759212 19772495 19793801 19793861 19793862 19841479 19847258 20021983 20029420 20064462 20081207 20376879 20723763 20813759 21060331 21337561 22266823 22505525 22751496 22771115 23444773 26192618 interaction type N/A ACSN
FANCD2 BRCA2 10858305 10931916 11571269 11756412 11850621 11877377 11927554 12239151 12551922 12607003 12947387 14624239 14726013 15220350 15459660 15590677 15650050 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18660752 18809224 18931676 19075014 19217432 19264559 19473888 19525936 19622404 19686080 1974050 19759212 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20081207 20173781 20376879 20723763 20813759 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 26192618 9488723 interaction type N/A ACSN
BRCA2 FANCI 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337601 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18448394 18472307 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 19995904 20029420 20173781 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22505525 22743550 22751496 22771115 23414611 23444773 24050180 26192618 9488723 interaction type N/A ACSN
PCNA BRCA2 11756412 11850621 11877377 11927554 12239151 12551922 12607003 14624239 14726013 15459660 15703371 16337602 16697054 17303408 17349954 18082604 18082605 18085520 18087292 18584027 18809224 18931676 19075014 19217432 19264559 19622404 19686080 1974050 19772495 19793801 19793861 19793862 19841479 19847258 20029420 20723763 21060331 21337561 21376743 21574959 22021614 22101340 22743550 22751496 22771115 23414611 23444773 24050180 26192618 9488723 interaction type N/A ACSN
BRCA2 FANCC 15496928 15549137 15655342 16337602 16697054 18001825 18171670 18212739 18931676 19217833 19270065 19490890 19622404 19686080 19772495 19793861 19793862 19841479 19847258 20021983 20064462 22266823 26192618 interaction type N/A ACSN
BRCA2 FANCG 15496928 15549137 15655342 16337602 16697054 18001825 18171670 18212739 18931676 19217833 19270065 19490890 19622404 19686080 19772495 19793861 19793862 19841479 19847258 20021983 20064462 22266823 26192618 interaction type N/A ACSN
RPA1 BRCA2 26192618 association N/A ACSN
RPA2 BRCA2 26192618 association N/A ACSN
RPA3 BRCA2 26192618 association N/A ACSN
USP1 BRCA2 16531995 18082604 18082605 18931676 19075014 19217432 19264559 19622404 19686080 23589330 26192618 interaction type N/A ACSN
BRCC3 BRCA2 14636569 23180781 physical association anti tag coimmunoprecipitation InnateDB
BARD1 BRCA2 14636569 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
CCNA2 BRCA2 20005715 interaction type N/A PSP
CCNE1 BRCA2 20005715 interaction type N/A PSP
GRB2 BRCA2 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
PARP1 BRCA2 18990703 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
E2F4 BRCA2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 BRCA2 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC BRCA2 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NFKB1 BRCA2 10961992 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
YBX1 BRCA2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
RELA BRCA2 10961992 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
PRDM14 BRCA2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 BRCA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BRCA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BRCA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 BRCA2 11405179 trascriptional regulation,stimulation inferred by curator TFlink
CTBP1 BRCA2 18765668 trascriptional regulation,stimulation inferred by curator TFlink
ELF1 BRCA2 10557089 trascriptional regulation,stimulation inferred by curator TFlink
ESR2 BRCA2 18765668 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 BRCA2 18765668 trascriptional regulation,stimulation inferred by curator TFlink
HMG20B BRCA2 21399666 trascriptional regulation,stimulation inferred by curator TFlink
TP53 BRCA2 18765668 9619832 trascriptional regulation,stimulation inferred by curator TFlink
USF1 BRCA2 10557089 trascriptional regulation,stimulation inferred by curator TFlink
USF2 BRCA2 10557089 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000075D2F5 BRCA2 22158906 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00001EFBE3 BRCA2 18660546 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00001EFBE3 BRCA2 18660546 18927107 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000075D2F5 BRCA2 22158906 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00003380CC BRCA2 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 BRCA2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 BRCA2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000D5FFC BRCA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 BRCA2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA BRCA2 25416803 26750490 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PLK1 BRCA2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
RPA1 BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 RPA1 25361965 interaction type N/A PTMCode2
ATM BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 ATM 25361965 interaction type N/A PTMCode2
BRCA2 PLK1 25361965 interaction type N/A PTMCode2
BRCA1 BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 BRCA1 25361965 interaction type N/A PTMCode2
BARD1 BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 BARD1 25361965 interaction type N/A PTMCode2
KAT2B BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 KAT2B 25361965 interaction type N/A PTMCode2
STAT5A BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 STAT5A 25361965 interaction type N/A PTMCode2
KIF4A BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 KIF4A 25361965 interaction type N/A PTMCode2
TP53 BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 TP53 25361965 interaction type N/A PTMCode2
FANCE BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 FANCE 25361965 interaction type N/A PTMCode2
FANCD2 BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 FANCD2 25361965 interaction type N/A PTMCode2
SKP2 BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 SKP2 25361965 interaction type N/A PTMCode2
BCCIP BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 BCCIP 25361965 interaction type N/A PTMCode2
USP11 BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 USP11 25361965 interaction type N/A PTMCode2
PALB2 BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 PALB2 25361965 interaction type N/A PTMCode2
HMG20B BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 HMG20B 25361965 interaction type N/A PTMCode2
BRCA2 CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 BRCC3 25361965 interaction type N/A PTMCode2
BRCC3 BRCA2 25361965 interaction type N/A PTMCode2
BUB1B BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 BUB1B 25361965 interaction type N/A PTMCode2
FANCG BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 FANCG 25361965 interaction type N/A PTMCode2
MCPH1 BRCA2 25361965 interaction type N/A PTMCode2
BRCA2 MCPH1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MORF4L2 BRCA2 25348397 N/A physical interaction ComPPI
HNRNPC BRCA2 25348397 N/A physical interaction ComPPI
PCNA BRCA2 22293751 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TP53BP1 BRCA2 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
RAD21 BRCA2 22293751 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KEAP1 BRCA2 25348397 N/A physical interaction ComPPI
EGLN3 BRCA2 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
HSPB8 BRCA2 25348397 N/A physical interaction ComPPI
SP1 BRCA2 25348397 N/A physical interaction ComPPI
ATR BRCA2 25348397 N/A physical interaction ComPPI
GRB2 BRCA2 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
SMAD2 BRCA2 25348397 N/A physical interaction ComPPI
SMAD3 BRCA2 12165866 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
KAT2B BRCA2 14525934 25348397 9824164 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FLNA BRCA2 11602572 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
SERPINH1 BRCA2 25348397 N/A physical interaction ComPPI
RPA1 BRCA2 12527904 14525934 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
POLH BRCA2 24234451 24485656 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,fluorescence microscopy ComPPI,IntAct
PLK1 BRCA2 12815053 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
STAT5A BRCA2 12459499 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAPK6 BRCA2 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP2CA BRCA2 25348397 N/A physical interaction ComPPI
RAD51 BRCA2 10551859 11477095 12442171 12619154 14525934 15065660 15800615 15800651 17541404 18264088 19303847 19628690 20729832 20729859 21399666 21601571 22116401 22293751 24234451 25282148 25348397 9126738 9405383 9523196 9560268 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,classical fluorescence spectroscopy,two hybrid,coimmunoprecipitation,cross-linking study,electron microscopy,experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,comigration in non denaturing gel electrophoresis,competition binding,electron tomography,enzyme linked immunosorbent assay,electrophoretic mobility shift assay,in vitro,in vivo,confocal microscopy,scanning electron microscopy,two hybrid ComPPI,HPRD,IntAct
FANCD2 BRCA2 14525934 15115758 18212739 24234451 25348397 association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
BRCA2 BUB1B 10749118 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
BRCA2 HMG20B 11207365 12032298 14525934 21399666 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
BRCA2 EMSY 14525934 14651845 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BRCA2 BCCIP 11313963 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
BRCA2 BRCA1 11477095 14525934 19369211 22193777 24234451 25348397 29656893 9774970 colocalization,association,physical association anti bait coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,molecular sieving,physical interaction,in vitro,in vivo,tandem affinity purification,proximity-dependent biotin identification ComPPI,HPRD,IntAct
BRCA2 PALB2 14525934 16793542 17420451 19369211 19609323 22193777 22293751 24141787 24234451 24485656 25348397 26649820 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,fluorescence technology,pull down,x-ray crystallography,physical interaction,fluorescence microscopy,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
BRCA2 CFAP52 14525934 15967112 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BRCA2 CCNA2 14525934 15800651 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BRCA2 CCNE1 14525934 15800651 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BRCA2 CDK2 14525934 15800615 15800651 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BRCA2 FANCE 14525934 15199141 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BRCA2 FANCG 12915460 14525934 16621732 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
BRCA2 SEM1 25348397 N/A physical interaction ComPPI
BRCA2 BARD1 25348397 N/A physical interaction ComPPI
BRCA2 BABAM2 25348397 N/A physical interaction ComPPI
BRCA2 BRCC3 25348397 N/A physical interaction ComPPI
BRCA2 TP53 14525934 14636569 20421506 24234451 25348397 27898060 9811893 N/A classical fluorescence spectroscopy,coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,nuclear magnetic resonance,pull down,physical interaction ComPPI,HPRD,IntAct,OmniPath
BRCA2 ATM 25348397 N/A physical interaction ComPPI
BRCA2 CHEK2 25348397 N/A physical interaction ComPPI
BRCA2 AURKB 25348397 N/A physical interaction ComPPI
BRCA2 PMS2 25348397 N/A physical interaction ComPPI
BRCA2 PMS2CL 25348397 N/A physical interaction ComPPI
BRCA2 PMS1 25348397 N/A physical interaction ComPPI
BRCA2 MCPH1 25348397 N/A physical interaction ComPPI
BRCA2 UQCC1 25348397 N/A physical interaction ComPPI
BRCA2 USP11 15314155 24234451 25348397 26649820 27898060 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
BRCA2 KIF4A 25348397 N/A physical interaction ComPPI
BRCA2 H2AX 25348397 N/A physical interaction ComPPI
BRCA2 XRCC3 24141787 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BRCA2 BACH1 25348397 N/A physical interaction ComPPI
BRCA2 MORF4L1 25348397 N/A physical interaction ComPPI
BRCA2 MGMT 25348397 N/A physical interaction ComPPI
BRCA2 PSMD3 25348397 N/A physical interaction ComPPI
BRCA2 PSMD6 25348397 N/A physical interaction ComPPI
BRCA2 MAGED1 25348397 N/A physical interaction ComPPI
BRCA2 NEDD4 25348397 N/A physical interaction ComPPI
BRCA2 RAD23A 16712842 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
BRCA2 DMC1 17541404 20729832 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,filter binding,peptide array,pull down,physical interaction,competition binding ComPPI,IntAct
BRCA2 MLF1 25348397 N/A physical interaction ComPPI
BRCA2 NSL1 25348397 N/A physical interaction ComPPI
BRCA2 NSMCE4A 25348397 N/A physical interaction ComPPI
BRCA2 SDF4 25348397 N/A physical interaction ComPPI
BRCA2 DTNBP1 25348397 N/A physical interaction ComPPI
BRCA2 DSN1 25348397 N/A physical interaction ComPPI
BRCA2 CARD8 25348397 N/A physical interaction ComPPI
BRCA2 VPS28 25348397 N/A physical interaction ComPPI
BRCA2 MIER2 25348397 N/A physical interaction ComPPI
BRCA2 RABL2A 25348397 N/A physical interaction ComPPI
BRCA2 IER2 25348397 N/A physical interaction ComPPI
BRCA2 PDS5B 22293751 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
BRCA2 CDC45 22293751 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BRCA2 SMC3 22293751 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BRCA2 ERCC5 25348397 N/A physical interaction ComPPI
BRCA2 BIVM 25348397 N/A physical interaction ComPPI
BRCA2 C6ORF141 25348397 N/A physical interaction ComPPI
BRCA2 TEX45 25348397 N/A physical interaction ComPPI
BRCA2 NCAPH2 25348397 N/A physical interaction ComPPI
BRCA2 PPM1E 25348397 N/A physical interaction ComPPI
BRCA2 RFXANK 25348397 N/A physical interaction ComPPI
BRCA2 L3MBTL1 25348397 N/A physical interaction ComPPI
BRCA2 BAG4 25348397 N/A physical interaction ComPPI
BRCA2 SNX32 25348397 N/A physical interaction ComPPI
BRCA2 CNKSR1 25348397 N/A physical interaction ComPPI
BRCA2 AARSD1 25348397 N/A physical interaction ComPPI
BRCA2 RAD51C 24141787 24234451 25348397 association anti tag coimmunoprecipitation,pull down,physical interaction,immunodepleted coimmunoprecipitation ComPPI,IntAct
BRCA2 FANCI 25348397 N/A physical interaction ComPPI
BRCA2 RNF168 25348397 N/A physical interaction ComPPI
BRCA2 USP21 25348397 N/A physical interaction ComPPI
BRCA2 FBXL13 25348397 N/A physical interaction ComPPI
BRCA2 XPO1 24013206 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
BRCA2 RPA2 12527904 24234451 25348397 association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
BRCA2 ABL1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
BRCA2 FYN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
BRCA2 MTA2 19703393 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
BRCA2 SYCP3 22116401 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,fluorescence microscopy ComPPI,IntAct
BRCA2 KATNAL2 24234451 25348397 26929214 association tandem affinity purification ComPPI,IntAct
BRCA2 MDC1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
SEM1 BRCA2 10373512 12228710 14525934 16205630 22293751 24013206 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,fluorescent resonance energy transfer,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
SPANXA1 BRCA2 25348397 N/A physical interaction ComPPI
DRL BRCA2 25348397 N/A two hybrid ComPPI
BRCA2 CDK1 14525934 15800651 N/A experimental interaction detection HPRD
BRCA2 BRCA2 21601571 24234451 25282148 physical association competition binding,electron tomography IntAct
BRCA2 RAD51 22293751 24234451 association anti tag coimmunoprecipitation IntAct
BRCA2 PDS5B 22293751 24234451 association anti tag coimmunoprecipitation IntAct
BRCA2 FANCD2 22293751 24234451 association anti tag coimmunoprecipitation IntAct
BRCA2 PARP1 18990703 24234451 association,physical association pull down,chromatin immunoprecipitation assay,electrophoretic mobility supershift assay IntAct
ZC3H18 BRCA2 24234451 29298432 association chromatin immunoprecipitation assay IntAct
NCL BRCA2 24234451 30021884 physical association cross-linking study IntAct
PLK1 BRCA2 12815053 14647413 24448238 27898060 inhibition N/A OmniPath
CHEK1 BRCA2 18317453 27898060 stimulant N/A OmniPath
BRCA2 POLH 24485656 27898060 stimulant N/A OmniPath
CHEK2 BRCA2 14623252 17525332 18317453 27898060 N/A N/A OmniPath
MCPH1 BRCA2 19549900 20107607 27898060 stimulant N/A OmniPath
CDK2 BRCA2 15800615 15800651 27898060 N/A N/A OmniPath
SEM1 BRCA2 10373512 12228710 16205630 16239144 17145710 17563742 22293751 26145171 27898060 stimulant N/A OmniPath
CDK1 BRCA2 15800615 15800651 27898060 N/A N/A OmniPath
PALB2 BRCA2 15115758 16793542 17200668 17200672 17488615 19268590 19369211 19553677 19584259 19609323 20332121 22193777 22293751 23038782 23585894 24141787 24485656 26649820 27898060 stimulant N/A OmniPath

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