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GENE：MGMT

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MGMT
FullNmae O-6-methylguanine-DNA methyltransferase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7059
EnsembleID ENSG00000170430
Uniprot P16455

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MGMT parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MGMT GO:0003677,GO:0003908,GO:0005634,GO:0005654,GO:0005654,GO:0006266,GO:0006281,GO:0006306,GO:0006307,GO:0008168,GO:0009008,GO:0016020,GO:0043066,GO:0046872,GO:2000781

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR MGMT 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MGMT 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MGMT 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MGMT 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MGMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MGMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MGMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MGMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MGMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MGMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MGMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MGMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MGMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MGMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 MGMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MGMT 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DNMT1 MGMT 18555750 trascriptional regulation,stimulation inferred by curator TFlink
EP300 MGMT 22675172 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 MGMT 18555750 trascriptional regulation,stimulation inferred by curator TFlink
JUN MGMT 9731508 trascriptional regulation,stimulation inferred by curator TFlink
MBD1 MGMT 15657354 trascriptional regulation,stimulation inferred by curator TFlink
MECP2 MGMT 15657354 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 MGMT 22675172 trascriptional regulation,stimulation inferred by curator TFlink
RELA MGMT 22675172 trascriptional regulation,stimulation inferred by curator TFlink
SP1 MGMT 22675172 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 MGMT 22675172 trascriptional regulation,stimulation inferred by curator TFlink
TP53 MGMT 17564708 19846904 20525765 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000236310 MGMT 22570426 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000236310 MGMT 22570426 23340988 25416803 27057640 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000170CF4 MGMT 24147153 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000153377 MGMT 24147153 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000045147B MGMT 23340988 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00004900F1 MGMT 23340988 25416803 27595933 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000081E1F MGMT 25416803 27057640 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr TarBase
URS0000007340 MGMT 25416803 27057640 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
MSH2 MGMT 25361965 interaction type N/A PTMCode2
MGMT MSH2 25361965 interaction type N/A PTMCode2
CDKN1A MGMT 25361965 interaction type N/A PTMCode2
MGMT CDKN1A 25361965 interaction type N/A PTMCode2
MGMT TOP1 25361965 interaction type N/A PTMCode2
TOP1 MGMT 25361965 interaction type N/A PTMCode2
POLD1 MGMT 25361965 interaction type N/A PTMCode2
MGMT POLD1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ORC1 MGMT 25348397 N/A physical interaction ComPPI
HNRNPC MGMT 25348397 N/A physical interaction ComPPI
EIF3H MGMT 25348397 N/A physical interaction ComPPI
ANXA1 MGMT 25348397 N/A physical interaction ComPPI
VIM MGMT 25348397 N/A physical interaction ComPPI
PCNA MGMT 25348397 N/A physical interaction ComPPI
CDKN1A MGMT 25348397 N/A physical interaction ComPPI
SET MGMT 25348397 N/A physical interaction ComPPI
ACTB MGMT 25348397 N/A physical interaction ComPPI
FBXO2 MGMT 25348397 N/A physical interaction ComPPI
MCM2 MGMT 25348397 N/A physical interaction ComPPI
SLC25A6 MGMT 25348397 N/A physical interaction ComPPI
HSP90AB1 MGMT 25348397 N/A physical interaction ComPPI
H2AC11 MGMT 25348397 N/A physical interaction ComPPI
H4C1 MGMT 25348397 N/A physical interaction ComPPI
PRKCA MGMT 10667577 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PRKDC MGMT 25348397 N/A physical interaction ComPPI
CREBBP MGMT 11564893 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
EP300 MGMT 11564893 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PRKACA MGMT 10667577 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
KPNB1 MGMT 25348397 N/A physical interaction ComPPI
YWHAZ MGMT 25348397 N/A physical interaction ComPPI
UBB MGMT 25348397 N/A physical interaction ComPPI
HSP90AA1 MGMT 16226712 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PHB MGMT 25348397 N/A physical interaction ComPPI
PRKCH MGMT 25348397 N/A physical interaction ComPPI
PTPN4 MGMT 25348397 N/A physical interaction ComPPI
CSNK2A1 MGMT 10667577 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
XRCC6 MGMT 25348397 N/A physical interaction ComPPI
EEF1A1 MGMT 25348397 N/A physical interaction ComPPI
DDX5 MGMT 25348397 N/A physical interaction ComPPI
PKM MGMT 25348397 N/A physical interaction ComPPI
BRCA2 MGMT 25348397 N/A physical interaction ComPPI
RNF8 MGMT 25348397 N/A physical interaction ComPPI
RPLP1 MGMT 25348397 N/A physical interaction ComPPI
HNRNPA2B1 MGMT 25348397 N/A physical interaction ComPPI
CSNK2A2 MGMT 25348397 N/A physical interaction ComPPI
SMC1A MGMT 25348397 N/A physical interaction ComPPI
CDK2 MGMT 25348397 N/A physical interaction ComPPI
H3-4 MGMT 25348397 N/A physical interaction ComPPI
ANXA2 MGMT 25348397 N/A physical interaction ComPPI
POLD1 MGMT 25348397 N/A physical interaction ComPPI
MYO7A MGMT 25348397 N/A physical interaction ComPPI
CCNB1 MGMT 25348397 N/A physical interaction ComPPI
TUBB4B MGMT 25348397 N/A physical interaction ComPPI
SSRP1 MGMT 25348397 N/A physical interaction ComPPI
PSME2 MGMT 25348397 N/A physical interaction ComPPI
SRP9 MGMT 25348397 N/A physical interaction ComPPI
PRPF4 MGMT 25348397 N/A physical interaction ComPPI
CDK12 MGMT 25348397 N/A physical interaction ComPPI
ESR1 MGMT 25348397 N/A physical interaction ComPPI
MCM3 MGMT 25348397 N/A physical interaction ComPPI
TOP1 MGMT 25348397 N/A physical interaction ComPPI
IL25 MGMT 25348397 N/A physical interaction ComPPI
EEF1B2 MGMT 25348397 N/A physical interaction ComPPI
EEF1A2 MGMT 25348397 N/A physical interaction ComPPI
RPS15A MGMT 25348397 N/A physical interaction ComPPI
PSMD9 MGMT 25348397 N/A physical interaction ComPPI
DDX24 MGMT 25348397 N/A physical interaction ComPPI
MSH2 MGMT 25348397 N/A physical interaction ComPPI
FBL MGMT 25348397 N/A physical interaction ComPPI
SLC25A4 MGMT 25348397 N/A physical interaction ComPPI
TUBA1C MGMT 25348397 N/A physical interaction ComPPI
CDK10 MGMT 25348397 N/A physical interaction ComPPI
EEF1A1P5 MGMT 25348397 N/A physical interaction ComPPI
FANCA MGMT 25348397 N/A physical interaction ComPPI
ANXA2P2 MGMT 25348397 N/A physical interaction ComPPI
NCL MGMT 25348397 N/A physical interaction ComPPI
CDK1 MGMT 25348397 N/A physical interaction ComPPI
HSP90AA2P MGMT 25348397 N/A physical interaction ComPPI
MGMT USP19 25348397 N/A physical interaction ComPPI
MGMT FBXO27 25348397 N/A physical interaction ComPPI
MGMT CDKL5 25348397 N/A physical interaction ComPPI
MGMT WNT9B 25348397 N/A physical interaction ComPPI
MGMT PABPC3 25348397 N/A physical interaction ComPPI
MGMT ANP32E 25348397 N/A physical interaction ComPPI
TTPA MGMT 25348397 N/A physical interaction ComPPI
UBA1 MGMT 14525934 27898060 8573590 N/A experimental interaction detection HPRD,OmniPath

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