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GENE：MCL1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MCL1
FullNmae MCL1 apoptosis regulator, BCL2 family member
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6943
EnsembleID ENSG00000143384
Uniprot Q07820

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MCL1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MCL1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MCL1 ferroptosis 38485916 Studies have identified the signal transducer and activator of transcription 3 (STAT3) and myeloid cell leukemia-1 (MCL1) as potential targets for sorafenib, which exhibits activities in inducing ferroptosis. retulator signature
MCL1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MCL1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MCL1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
MCL1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MCL1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
MCL1 anoikis 23912151 Mcl-1, Cav-1, Bcl-(xL), cFLIP and 14-3-3zeta are suppressors of anoikis, and their upregulation confers anoikis resistance to cancer cells. retulator signature

Go Annotation:

GeneSymbol Go id
MCL1 GO:0001709,GO:0001836,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005741,GO:0005829,GO:0005829,GO:0006974,GO:0008053,GO:0008320,GO:0008630,GO:0010507,GO:0015267,GO:0016020,GO:0016020,GO:0019725,GO:0034097,GO:0042803,GO:0043065,GO:0043065,GO:0043066,GO:0046982,GO:0046982,GO:0051434,GO:0071806,GO:0097136,GO:0097136,GO:0097192,GO:0097192,GO:1903378,GO:2000811,GO:2001240

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MCL1 hsa:4170 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
MCL1 hsa:4170 path:hsa04210 Apoptosis - Homo sapiens (human)
MCL1 hsa:4170 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
MCL1 hsa:4170 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MCL1 BMF 11546872 23850759 26192618 association N/A ACSN
MCL1 BBC3 11463391 11463392 23430059 23850759 26192618 association N/A ACSN
MCL1 BCL2L11 15486085 15724238 23430059 23850759 26192618 association N/A ACSN
MCL1 BAK1 20501829 22039431 23430059 23850759 26192618 interaction type N/A ACSN
TRAF2 MCL1 11274345 12847084 15592525 17462996 18641653 19392652 19509052 21133840 21232017 23430059 23850759 24378531 26192618 26587781 interaction type N/A ACSN
GZMB MCL1 10364179 10805722 11062502 11085742 11085743 11287608 11583622 11832478 14499263 15014070 15536084 15607806 15637055 15713684 16106370 18287025 20189481 23180781 24248158 24795729 26192618 8432729 9727492 interaction type,protein cleavage protease assay ACSN,InnateDB
USP9X MCL1 20023629 26192618 interaction type N/A ACSN
STAT3 MCL1 10347215 11160159 12223527 14607900 14670306 15218058 15356132 15573129 15805299 16418395 18208354 18776941 19380816 19808698 20093776 20237412 20406969 20581311 21840487 23124025 23180781 23454751 23953057 24857661 26192618 27216177 28186502 7543512 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
BAX MCL1 14766748 20709625 21641962 22039431 23064052 23180781 23377657 23430059 23850759 26192618 26587781 7644501 8358790 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
BCL2 MCL1 11704864 17446862 22039431 23064052 23377657 23430059 23850759 26192618 8929532 interaction type N/A ACSN
MCL1 CHUK 11274345 12847084 15592525 17462996 18641653 19392652 19509052 21133840 21232017 23430059 23850759 24378531 26192618 26587781 interaction type N/A ACSN
MCL1 IKBKB 11274345 12847084 15592525 17462996 18641653 19392652 19509052 21133840 21232017 23430059 23850759 24378531 26192618 26587781 interaction type N/A ACSN
MCL1 SDHC 11274345 12847084 15592525 17462996 18641653 19392652 19509052 21133840 21232017 23430059 23850759 24378531 26192618 26587781 interaction type N/A ACSN
MAPK8 MCL1 17670986 23180781 phosphorylation reaction in-gel kinase assay InnateDB
MAPK9 MCL1 17670986 23180781 phosphorylation reaction in-gel kinase assay InnateDB
MAPK10 MCL1 17670986 23180781 phosphorylation reaction in-gel kinase assay InnateDB
PIN1 MCL1 17670986 23180781 phosphorylation reaction gst pull down InnateDB
GSK3B MCL1 17387146 23180781 physical association anti tag coimmunoprecipitation InnateDB
BCL2L11 MCL1 15014070 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP3 MCL1 15014070 23180781 protein cleavage protease assay InnateDB
IKZF1 MCL1 23180781 24522918 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR MCL1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 MCL1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ELK1 MCL1 21258408 9880563 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ETS1 MCL1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MCL1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MCL1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MCL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MCL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MCL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A MCL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MCL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 MCL1 22128141 trascriptional regulation,stimulation inferred by curator TFlink
ATM MCL1 20164679 trascriptional regulation,stimulation inferred by curator TFlink
DDIT3 MCL1 22253918 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MCL1 11705881 trascriptional regulation,stimulation inferred by curator TFlink
ELK4 MCL1 21846680 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 MCL1 18223231 18761050 19303700 trascriptional regulation,stimulation inferred by curator TFlink
RELA MCL1 18223231 18761050 19303700 trascriptional regulation,stimulation inferred by curator TFlink
SIRT1 MCL1 22483777 trascriptional regulation,stimulation inferred by curator TFlink
SRF MCL1 9880563 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 MCL1 15184887 15469392 15805299 16317687 16432172 17880940 18790750 19523441 19595668 20654581 22313388 22465052 trascriptional regulation,stimulation inferred by curator TFlink
TP53 MCL1 19411072 trascriptional regulation,stimulation inferred by curator TFlink
MYC MCL1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000032BD73 MCL1 19654003 20056941 \N rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000521626 MCL1 20829195 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000171CD1 MCL1 18362358 rna interference,inhibition array technology miRSponge
URS0000367985 MCL1 18381414 20829195 23546867 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000AA464 MCL1 20103677 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS000029D9F1 MCL1 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000076995 MCL1 19850741 20041405 20643754 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS0000272A3D MCL1 20041405 20643754 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS00003CF1AD MCL1 19096009 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000B0E50 MCL1 20829195 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS000006DA05 MCL1 20829195 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS000032BD73 MCL1 19654003 20056941 22743998 24391788 25416803 26276722 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS0000171CD1 MCL1 18362358 19498445 22743998 25416803 mrna cleavage,inhibition array technology miRDeathDB,TarBase
URS00000AA464 MCL1 20103677 20304954 22743998 25034398 25416803 26526790 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS000029D9F1 MCL1 19070389 22743998 mrna cleavage,inhibition N/A miRDeathDB
URS0000367985 MCL1 18381414 20829195 23546867 23588298 24356455 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000076995 MCL1 19850741 20041405 20371350 20643754 21572407 23446348 24155920 24398324 25006537 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS0000272A3D MCL1 20041405 20371350 20643754 21572407 23001726 23446348 23894561 24398324 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,nucleotide sequence identification,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS00003CF1AD MCL1 19096009 24136787 25416803 26701625 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS00000B0E50 MCL1 20829195 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000006DA05 MCL1 20829195 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000521626 MCL1 20829195 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000016C318 MCL1 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS000021D7C8 MCL1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000003ABC4 MCL1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00003D5391 MCL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005CF5F MCL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000D0BB4 MCL1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000023BE29 MCL1 23551751 23557151 23592263 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS0000042E1F MCL1 22473208 23594563 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS000075AAA0 MCL1 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED MCL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 MCL1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002E1509 MCL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 MCL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000008DA94 MCL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 MCL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000045147B MCL1 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF MCL1 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA MCL1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 MCL1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 MCL1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 MCL1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 MCL1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 MCL1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA MCL1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 MCL1 25416803 26297542 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000346991 MCL1 25416803 26457704 27725905 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 MCL1 25416803 28097098 mrna cleavage,inhibition array technology TarBase
URS000003FD55 MCL1 25416803 27197185 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000009A9A2 MCL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000044FD7 MCL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000170D8B MCL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000192A75 MCL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000004CA3 MCL1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 MCL1 22135298 phosphorylation N/A PhosphoSite
CDK1 MCL1 22135298 phosphorylation N/A PhosphoSite
GSK3B MCL1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
CDK2 MCL1 22135298 phosphorylation N/A PhosphoSite
MAPK1 MCL1 22135298 phosphorylation N/A PhosphoSite
MAPK8 MCL1 22135298 phosphorylation N/A PhosphoSite
TNKS MCL1 25361965 interaction type N/A PTMCode2
MCL1 TNKS 25361965 interaction type N/A PTMCode2
MCL1 GSK3B 25361965 interaction type N/A PTMCode2
BCL2L11 MCL1 25361965 interaction type N/A PTMCode2
MCL1 BCL2L11 25361965 interaction type N/A PTMCode2
BCL2L1 MCL1 25361965 interaction type N/A PTMCode2
MCL1 BCL2L1 25361965 interaction type N/A PTMCode2
PIN1 MCL1 25361965 interaction type N/A PTMCode2
MCL1 PIN1 25361965 interaction type N/A PTMCode2
MCL1 IER3 25361965 interaction type N/A PTMCode2
IER3 MCL1 25361965 interaction type N/A PTMCode2
BECN1 MCL1 25361965 interaction type N/A PTMCode2
MCL1 BECN1 25361965 interaction type N/A PTMCode2
BAD MCL1 25361965 interaction type N/A PTMCode2
MCL1 BAD 25361965 interaction type N/A PTMCode2
BIK MCL1 25361965 interaction type N/A PTMCode2
MCL1 BIK 25361965 interaction type N/A PTMCode2
HUWE1 MCL1 25361965 interaction type N/A PTMCode2
MCL1 HUWE1 25361965 interaction type N/A PTMCode2
CASP3 MCL1 25361965 interaction type N/A PTMCode2
MCL1 CASP3 25361965 interaction type N/A PTMCode2
BCL2 MCL1 25361965 interaction type N/A PTMCode2
MCL1 BCL2 25361965 interaction type N/A PTMCode2
BAX MCL1 25361965 interaction type N/A PTMCode2
MCL1 BAX 25361965 interaction type N/A PTMCode2
MAPK10 MCL1 25361965 interaction type N/A PTMCode2
MCL1 MAPK10 25361965 interaction type N/A PTMCode2
BMF MCL1 25361965 interaction type N/A PTMCode2
MCL1 BMF 25361965 interaction type N/A PTMCode2
PMAIP1 MCL1 25361965 interaction type N/A PTMCode2
MCL1 PMAIP1 25361965 interaction type N/A PTMCode2
BID MCL1 25361965 interaction type N/A PTMCode2
MCL1 BID 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 MCL1 25348397 N/A physical interaction ComPPI
BCL2L11 MCL1 10837489 14525934 16213503 16697956 17525735 20085765 21132008 21199865 21507240 22516262 23245996 24234451 25348397 26859456 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,surface plasmon resonance,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
HSPA8 MCL1 25348397 N/A physical interaction ComPPI
BAG3 MCL1 25348397 N/A physical interaction ComPPI
PCNA MCL1 10978339 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
TRAF6 MCL1 25340740 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ACTB MCL1 25348397 N/A anti tag coimmunoprecipitation ComPPI
SKP1 MCL1 25348397 N/A physical interaction ComPPI
BIK MCL1 14525934 16697956 24234451 25348397 N/A experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro ComPPI,HPRD,IntAct
BCL2L1 MCL1 14525934 15077116 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BAD MCL1 10579309 10837489 11483855 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAPK1 MCL1 14525934 15241487 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
LYN MCL1 25348397 N/A physical interaction ComPPI
FBXW7 MCL1 25348397 N/A physical interaction ComPPI
CASP3 MCL1 14525934 15637055 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FLG MCL1 25348397 N/A physical interaction ComPPI
GSK3B MCL1 14525934 16543145 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GAPDH MCL1 25348397 N/A anti tag coimmunoprecipitation ComPPI
PRKAA1 MCL1 25348397 N/A physical interaction ComPPI
UBB MCL1 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
UBC MCL1 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
RPS27A MCL1 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 MCL1 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
BTRC MCL1 25348397 N/A physical interaction ComPPI
CAV1 MCL1 22277751 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct,OmniPath
HSPA1A MCL1 25348397 N/A physical interaction ComPPI
HSPA1B MCL1 25348397 N/A physical interaction ComPPI
MCL1 BAX 10837489 14525934 15077116 17525735 18981409 19968986 21199865 21458670 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,fluorescence technology,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct
MCL1 DAD1 10965038 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
MCL1 BAK1 10579309 10837489 14525934 15077116 15901672 17097560 18040043 19968986 20023629 21132008 22516262 23680104 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
MCL1 TNKS 12475993 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
MCL1 BOK 10579309 14525934 25348397 9356461 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
MCL1 BMF 11546872 14525934 16697956 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
MCL1 PMAIP1 14525934 15694340 15901672 16697956 20085765 21132008 21454712 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,physical interaction,in vitro ComPPI,HPRD,IntAct
MCL1 TPT1 11598139 12149273 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
MCL1 VDAC1 14525934 15637055 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MCL1 GSK3A 14525934 16543145 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MCL1 HUWE1 14525934 16213503 20023629 21507240 24234451 25348397 ubiquitination reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
MCL1 BBC3 16697956 22516262 24234451 25348397 26431330 association anti bait coimmunoprecipitation,fluorescence polarization spectroscopy,physical interaction,in vitro ComPPI,IntAct
MCL1 HRK 15031724 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MCL1 BID 14525934 15637055 16697956 19074266 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,mass spectrometry study of hydrogen/deuterium exchange ComPPI,HPRD,IntAct
MCL1 BBC3 14525934 16697956 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MCL1 MAPK10 25348397 N/A physical interaction ComPPI
MCL1 USP9X 20023629 24234451 25348397 deubiquitination reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,enzymatic study,deubiquitinase assay ComPPI,IntAct
MCL1 UHRF2 21952639 24234451 25348397 physical association physical interaction,antibody array ComPPI,IntAct
MCL1 HSPA4 25348397 N/A physical interaction ComPPI
MCL1 ATG12 25348397 N/A physical interaction ComPPI
MCL1 BAG4 25348397 N/A physical interaction ComPPI
MCL1 BECN1 21139567 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MCL1 AGO2 25348397 N/A physical interaction ComPPI
MCL1 TP53 25348397 N/A physical interaction ComPPI
MCL1 PRKN 25348397 N/A physical interaction ComPPI
MCL1 PINK1 25348397 N/A physical interaction ComPPI
MCL1 NXF1 25348397 N/A physical interaction ComPPI
MCL1 EDNRA 25348397 N/A physical interaction ComPPI
MCL1 PRKAG1 25348397 N/A physical interaction ComPPI
MCL1 STARD9 25348397 N/A physical interaction ComPPI
MCL1 CPT2 25348397 N/A physical interaction ComPPI
MCL1 PRKAB1 25348397 N/A physical interaction ComPPI
MCL1 PRKAB2 25348397 N/A physical interaction ComPPI
MCL1 ASPRV1 25348397 N/A physical interaction ComPPI
MCL1 TRIM11 25348397 N/A physical interaction ComPPI
MCL1 ECM1 25348397 N/A physical interaction ComPPI
MCL1 SERPINB7 25348397 N/A physical interaction ComPPI
MCL1 UNK 25348397 N/A physical interaction ComPPI
MCL1 UBXN6 25348397 N/A physical interaction ComPPI
MCL1 DUSP22 25348397 N/A physical interaction ComPPI
MCL1 EDEM2 25348397 N/A physical interaction ComPPI
MCL1 ARG1 25348397 N/A physical interaction ComPPI
MCL1 RANBP6 25348397 N/A physical interaction ComPPI
MCL1 C5AR2 25348397 N/A physical interaction ComPPI
MCL1 CUL1 25348397 N/A physical interaction ComPPI
MCL1 FBXW11 25348397 N/A physical interaction ComPPI
MCL1 BCL2 21139567 24234451 25348397 27898060 7937747 colocalization two hybrid,cosedimentation through density gradient,physical interaction ComPPI,IntAct,OmniPath
MCL1 IER3 25348397 N/A two hybrid ComPPI
MCL1 ATPAF1 19968986 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
MCL1 HSPD1 20627101 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
MCL1 TNKS2 22153077 24234451 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
MCL1 RTL10 23055042 24234451 25348397 association,physical association anti tag coimmunoprecipitation ComPPI,IntAct
MCL1 KCNF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX8 MCL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
COX4I1 MCL1 25348397 N/A anti tag coimmunoprecipitation ComPPI
MCL1 MCL1 10837489 14525934 N/A experimental interaction detection HPRD
CHRM4 MCL1 24234451 28298427 physical association ubiquitin reconstruction IntAct
SEPTIN9 MCL1 24234451 30021884 physical association cross-linking study IntAct
MCL1 TRIM17 22976837 27898060 N/A N/A OmniPath
MAPK10 MCL1 17670986 27898060 stimulant N/A OmniPath
MAPK9 MCL1 17670986 27898060 N/A N/A OmniPath
CASP3 MCL1 15014070 15637055 27898060 inhibition N/A OmniPath
BMF MCL1 11546872 15694340 15721256 16697956 27898060 inhibition N/A OmniPath
MCL1 PIN1 17670986 27898060 N/A N/A OmniPath
PIN1 MCL1 17670986 27898060 N/A N/A OmniPath
CDK2 MCL1 12223490 15241487 17463001 18676833 20526282 21368833 21368834 25825522 25915848 26205817 26219338 27898060 N/A N/A OmniPath
MCL1 BAD 10579309 10837489 11483855 11571294 15694340 27898060 inhibition,stimulant N/A OmniPath
MCL1 BAK1 10579309 10837489 15077116 15637055 15901672 17097560 17289999 19148187 19968986 21613222 23680104 26186194 27898060 inhibition N/A OmniPath
GSK3A MCL1 16543145 27898060 inhibition N/A OmniPath
MAPK3 MCL1 15241487 18676833 27898060 stimulant N/A OmniPath
TP53 MCL1 11832478 18208354 27898060 inhibition,stimulant N/A OmniPath
BBC3 MCL1 15694340 27898060 inhibition N/A OmniPath
PMAIP1 MCL1 15694340 15721256 15901672 16697956 19148187 21139584 21353614 21454712 21613222 22219388 22361683 23341456 27898060 inhibition N/A OmniPath
BCL2L11 MCL1 10198631 10837489 15014070 15694340 15721256 15989957 16213503 16697956 17097560 17525735 19148187 19150432 19622586 20074640 21507240 21613222 26186194 26859456 27898060 9731710 inhibition N/A OmniPath
CDK1 MCL1 18676833 20526282 27898060 stimulant N/A OmniPath
MCL1 BECN1 21139567 21353614 22219388 27898060 inhibition N/A OmniPath
MAPK1 MCL1 12223490 15241487 17463001 18676833 27898060 stimulant N/A OmniPath
MCL1 BAX 10837489 14766748 15077116 17289999 19148187 21199865 21458670 21566062 26186194 27898060 inhibition N/A OmniPath
GSK3B MCL1 16543145 17387146 27898060 inhibition N/A OmniPath
MAPK8 MCL1 12223490 17670986 18676833 27898060 inhibition,stimulant N/A OmniPath
BBC3 MCL1 15694340 15721256 16697956 21613222 21730980 26186194 27898060 inhibition N/A OmniPath

Visualization










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