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GENE：LRCH3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LRCH3
FullNmae leucine rich repeats and calponin homology domain containing 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:28637
EnsembleID ENSG00000186001
Uniprot Q96II8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LRCH3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LRCH3 GO:0005515,GO:0005737,GO:0005829,GO:0005829,GO:0032185

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR LRCH3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 LRCH3 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 LRCH3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 LRCH3 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 LRCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LRCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LRCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 LRCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 LRCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LRCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LRCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LRCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF LRCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 LRCH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003CF1AD LRCH3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EC1BE LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001481F9 LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B2B LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000043C1C3 LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D793 LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000011166D LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000035925E LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 LRCH3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 LRCH3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000346991 LRCH3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000027080C LRCH3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000041E949 LRCH3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000508C13 LRCH3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075B0F6 LRCH3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000CC005 LRCH3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003883FE LRCH3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000037D7E5 LRCH3 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000000E601 LRCH3 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK2 LRCH3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
LRCH4 LRCH3 25348397 N/A physical interaction ComPPI
YWHAG LRCH3 14525934 15324660 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EGLN3 LRCH3 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
DOCK7 LRCH3 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NTRK1 LRCH3 25348397 N/A physical interaction ComPPI
HNRNPL LRCH3 25348397 N/A physical interaction ComPPI
PARD6A LRCH3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PARD6B LRCH3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CBX5 LRCH3 25348397 N/A physical interaction ComPPI
CALD1 LRCH3 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VCPIP1 LRCH3 25348397 N/A physical interaction ComPPI
DOCK8 LRCH3 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DCAF7 LRCH3 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
PAN2 LRCH3 25348397 N/A physical interaction ComPPI
DYRK1A LRCH3 25348397 N/A physical interaction ComPPI
CEP57 LRCH3 25348397 N/A physical interaction ComPPI
MOB1A LRCH3 24234451 24255178 25348397 colocalization,association anti tag coimmunoprecipitation,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RSU1 LRCH3 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SUGT1 LRCH3 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ACTA1 LRCH3 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIH1D1 LRCH3 25348397 N/A physical interaction ComPPI
LIMA1 LRCH3 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRCH3 BASP1 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRCH3 CORO1C 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRCH3 CRLF3 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRCH3 DBN1 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRCH3 DOCK6 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRCH3 LRCH1 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRCH3 LRCH2 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRCH3 TPM1 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRCH3 MOB1B 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LRCH3 CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRCH3 PPP4R3A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRCH3 MLKL 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRCH3 TMOD3 25348397 N/A physical interaction ComPPI
NUDCD1 LRCH3 24234451 29021621 association anti tag coimmunoprecipitation IntAct

Source Target Pmid Interactiontype Methods Database
URS00009B5AAC LRCH3 27087310 direct interaction,inhibition N/A NPInter

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