GENE：FAM117B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | FAM117B |
| FullNmae | family with sequence similarity 117 member B |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:14440 |
| EnsembleID | ENSG00000138439 |
| Uniprot | Q6P1L5 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| FAM117B | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| FAM117B | GO:0005515 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | FAM117B | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | FAM117B | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | FAM117B | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | FAM117B | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | FAM117B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | FAM117B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | FAM117B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | FAM117B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | FAM117B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | FAM117B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | FAM117B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003380CC | FAM117B | 19296470 | rna interference,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00003380CC | FAM117B | 19296470 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000021D7C8 | FAM117B | 23622248 23824327 25416803 27418678 | mrna cleavage,inhibition | clip,clash | TarBase |
| URS00002075FA | FAM117B | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | FAM117B | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | FAM117B | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | FAM117B | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | FAM117B | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | FAM117B | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000009C45F | FAM117B | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CF056 | FAM117B | 23824327 24906430 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000411752 | FAM117B | 24906430 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065FDF | FAM117B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005F305A | FAM117B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005D986D | FAM117B | 23824327 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000508C13 | FAM117B | 23824327 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000045DBD | FAM117B | 23824327 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000004CA3 | FAM117B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003CF1AD | FAM117B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CF3F0 | FAM117B | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000046CDA6 | FAM117B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000013ABA3 | FAM117B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000486E0B | FAM117B | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000007FBA | FAM117B | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000021202F | FAM117B | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CCD18 | FAM117B | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075CC78 | FAM117B | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D814 | FAM117B | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00001012BC | FAM117B | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AD2AA | FAM117B | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DYNLL1 | FAM117B | 24234451 25348397 26496610 27173435 | association,physical association | anti tag coimmunoprecipitation,physical interaction,two hybrid array,tandem affinity purification,two hybrid prey pooling approach,inference by socio-affinity scoring | ComPPI,IntAct |
| PSMC3 | FAM117B | 25348397 | N/A | physical interaction | ComPPI |
| KEAP1 | FAM117B | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| PNMA2 | FAM117B | 25348397 | N/A | physical interaction | ComPPI |
| TSC22D3 | FAM117B | 25348397 | N/A | physical interaction | ComPPI |
| MYC | FAM117B | 21150319 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| HNRNPL | FAM117B | 25348397 | N/A | physical interaction | ComPPI |
| DYRK1B | FAM117B | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| SFN | FAM117B | 15778465 24234451 25348397 | physical association | tandem affinity purification | ComPPI,IntAct |
| BANP | FAM117B | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| ELAVL1 | FAM117B | 25348397 | N/A | physical interaction | ComPPI |
| FNTA | FAM117B | 25348397 | N/A | physical interaction | ComPPI |
| TNKS | FAM117B | 25348397 | N/A | physical interaction | ComPPI |
| NRBP1 | FAM117B | 25348397 | N/A | physical interaction | ComPPI |
| TNKS2 | FAM117B | 25348397 | N/A | physical interaction | ComPPI |
| STAT3 | FAM117B | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array,validated two hybrid | ComPPI,IntAct |
| DCAF7 | FAM117B | 24234451 25348397 27173435 | association,physical association | physical interaction,tandem affinity purification,inference by socio-affinity scoring | ComPPI,IntAct |
| DYRK1A | FAM117B | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| SHMT2 | FAM117B | 25348397 | N/A | physical interaction | ComPPI |
| NEDD1 | FAM117B | 25348397 | N/A | physical interaction | ComPPI |
| GAPDHS | FAM117B | 25348397 | N/A | physical interaction | ComPPI |