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GENE：HMGA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HMGA2
FullNmae high mobility group AT-hook 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5009
EnsembleID ENSG00000149948
Uniprot P52926

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HMGA2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMGA2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMGA2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HMGA2 GO:0000122,GO:0000228,GO:0000976,GO:0001837,GO:0002062,GO:0003131,GO:0003676,GO:0003680,GO:0003680,GO:0003712,GO:0003714,GO:0003906,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0006284,GO:0006325,GO:0006355,GO:0006355,GO:0007049,GO:0008301,GO:0008301,GO:0009615,GO:0010564,GO:0010628,GO:0030261,GO:0031492,GO:0031507,GO:0032993,GO:0035497,GO:0035500,GO:0035501,GO:0035556,GO:0035985,GO:0035987,GO:0035988,GO:0043066,GO:0043392,GO:0043392,GO:0043922,GO:0045444,GO:0045766,GO:0045869,GO:0045892,GO:0045892,GO:0045893,GO:0045893,GO:0045944,GO:0046332,GO:0048333,GO:0048762,GO:0048863,GO:0051301,GO:0051575,GO:0061629,GO:0070742,GO:0071141,GO:0071864,GO:0071902,GO:0090402,GO:2000036,GO:2000036,GO:2000648,GO:2000648,GO:2000773,GO:2001033

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HMGA2 hsa:8091 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
HMGA2 hsa:8091 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMAD4 HMGA2 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 26192618 9389648 interaction type N/A ACSN
HMGA2 SNAI1 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 26192618 8515656 9389648 interaction type N/A ACSN
HMGA2 SNAI2 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 26192618 9389648 interaction type N/A ACSN
HMGA2 ZEB1 11074002 11279127 11792802 12490555 12702545 12743038 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 19839049 20519943 20731704 21199805 21224848 21317430 21614932 21883379 22006115 22406545 225147423 22945800 26192618 9389648 interaction type N/A ACSN
HMGA2 ZEB2 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 26192618 9389648 interaction type N/A ACSN
HMGA2 TWIST1 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 26192618 9389648 interaction type N/A ACSN
NFKB1 HMGA2 12693954 23180781 physical association gst pull down InnateDB
HMGA2 RELA 12693954 23180781 physical association gst pull down InnateDB
BCL2A1 HMGA2 12665576 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR HMGA2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 HMGA2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 HMGA2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYCN HMGA2 16093321 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 HMGA2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 HMGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HMGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HMGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HMGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HMGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 HMGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HMGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HMGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HMGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 HMGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 HMGA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 HMGA2 20007691 trascriptional regulation,stimulation inferred by curator TFlink
SP1 HMGA2 11802722 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 HMGA2 11802722 trascriptional regulation,stimulation inferred by curator TFlink
SP3 HMGA2 11802722 trascriptional regulation,stimulation inferred by curator TFlink
ZNF350 HMGA2 20007691 trascriptional regulation,stimulation inferred by curator TFlink
ZNF382 HMGA2 20682794 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 HMGA2 17437991 \N rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000031E12 HMGA2 17243163 17600087 18403645 \N rna interference,inhibition array technology,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000A07C1 HMGA2 17957144 20395557 \N rna interference,inhibition western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000000B1C9 HMGA2 17437991 \N rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000029979D HMGA2 N/A 17600087 18308936 18413726 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00004900F1 HMGA2 19179606 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000122ED0 HMGA2 N/A 17222355 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000324096 HMGA2 17437991 18927107 20371350 21572407 23318420 23482325 25416803 25600877 26701625 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000031E12 HMGA2 17243163 17600087 18403645 18927107 20371350 21224353 21572407 23446348 23622248 25416803 26701625 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunocytochemistry,clip,clash,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00000A07C1 HMGA2 17600087 17957144 18927107 20371350 20395557 21572407 23318420 25416803 26701625 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000000B1C9 HMGA2 17437991 18927107 20371350 21572407 25416803 26701625 mrna cleavage,inhibition quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000029979D HMGA2 17600087 18308936 18413726 18927107 20371350 21572407 23318420 23446348 25416803 26701625 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000122ED0 HMGA2 17222355 18927107 19088304 20371350 21572407 24392454 25416803 26701625 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00000EED18 HMGA2 19461653 25416803 mrna cleavage,inhibition array technology TarBase
URS00004900F1 HMGA2 19179606 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002367FA HMGA2 19688090 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,experimental interaction detection,quantitative reverse transcription pcr TarBase
URS0000171CD1 HMGA2 22139073 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000029D9F1 HMGA2 25416803 26406941 27095441 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000512C88 HMGA2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000008931A HMGA2 23591597 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000C85B2 HMGA2 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 HMGA2 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000237CBD HMGA2 20371350 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B989F HMGA2 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000052E1A6 HMGA2 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001919B0 HMGA2 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001A7F58 HMGA2 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000002103A HMGA2 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000032EF64 HMGA2 20371350 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000006A1CB HMGA2 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000CBE63 HMGA2 23625920 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00001270D3 HMGA2 25416803 25868853 25919570 26830228 28436711 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001E0AEA HMGA2 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000021202F HMGA2 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004F24A9 HMGA2 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000031B6ED HMGA2 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E2232 HMGA2 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004F4657 HMGA2 25416803 25444913 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000183BED HMGA2 24681352 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000077AED HMGA2 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000157F5 HMGA2 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000013D17D HMGA2 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000006FDD4 HMGA2 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000610EFA HMGA2 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000005E58C HMGA2 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000236310 HMGA2 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000018C928 HMGA2 21572407 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000019F055 HMGA2 21572407 25416803 26701625 26968810 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS00001496AE HMGA2 25416803 26341146 26701625 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000005A8ED HMGA2 25416803 28159956 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000008F0CF HMGA2 25416803 27773820 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000006372A HMGA2 25416803 26239806 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004AF715 HMGA2 25416803 26398017 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000039E1E1 HMGA2 25416803 27383537 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000016D2D4 HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000753AD HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004BCD9C HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002075FA HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003D8730 HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000153377 HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000065D58 HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000005CF5F HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001DE669 HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000116F83 HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A939F HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007A060 HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000237AF9 HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003808EC HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000025EABA HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004AE8D3 HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E177F HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002C02E4 HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004283FE HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000080D0A HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000040FA88 HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002F3336 HMGA2 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NPM1 HMGA2 25348397 N/A physical interaction ComPPI
SMAD1 HMGA2 25348397 N/A physical interaction ComPPI
PRKCA HMGA2 25348397 N/A physical interaction ComPPI
NFATC1 HMGA2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RB1 HMGA2 25348397 N/A physical interaction ComPPI
SMAD3 HMGA2 14525934 18832382 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD5 HMGA2 25348397 N/A physical interaction ComPPI
PRMT1 HMGA2 16293633 24234451 25348397 physical association methyltransferase radiometric assay ComPPI,IntAct
SMAD9 HMGA2 25348397 N/A physical interaction ComPPI
E4F1 HMGA2 25348397 N/A physical interaction ComPPI
CSNK2A1 HMGA2 11034995 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
XRCC6 HMGA2 25348397 N/A physical interaction ComPPI
PA2G4 HMGA2 25348397 N/A physical interaction ComPPI
RELA HMGA2 12693954 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ATM HMGA2 24234451 25348397 26045162 association anti bait coimmunoprecipitation ComPPI,IntAct
CSNK2A2 HMGA2 11034995 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SYNCRIP HMGA2 25348397 N/A physical interaction ComPPI
PSIP1 HMGA2 25348397 N/A physical interaction ComPPI
H3C1 HMGA2 25348397 N/A physical interaction ComPPI
NFKB1 HMGA2 12693954 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PTBP1 HMGA2 25348397 N/A physical interaction ComPPI
PCBP2 HMGA2 25348397 N/A physical interaction ComPPI
PIAS3 HMGA2 11390395 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
HMGA2 PRMT6 16293633 24234451 25348397 physical association far western blotting,physical interaction,methyltransferase radiometric assay ComPPI,IntAct
HMGA2 HDGF 25348397 N/A physical interaction ComPPI
HMGA2 APEX1 25348397 N/A physical interaction ComPPI
HMGA2 OBSL1 25348397 N/A physical interaction ComPPI
HMGA2 CREB1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HMGA2 PCGF1 25348397 N/A physical interaction ComPPI
HMGA2 POU5F1 25348397 N/A physical interaction ComPPI
HMGA2 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HMGA2 H2AX 24234451 25348397 26045162 association anti bait coimmunoprecipitation ComPPI,IntAct
HMGA2 DUX4L9 24234451 25348397 26816005 association pull down ComPPI,IntAct
HMGA2 DUX4 24234451 25348397 26816005 physical association pull down ComPPI,IntAct
CDK1 HMGA2 10636877 14525934 N/A experimental interaction detection HPRD
HMGA2 H1-5 24234451 30021884 physical association cross-linking study IntAct
HMGA2 NFKB1 12693954 27898060 N/A N/A OmniPath
ATM HMGA2 21339738 27898060 stimulant N/A OmniPath
CDK1 HMGA2 10636877 18707149 19413330 19664994 27898060 inhibition N/A OmniPath
HMGA2 RELA 12693954 27898060 N/A N/A OmniPath
HMGA2 E4F1 14645522 27898060 inhibition N/A OmniPath

Visualization










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