GENE：CXCL12
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CXCL12 |
| FullNmae | C-X-C motif chemokine ligand 12 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10672 |
| EnsembleID | ENSG00000107562 |
| Uniprot | P48061 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CXCL12 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CXCL12 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CXCL12 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CXCL12 | GO:0001666,GO:0001764,GO:0001938,GO:0005102,GO:0005178,GO:0005515,GO:0005576,GO:0006874,GO:0006935,GO:0006952,GO:0006955,GO:0007155,GO:0007165,GO:0007186,GO:0007411,GO:0008009,GO:0008009,GO:0008009,GO:0008009,GO:0008015,GO:0008064,GO:0008083,GO:0008344,GO:0009615,GO:0009897,GO:0022029,GO:0030335,GO:0031100,GO:0033603,GO:0033622,GO:0038146,GO:0042379,GO:0043434,GO:0045236,GO:0045236,GO:0045666,GO:0045785,GO:0048842,GO:0050930,GO:0050965,GO:0050966,GO:0060326,GO:0060326,GO:0062023,GO:0070062,GO:0070098,GO:0070098,GO:0090026,GO:0090280,GO:1902230,GO:1903237,GO:1990478,GO:1990869,GO:2000406,GO:2000669 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CXCL12 | hsa:6387 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| CXCL12 | hsa:6387 | path:hsa04061 | Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human) |
| CXCL12 | hsa:6387 | path:hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| CXCL12 | hsa:6387 | path:hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| CXCL12 | hsa:6387 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
| CXCL12 | hsa:6387 | path:hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| CXCL12 | hsa:6387 | path:hsa04672 | Intestinal immune network for IgA production - Homo sapiens (human) |
| CXCL12 | hsa:6387 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| CXCL12 | hsa:6387 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| CXCL12 | hsa:6387 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| CXCL12 | hsa:6387 | path:hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CXCL12 | CXCR4 | 15261139 15882617 17035340 20535745 20644254 21521526 22025564 23034983 23402812 23567181 24277834 26192618 | association | N/A | ACSN |
| HGF | CXCL12 | 12649206 15059978 16212809 17145802 18633355 19631971 22763439 23402812 23667593 26192618 26366398 26819959 27474009 28475121 9242465 | interaction type | N/A | ACSN |
| JUND | CXCL12 | 20535745 26192618 | interaction type | N/A | ACSN |
| HIF1A | CXCL12 | 10804084 16110315 16127144 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824 26192618 | interaction type | N/A | ACSN |
| HSF1 | CXCL12 | 25083868 26192618 | interaction type | N/A | ACSN |
| CXCL12 | RHOA | 15261139 15882617 17035340 20535745 20644254 21521526 22025564 23034983 23402812 23567181 24277834 26192618 | interaction type | N/A | ACSN |
| VCAN | CXCL12 | 11083865 23180781 | physical association | solid phase assay | InnateDB |
| CXCR4 | CXCL12 | 16725153 19837984 23180781 | physical association | nuclear magnetic resonance,pull down | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | CXCL12 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CXCL12 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYB | CXCL12 | 20043041 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CEBPA | CXCL12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CXCL12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CXCL12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CXCL12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | CXCL12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CXCL12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | CXCL12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | CXCL12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | CXCL12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ESR1 | CXCL12 | 18563714 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXF2 | CXCL12 | 19562724 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | CXCL12 | 12384916 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | CXCL12 | 17530707 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | CXCL12 | 17530707 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SNAI2 | CXCL12 | 22074556 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00001D69F6 | CXCL12 | 23396050 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS00000821E0 | CXCL12 | \N | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS00001CC864 | CXCL12 | N/A 14697198 | rna interference,inhibition | experimental interaction detection,miRNA interference luciferase reporter assay | miRSponge |
| URS0000001EB3 | CXCL12 | 19524507 | rna interference,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00001CC864 | CXCL12 | 14697198 25416803 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,miRNA interference luciferase reporter assay | TarBase |
| URS0000001EB3 | CXCL12 | 19524507 24855107 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00001D69F6 | CXCL12 | 23396050 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS00001EFBE3 | CXCL12 | 23963696 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000100748 | CXCL12 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000085F64 | CXCL12 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | CXCL12 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000170CF4 | CXCL12 | 25416803 28236026 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS000031602A | CXCL12 | 25416803 26976451 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00001E3523 | CXCL12 | 25416803 26847706 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CXCL9 | CXCL12 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CTSG | CXCL12 | 11241273 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| CD4 | CXCL12 | 10600606 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| ELANE | CXCL12 | 12068293 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| PF4 | CXCL12 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,physical interaction,surface plasmon resonance array | ComPPI,IntAct |
| CCL5 | CXCL12 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CCR4 | CXCL12 | 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI |
| CCL13 | CXCL12 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| DPP4 | CXCL12 | 11390394 14525934 21314817 24234451 25348397 | cleavage reaction | experimental interaction detection,enzymatic study,protease assay,in vitro | ComPPI,HPRD,IntAct |
| CXCL12 | MMP2 | 11571304 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| CXCL12 | CXCR4 | 10233851 14525934 25348397 8752281 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| CXCL12 | FN1 | 11023498 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| CXCL12 | VCAN | 25348397 | N/A | physical interaction | ComPPI |
| CXCL12 | DAZAP2 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| CXCL12 | CCR10 | 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI |
| CXCL12 | DPP8 | 25348397 | N/A | enzymatic study | ComPPI |
| CXCL12 | CCL11 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL12 | CCL21 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL12 | CCL25 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL12 | CXCL17 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL12 | CCL20 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL12 | CXCL10 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL12 | CXCL6 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL12 | PF4V1 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL12 | CXCL2 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL12 | XCL1 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL12 | CCL28 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL12 | CCL26 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL12 | PPBP | 24234451 25348397 28381538 | N/A | filter binding | ComPPI,IntAct |
| CXCL11 | CXCL12 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| XCL2 | CXCL12 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL14 | CXCL12 | 24234451 25348397 28381538 | N/A | filter binding,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| CXCL12 | CXCL12 | 10954912 14525934 24234451 28381538 9618518 | N/A | experimental interaction detection,surface plasmon resonance | HPRD,IntAct |
| CXCL12 | CXCR4 | 10233851 11859124 16725153 19837984 24218476 27898060 8752280 8752281 9551924 9712844 | stimulant | N/A | OmniPath |
| CXCR4 | CXCL12 | 10233851 16725153 19837984 27898060 8752281 | N/A | N/A | OmniPath |
| CXCL12 | ITGB1 | 18448868 27898060 | N/A | N/A | OmniPath |
| ESR1 | CXCL12 | 16912174 27898060 | stimulant | N/A | OmniPath |
| CXCL12 | CXCR3 | 27898060 9660793 | stimulant | N/A | OmniPath |
| VCAN | CXCL12 | 11083865 27898060 | N/A | N/A | OmniPath |
| CXCL12 | VCAN | 11083865 27898060 | N/A | N/A | OmniPath |
| CXCL12 | DPP4 | 11390394 21314817 24218476 27898060 | N/A | N/A | OmniPath |
| CTSG | CXCL12 | 11241273 27898060 | N/A | N/A | OmniPath |
| CXCL12 | ACKR3 | 16107333 20956518 23396314 27898060 | stimulant | N/A | OmniPath |