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GENE：GRIN2D

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GRIN2D
FullNmae glutamate ionotropic receptor NMDA type subunit 2D
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4588
EnsembleID ENSG00000105464
Uniprot O15399

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GRIN2D immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GRIN2D GO:0001964,GO:0004970,GO:0004972,GO:0004972,GO:0004972,GO:0004972,GO:0005515,GO:0005789,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0007420,GO:0008344,GO:0016595,GO:0017146,GO:0017146,GO:0017146,GO:0017146,GO:0019722,GO:0022843,GO:0022849,GO:0035235,GO:0035249,GO:0042165,GO:0045211,GO:0048167,GO:0048168,GO:0048787,GO:0051930,GO:0051968,GO:0060079,GO:0060291,GO:0097553,GO:0098655,GO:0098686,GO:0098839,GO:0098976,GO:0098978,GO:0099505,GO:0099507,GO:1904062,GO:1904315,GO:2000463

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GRIN2D hsa:2906 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
GRIN2D hsa:2906 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
GRIN2D hsa:2906 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
GRIN2D hsa:2906 path:hsa04713 Circadian entrainment - Homo sapiens (human)
GRIN2D hsa:2906 path:hsa04720 Long-term potentiation - Homo sapiens (human)
GRIN2D hsa:2906 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
GRIN2D hsa:2906 path:hsa05010 Alzheimer disease - Homo sapiens (human)
GRIN2D hsa:2906 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
GRIN2D hsa:2906 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
GRIN2D hsa:2906 path:hsa05020 Prion disease - Homo sapiens (human)
GRIN2D hsa:2906 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
GRIN2D hsa:2906 path:hsa05030 Cocaine addiction - Homo sapiens (human)
GRIN2D hsa:2906 path:hsa05031 Amphetamine addiction - Homo sapiens (human)
GRIN2D hsa:2906 path:hsa05033 Nicotine addiction - Homo sapiens (human)
GRIN2D hsa:2906 path:hsa05034 Alcoholism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CRK GRIN2D 20005715 interaction type N/A PSP,SignaLink
DLG4 GRIN2D 20005715 interaction type N/A PSP
PATJ GRIN2D 20005715 interaction type N/A PSP
PPP2R1A GRIN2D 20005715 interaction type N/A PSP
TRAF3 GRIN2D 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR GRIN2D 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 GRIN2D 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 GRIN2D 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 GRIN2D 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 GRIN2D 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 GRIN2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GRIN2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GRIN2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GRIN2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GRIN2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GRIN2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 GRIN2D N/A trascriptional regulation,stimulation inferred by curator TFlink
ESR2 GRIN2D N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 GRIN2D 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00005ACA7C GRIN2D 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B989F GRIN2D 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000235862 GRIN2D 20371350 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
VCP GRIN2D 25348397 N/A physical interaction ComPPI
CRK GRIN2D 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
DLG4 GRIN2D 11937501 14525934 24234451 25348397 7569905 N/A two hybrid,experimental interaction detection,enzyme linked immunosorbent assay,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
HRAS GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKCE GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CIT GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
DLG2 GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
DNM1 GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HSPA1A GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HSPA1B GRIN2D 25348397 N/A in vivo ComPPI
TRAF3 GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKCB GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HNRNPU GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAP2 GRIN2D 25348397 N/A in vivo ComPPI
RPS6KA3 GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAP2K2 GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
DUSP4 GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SPTAN1 GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRIN2D PRKCG 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRIN2D RAP2A 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRIN2D CDH2 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRIN2D IL16 25348397 N/A two hybrid,in vitro ComPPI
GRIN2D PATJ 25348397 N/A two hybrid,in vitro,in vivo ComPPI
GRIN2D INA 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRIN2D PPP2R2A 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRIN2D GRIN1 12191494 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRIN2D SYNGAP1 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRIN2D NANOS1 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRIN2D DLGAP4 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRIN2D CTNNB1 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRIN2D CLTC 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRIN2D FUS 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GRIN2D NF1 25348397 N/A in vivo ComPPI
GRIN2D NEDD4 25348397 N/A physical interaction ComPPI
GRIN2D ABL1 10777567 14525934 N/A experimental interaction detection HPRD
GRIN2D TJP1 10862698 14525934 N/A experimental interaction detection HPRD
PPP2R1A GRIN2D 10862698 14525934 N/A experimental interaction detection HPRD
GRIN2D DLG1 24234451 30126976 N/A p8 filamentous phage display IntAct

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