Gene Information gene info

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GENE：EXOSC3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EXOSC3
FullNmae exosome component 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17944
EnsembleID ENSG00000107371
Uniprot Q9NQT5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EXOSC3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EXOSC3 GO:0000175,GO:0000176,GO:0000176,GO:0000176,GO:0000177,GO:0000177,GO:0000177,GO:0000178,GO:0000178,GO:0000467,GO:0000791,GO:0003723,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005829,GO:0006364,GO:0006396,GO:0006401,GO:0034427,GO:0034475,GO:0043928,GO:0043928,GO:0045006,GO:0045190,GO:0045830,GO:0071034,GO:0071034,GO:0071035,GO:0071038,GO:0071051,GO:0101019

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EXOSC3 hsa:51010 path:hsa03018 RNA degradation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 EXOSC3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 EXOSC3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 EXOSC3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 EXOSC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EXOSC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EXOSC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 EXOSC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 EXOSC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EXOSC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EXOSC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 EXOSC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
EXOSC5 EXOSC3 11110791 12419256 12837249 14525934 15231747 17942686 20531389 21255825 22939629 24234451 24336220 25348397 26186194 26344197 26496610 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
GABARAPL2 EXOSC3 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EXOSC1 EXOSC3 20531389 21255825 24234451 25043052 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,molecular sieving,physical interaction ComPPI,IntAct
DDX17 EXOSC3 18334637 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC8 EXOSC3 15231747 20531389 21255825 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
JUN EXOSC3 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
HNRNPL EXOSC3 25348397 N/A physical interaction ComPPI
EXOSC10 EXOSC3 20531386 20531389 21255825 24234451 25348397 colocalization,association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cosedimentation,physical interaction ComPPI,IntAct
EGFR EXOSC3 25348397 N/A physical interaction ComPPI
MTREX EXOSC3 25348397 N/A physical interaction ComPPI
EXOSC6 EXOSC3 20531389 21255825 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AICDA EXOSC3 21255825 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC4 EXOSC3 14525934 15231747 20531386 20531389 21255825 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
FOXA1 EXOSC3 25348397 N/A physical interaction ComPPI
TRIM25 EXOSC3 25348397 N/A physical interaction ComPPI
EXOSC2 EXOSC3 11719186 16396833 17545563 20531389 21255825 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cosedimentation through density gradient,physical interaction,tandem affinity purification ComPPI,IntAct
EXOSC9 EXOSC3 20531389 24234451 25348397 26496610 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
EXOSC7 EXOSC3 20531389 21255825 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KHSRP EXOSC3 14525934 15175153 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CDK5RAP1 EXOSC3 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
IFI16 EXOSC3 25348397 N/A physical interaction ComPPI
RRP1B EXOSC3 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EXOSC3 HDGF 21907836 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
EXOSC3 APP 25348397 N/A physical interaction ComPPI
EXOSC3 ATP5F1D 25348397 N/A physical interaction ComPPI
EXOSC3 NXF1 25348397 N/A physical interaction ComPPI
EXOSC3 HBS1L 25348397 N/A physical interaction ComPPI
EXOSC3 ZCCHC8 25348397 N/A physical interaction ComPPI
EXOSC3 CERT1 25348397 N/A physical interaction ComPPI
EXOSC3 FBL 25348397 N/A physical interaction ComPPI
EXOSC3 ZC3HAV1 21876179 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct

Source Target Pmid Interactiontype Methods Database
URS00008B3089 EXOSC3 27087310 direct interaction,inhibition N/A NPInter

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