Gene Information gene info

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GENE：MED6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MED6
FullNmae mediator complex subunit 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:19970
EnsembleID ENSG00000133997
Uniprot O75586

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MED6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MED6 GO:0000151,GO:0001223,GO:0003677,GO:0003713,GO:0003713,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0006357,GO:0016020,GO:0016567,GO:0016592,GO:0016592,GO:0016592,GO:0032968,GO:0035019,GO:0045944,GO:0051123,GO:0060261,GO:0061630,GO:0070847,GO:0070847

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 MED6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MED6 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 MED6 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MED6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MED6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MED6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MED6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MED6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 MED6 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
RARA MED6 14525934 15808511 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TP53BP1 MED6 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
SKP1 MED6 25348397 N/A physical interaction ComPPI
MED21 MED6 11118219 15710619 22939629 25348397 27898060 9710620 9734358 N/A physical interaction ComPPI,OmniPath
MED8 MED6 12584197 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
EHMT2 MED6 25348397 N/A physical interaction ComPPI
SMAD1 MED6 12167862 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
FBXW7 MED6 25348397 N/A physical interaction ComPPI
SMAD2 MED6 12167862 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
VDR MED6 25348397 N/A physical interaction ComPPI
SMAD3 MED6 25348397 N/A physical interaction ComPPI
THRA MED6 25348397 N/A physical interaction ComPPI
MED1 MED6 25348397 N/A physical interaction ComPPI
MED24 MED6 25348397 N/A physical interaction ComPPI
PARP1 MED6 14525934 15808511 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMARCA4 MED6 25348397 N/A physical interaction ComPPI
SREBF1 MED6 25348397 N/A pull down,pull down,physical interaction,physical interaction ComPPI
SREBF2 MED6 16799563 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
CTDP1 MED6 25348397 N/A physical interaction ComPPI
CSNK2A2 MED6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL1 MED6 22479149 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MED30 MED6 25348397 N/A physical interaction ComPPI
MED9 MED6 14525934 14638676 15175163 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
MED23 MED6 25348397 N/A physical interaction ComPPI
MED28 MED6 24234451 24882805 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED14 MED6 10082564 11555651 25348397 26344197 27898060 9234719 9734358 9891034 N/A physical interaction ComPPI,OmniPath
MED12 MED6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK8 MED6 23602568 24234451 25348397 26496610 29568061 association anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification,proximity-dependent biotin identification ComPPI,IntAct
MED13 MED6 25348397 N/A physical interaction ComPPI
BIRC5 MED6 25348397 N/A physical interaction ComPPI
ESR1 MED6 25348397 N/A physical interaction ComPPI
ESR2 MED6 25348397 N/A physical interaction ComPPI
MED6 MED10 12584197 14576168 15175163 24234451 24882805 25348397 association,physical association anti tag coimmunoprecipitation,electron microscopy,physical interaction,ion exchange chromatography ComPPI,IntAct
MED6 MED19 14576168 15175163 21729782 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED6 ZC3H13 25348397 N/A physical interaction ComPPI
MED6 BCL6 25348397 N/A physical interaction ComPPI
MED6 SUZ12 25348397 N/A physical interaction ComPPI
MED6 MED4 25348397 N/A physical interaction ComPPI
MED6 CCNC 25348397 N/A physical interaction ComPPI
MED6 CDK19 15175163 23602568 24234451 25348397 association,physical association physical interaction,ion exchange chromatography,tandem affinity purification ComPPI,IntAct
MED6 TARDBP 25348397 N/A physical interaction ComPPI
MED6 MED20 25348397 N/A physical interaction ComPPI
MED6 EGR1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED6 POLR2G 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED6 KIF15 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MED18 MED6 24234451 24882805 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPL11 MED6 24234451 30021884 physical association cross-linking study IntAct

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