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GENE：EPHA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EPHA2
FullNmae EPH receptor A2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3386
EnsembleID ENSG00000142627
Uniprot P29317

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EPHA2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EPHA2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EPHA2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EPHA2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
EPHA2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
EPHA2 GO:0001501,GO:0001570,GO:0001618,GO:0001649,GO:0002043,GO:0004714,GO:0004714,GO:0005003,GO:0005515,GO:0005524,GO:0005886,GO:0005886,GO:0005925,GO:0005925,GO:0006954,GO:0007155,GO:0007169,GO:0007275,GO:0008630,GO:0009986,GO:0009986,GO:0010591,GO:0014028,GO:0016310,GO:0016477,GO:0016525,GO:0019838,GO:0021915,GO:0030027,GO:0030182,GO:0030216,GO:0030316,GO:0030335,GO:0031256,GO:0031258,GO:0032587,GO:0032682,GO:0033598,GO:0033628,GO:0033674,GO:0036342,GO:0043235,GO:0043491,GO:0043535,GO:0045296,GO:0045765,GO:0046058,GO:0046718,GO:0046849,GO:0048013,GO:0048320,GO:0048870,GO:0050830,GO:0051898,GO:0060035,GO:0060326,GO:0060444,GO:0070160,GO:0070309,GO:0070372,GO:0070848,GO:0072659,GO:0090630,GO:0140677,GO:1901491,GO:1903078,GO:1903348,GO:1904238

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EPHA2 hsa:1969 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
EPHA2 hsa:1969 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
EPHA2 hsa:1969 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
EPHA2 hsa:1969 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
EPHA2 hsa:1969 path:hsa04360 Axon guidance - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EFNA2 EPHA2 18988627 23331499 8755474 9267020 stimulation N/A SignaLink,SignaLink
EFNA1 EPHA2 14692877 18988627 23331499 7973638 8755474 9576626 stimulation N/A SignaLink,SignaLink
EPHA2 PIK3R2 23331499 7982920 stimulation N/A SignaLink
EPHA2 GRAP 12400011 23331499 stimulation N/A SignaLink
ACP1 EPHA2 12167657 23331499 stimulation N/A SignaLink
EPHA2 SHC1 12400011 23331499 stimulation N/A SignaLink
EFNA4 EPHA2 23331499 9576626 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GRB2 EPHA2 12400011 20005715 21071413 interaction type N/A PSP,SignaLink
PIK3R1 EPHA2 20005715 interaction type N/A PSP,SignaLink
SHC1 EPHA2 12400011 18988627 20005715 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
AR EPHA2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 EPHA2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 EPHA2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 EPHA2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 EPHA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EPHA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 EPHA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EPHA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 EPHA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS EPHA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EPHA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 EPHA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 EPHA2 11641774 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 EPHA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIC1 EPHA2 22184117 trascriptional regulation,stimulation inferred by curator TFlink
MTA1 EPHA2 22184117 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 EPHA2 21264258 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000003ABC4 EPHA2 21264258 25416803 26191168 26843134 27746866 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000AA464 EPHA2 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 EPHA2 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000041FA2C EPHA2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000486E0B EPHA2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00006DE17B EPHA2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000047A67D EPHA2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000036B845 EPHA2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A9FB9 EPHA2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000D0BB4 EPHA2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075ABF4 EPHA2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000044FD7 EPHA2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 EPHA2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000021D7C8 EPHA2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000027080C EPHA2 22012620 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000041E949 EPHA2 22012620 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000346991 EPHA2 22012620 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000009265 EPHA2 22012620 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000058863C EPHA2 22012620 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000008DA94 EPHA2 22012620 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000003E1A9 EPHA2 22012620 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003CC709 EPHA2 22012620 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E5E03 EPHA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000024A59E EPHA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002EF20A EPHA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004C6C6F EPHA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D15B EPHA2 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
EPHA2 EPHA2 22135298 phosphorylation N/A PhosphoSite
EPHA2 CLDN4 22135298 phosphorylation N/A PhosphoSite
RPS6KA1 EPHA2 22135298 phosphorylation N/A PhosphoSite
AKT1 EPHA2 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 EPHA2 22135298 phosphorylation N/A PhosphoSite
TIAM1 EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 TIAM1 25361965 interaction type N/A PTMCode2
TNFAIP1 EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 TNFAIP1 25361965 interaction type N/A PTMCode2
EFNA5 EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 EFNA5 25361965 interaction type N/A PTMCode2
CBL EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 CBL 25361965 interaction type N/A PTMCode2
ACP1 EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 ACP1 25361965 interaction type N/A PTMCode2
GRB2 EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 GRB2 25361965 interaction type N/A PTMCode2
EPHA2 EFNA1 25361965 interaction type N/A PTMCode2
EFNA1 EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 EFNA3 25361965 interaction type N/A PTMCode2
EFNA3 EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 SLA 25361965 interaction type N/A PTMCode2
SLA EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 SHC1 25361965 interaction type N/A PTMCode2
SHC1 EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 EFNA4 25361965 interaction type N/A PTMCode2
EFNA4 EPHA2 25361965 interaction type N/A PTMCode2
CDH5 EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 CDH5 25361965 interaction type N/A PTMCode2
PIK3R1 EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 PIK3R1 25361965 interaction type N/A PTMCode2
CTNNB1 EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 CTNNB1 25361965 interaction type N/A PTMCode2
EFNA2 EPHA2 25361965 interaction type N/A PTMCode2
EPHA2 EFNA2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIK3R2 EPHA2 14525934 25348397 7982920 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
VPS4B EPHA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA3 EPHA2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ZBTB14 EPHA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ITGB5 EPHA2 25348397 N/A physical interaction ComPPI
HSP90AB1 EPHA2 22939624 24234451 25348397 physical association anti tag coimmunoprecipitation,luminescence based mammalian interactome mapping ComPPI,IntAct
LSM7 EPHA2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RD3 EPHA2 25348397 N/A physical interaction ComPPI
CBL EPHA2 12496371 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SLA EPHA2 14525934 25348397 7543898 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
TIAM1 EPHA2 14525934 14988728 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PIK3R1 EPHA2 25348397 N/A physical interaction ComPPI
PTPN11 EPHA2 10655584 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SHC1 EPHA2 12400011 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GRB2 EPHA2 12400011 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
INPPL1 EPHA2 25348397 N/A isothermal titration calorimetry,nuclear magnetic resonance,physical interaction ComPPI
ITGA3 EPHA2 25348397 N/A physical interaction ComPPI
ITGB1 EPHA2 25348397 N/A physical interaction ComPPI
ITGAV EPHA2 25348397 N/A physical interaction ComPPI
HSP90AA1 EPHA2 25348397 N/A physical interaction ComPPI
NTRK1 EPHA2 25348397 N/A physical interaction ComPPI
CDH1 EPHA2 25348397 N/A physical interaction ComPPI
CDH5 EPHA2 14525934 16481735 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ITGB3 EPHA2 25348397 N/A physical interaction ComPPI
OPCML EPHA2 25348397 N/A physical interaction ComPPI
EPHA2 TNFAIP1 14525934 25348397 7536959 N/A experimental interaction detection,in vivo ComPPI,HPRD
EPHA2 EFNA1 14525934 14692877 19525919 19573808 20505120 22244754 24234451 25348397 7973638 8755474 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
EPHA2 EFNA4 10607706 14525934 25348397 8755474 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EPHA2 EFNA3 12907451 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EPHA2 EFNA5 14525934 20228801 20505120 24234451 25348397 9245480 physical association experimental interaction detection,light scattering,molecular sieving,pull down,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
EPHA2 EFNA2 14525934 25348397 8755474 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EPHA2 RASA1 14525934 16051609 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EPHA2 EGFR 14525934 15657067 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
EPHA2 CLDN4 14525934 16236711 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EPHA2 PTK2 10655584 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
EPHA2 ACP1 12167657 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
EPHA2 ELAVL1 25348397 N/A physical interaction ComPPI
EPHA2 APP 25348397 N/A physical interaction ComPPI
EPHA2 EEF2 25348397 N/A physical interaction ComPPI
EPHA2 HSP90AA2P 25348397 N/A physical interaction ComPPI
EPHA2 GATAD1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EPHA2 RBL1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EPHA2 NUDT9 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EPHA2 GRK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EPHA2 CDK17 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EPHA2 PSME2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EPHA2 CLTC 25348397 N/A physical interaction ComPPI
EPHA2 AP2M1 25348397 N/A physical interaction ComPPI
EPHA2 AP2B1 25348397 N/A physical interaction ComPPI
EPHA2 AP2A1 25348397 N/A physical interaction ComPPI
EPHA2 AP2S1 25348397 N/A physical interaction ComPPI
EPHA2 EPS15 25348397 N/A physical interaction ComPPI
EPHA2 UBE4A 25348397 N/A physical interaction ComPPI
EPHA2 SLC25A41 25348397 N/A physical interaction ComPPI
EPHA2 TAS2R7 25348397 N/A physical interaction ComPPI
EPHA2 CCR1 25348397 N/A physical interaction ComPPI
EPHA2 TMEM185A 25348397 N/A physical interaction ComPPI
EPHA2 PIFO 25348397 N/A physical interaction ComPPI
EPHA2 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
EPHA2 TMEM216 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
EPHA2 FANCD2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
EPHA2 SSR3 25348397 N/A physical interaction ComPPI
EPHA2 TGFBR1 25348397 N/A physical interaction ComPPI
EPHA2 SCAMP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EPHA2 HEXIM1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EPHA2 GOLIM4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EPHA2 NDUFA13 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EPHA2 SMARCAD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EPHA2 MRPS35 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EPHA2 MICALL1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EPHA2 TSG101 25348397 N/A physical interaction ComPPI
EPHA2 DUSP18 25348397 N/A physical interaction ComPPI
EPHA2 DUSP19 25348397 N/A physical interaction ComPPI
EPHA2 DUSP29 25348397 N/A physical interaction ComPPI
EPHA2 DUSP26 25348397 N/A physical interaction ComPPI
EPHA2 SDC1 25348397 N/A physical interaction ComPPI
EPHA2 CYP2S1 25348397 N/A physical interaction ComPPI
EPHA2 GJB7 25348397 N/A physical interaction ComPPI
EPHA2 LRRIQ1 25348397 N/A physical interaction ComPPI
EPHA2 NCSTN 25348397 N/A physical interaction ComPPI
EPHA2 NTRK3 25348397 N/A physical interaction ComPPI
EPHA2 MAS1 25348397 N/A physical interaction ComPPI
EPHA2 CIR1 25348397 N/A physical interaction ComPPI
EPHA2 SIGLECL1 25348397 N/A physical interaction ComPPI
EPHA2 TARDBP 25348397 N/A physical interaction ComPPI
EPHA2 MRAP2 25348397 N/A physical interaction ComPPI
EPHA2 PPM1L 25348397 N/A physical interaction ComPPI
EPHA2 ILKAP 25348397 N/A physical interaction ComPPI
EPHA2 PTPRR 25348397 N/A physical interaction ComPPI
EPHA2 PTPN7 25348397 N/A physical interaction ComPPI
EPHA2 STYX 25348397 N/A physical interaction ComPPI
EPHA2 TPTE 25348397 N/A physical interaction ComPPI
EPHA2 TPTE2 25348397 N/A physical interaction ComPPI
EPHA2 TES 25348397 N/A physical interaction ComPPI
EPHA2 CTNNB1 18948590 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
EPHA2 EPHA7 22036564 24234451 25348397 physical association anti bait coimmunoprecipitation,comigration in sds page ComPPI,IntAct
EPHA2 BET1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
EPHA2 EZR 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
EPHA2 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
EPHA2 RAB9A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
EPHA2 TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PKM EPHA2 25348397 N/A protein kinase assay ComPPI
DUSP14 EPHA2 25348397 N/A physical interaction ComPPI
EPHA2 EPHA2 14525934 17192257 19525919 24234451 7890684 7982920 N/A experimental interaction detection,x-ray crystallography HPRD,IntAct
EPHA2 SF3A3 24234451 30021884 physical association cross-linking study IntAct
SRC EPHA2 24457997 27898060 inhibition N/A OmniPath
AKT1 EPHA2 17192257 18691976 19369195 19573808 25908849 26158630 27898060 N/A N/A OmniPath
TP53 EPHA2 18431400 27898060 stimulant N/A OmniPath
EPHA2 SHC1 12400011 27898060 stimulant N/A OmniPath
EFNA5 EPHA2 20228801 20505120 27898060 9245480 9330863 stimulant N/A OmniPath
EFNA2 EPHA2 10072375 27898060 8755474 stimulant N/A OmniPath
EFNA1 EPHA2 11248553 14692877 15114347 19525919 19573808 20505120 22244754 27898060 7973638 8139691 8755474 9330863 9576626 stimulant N/A OmniPath
EFNA4 EPHA2 10607706 15114347 27898060 8755474 stimulant N/A OmniPath
EFNA3 EPHA2 12907451 27898060 9330863 stimulant N/A OmniPath
EPHA2 CLDN4 16236711 27898060 N/A N/A OmniPath

Visualization










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