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GENE：HMGCL

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HMGCL
FullNmae 3-hydroxy-3-methylglutaryl-CoA lyase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5005
EnsembleID ENSG00000117305
Uniprot P35914

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HMGCL immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HMGCL GO:0000287,GO:0004419,GO:0004419,GO:0005198,GO:0005739,GO:0005739,GO:0005759,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006552,GO:0006552,GO:0006552,GO:0006629,GO:0007005,GO:0030145,GO:0032991,GO:0046872,GO:0046951,GO:0046951

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HMGCL hsa:3155 path:hsa00280 Valine, leucine and isoleucine degradation - Homo sapiens (human)
HMGCL hsa:3155 path:hsa00650 Butanoate metabolism - Homo sapiens (human)
HMGCL hsa:3155 path:hsa01100 Metabolic pathways - Homo sapiens (human)
HMGCL hsa:3155 path:hsa04146 Peroxisome - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 HMGCL 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A HMGCL 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SMARCA4 HMGCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HMGCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HMGCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HMGCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HMGCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HMGCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HMGCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HMGCL 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000600E6 HMGCL 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
GTF2B HMGCL 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIR HMGCL 25348397 N/A physical interaction ComPPI
DNAJA1 HMGCL 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CAT HMGCL 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FBXO21 HMGCL 25348397 N/A physical interaction ComPPI
TOMM40 HMGCL 25348397 N/A physical interaction ComPPI
HES1 HMGCL 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NTAQ1 HMGCL 25348397 N/A physical interaction ComPPI
HMGCL ADAMTS10 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HMGCL PEX5 25348397 N/A physical interaction ComPPI
HMGCL PNPT1 25348397 N/A physical interaction ComPPI
HMGCL GLS 25348397 N/A physical interaction ComPPI
HMGCL ALAS1 25348397 N/A physical interaction ComPPI
HMGCL MCCC2 25348397 N/A physical interaction ComPPI
HMGCL SIRT4 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct

Visualization










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