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GENE：MUC1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MUC1
FullNmae mucin 1, cell surface associated
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7508
EnsembleID ENSG00000185499
Uniprot P15941

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MUC1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MUC1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MUC1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MUC1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MUC1 GO:0000785,GO:0000978,GO:0002039,GO:0003712,GO:0005515,GO:0005615,GO:0005634,GO:0005796,GO:0005886,GO:0005886,GO:0006977,GO:0006978,GO:0010944,GO:0016324,GO:0031982,GO:0033629,GO:0036003,GO:0043618,GO:0051179,GO:0070062,GO:0070062,GO:1902166

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CTNNB1 MUC1 14766232 16546130 17524503 23180781 physical association anti tag coimmunoprecipitation InnateDB
GSK3B MUC1 11152665 23180781 9819408 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
LCK MUC1 14766232 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
ZAP70 MUC1 14766232 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
LGALS3 MUC1 17090543 19556244 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
EGFR MUC1 17889671 23180781 physical association anti tag coimmunoprecipitation InnateDB
MUC1 LYN 12750561 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKG MUC1 18037881 23180781 physical association gst pull down InnateDB
MUC1 MAPK8 24055030 phosphorylation reaction,stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 MUC1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC MUC1 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MUC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MUC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MUC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 MUC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR MUC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
AR MUC1 21308711 trascriptional regulation,stimulation inferred by curator TFlink
GATA1 MUC1 17078870 trascriptional regulation,stimulation inferred by curator TFlink
GATA3 MUC1 17078870 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A MUC1 19141292 trascriptional regulation,stimulation inferred by curator TFlink
PIAS1 MUC1 17717071 trascriptional regulation,stimulation inferred by curator TFlink
PIAS2 MUC1 17717071 trascriptional regulation,stimulation inferred by curator TFlink
PIAS3 MUC1 17717071 trascriptional regulation,stimulation inferred by curator TFlink
PIAS4 MUC1 17717071 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 MUC1 17151127 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 MUC1 17151127 19578748 21325207 trascriptional regulation,stimulation inferred by curator TFlink
ZEB1 MUC1 12161443 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 MUC1 N/A trascriptional regulation,stimulation inferred by curator TFlink
CREB1 MUC1 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARA MUC1 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5A MUC1 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5B MUC1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002971AB MUC1 20514397 rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00004F4657 MUC1 19996288 20407606 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS00004F4657 MUC1 19996288 20407606 24157791 25416803 25961369 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00002971AB MUC1 20514397 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 MUC1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000009262D MUC1 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS00000AD002 MUC1 23590309 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000076995 MUC1 25416803 26036346 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000007A060 MUC1 25416803 26036346 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKCD MUC1 22135298 phosphorylation N/A PhosphoSite
PDGFRB MUC1 22135298 phosphorylation N/A PhosphoSite
SRC MUC1 22135298 phosphorylation N/A PhosphoSite
GSK3B MUC1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
TMEM199 MUC1 25348397 N/A physical interaction ComPPI
VAMP2 MUC1 25348397 N/A physical interaction ComPPI
HBD MUC1 25348397 N/A physical interaction ComPPI
NUP62 MUC1 17500061 25348397 27898060 N/A physical interaction ComPPI,OmniPath
BMI1 MUC1 25348397 N/A physical interaction ComPPI
CTNND1 MUC1 11181067 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
ERBB2 MUC1 11278868 12939402 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
ERBB4 MUC1 11278868 12939402 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TBP MUC1 25348397 N/A physical interaction ComPPI
LYN MUC1 12750561 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SRC MUC1 11152665 11483589 14525934 21798038 24234451 25348397 association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
SOS1 MUC1 11278868 14525934 25348397 7664271 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PRKCD MUC1 11877440 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
GRB2 MUC1 14525934 20936779 24234451 25348397 7664271 physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,HPRD,IntAct
JUN MUC1 20697347 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
EP300 MUC1 22869720 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HIF1A MUC1 22869720 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
U2AF2 MUC1 22905162 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,proximity ligation assay ComPPI,IntAct,OmniPath
GSK3B MUC1 14525934 25348397 9819408 N/A experimental interaction detection,physical interaction ComPPI,HPRD
JUP MUC1 12939402 14525934 25348397 9139698 N/A experimental interaction detection,physical interaction ComPPI,HPRD
APC MUC1 14525934 15020226 25348397 27898060 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
IKBKB MUC1 25348397 N/A physical interaction ComPPI
TNFRSF1A MUC1 25348397 N/A physical interaction ComPPI
PPARG MUC1 25348397 N/A physical interaction ComPPI
MET MUC1 22962849 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
EGFR MUC1 11278868 11483589 14525934 21258405 24234451 24658140 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,cross-linking study,experimental interaction detection,ubiquitin reconstruction,physical interaction,luminescence based mammalian interactome mapping ComPPI,HPRD,IntAct
CTNNB1 MUC1 11152665 11483589 11877440 12750561 14525934 15221004 25348397 9139698 N/A experimental interaction detection,physical interaction ComPPI,HPRD
GALNT4 MUC1 25348397 N/A physical interaction ComPPI
ESR1 MUC1 16427018 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TNFSF9 MUC1 25348397 N/A physical interaction ComPPI
GALNT12 MUC1 12135769 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
ACTA2 MUC1 25348397 N/A physical interaction ComPPI
TMEM67 MUC1 25348397 N/A physical interaction ComPPI
ATP6V0A2 MUC1 25348397 N/A physical interaction ComPPI
ABL1 MUC1 14525934 16888623 24234451 25348397 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,protein kinase assay,imaging technique ComPPI,HPRD,IntAct
TP53 MUC1 15710329 25348397 27898060 N/A physical interaction ComPPI,OmniPath
IL4I1 MUC1 25348397 N/A physical interaction ComPPI
ERBB3 MUC1 11278868 12939402 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MUC1 IKBKG 25348397 N/A physical interaction ComPPI
MUC1 IPO5 25348397 N/A physical interaction ComPPI
MUC1 ATP6V0A1 25348397 N/A physical interaction ComPPI
MUC1 ATP11C 25348397 N/A physical interaction ComPPI
MUC1 TMEM59L 25348397 N/A physical interaction ComPPI
MUC1 TMEM63B 25348397 N/A physical interaction ComPPI
MUC1 MYADM 25348397 N/A physical interaction ComPPI
MUC1 CCDC115 25348397 N/A physical interaction ComPPI
MUC1 ACTBL2 25348397 N/A physical interaction ComPPI
ZAP70 MUC1 14525934 14766232 N/A experimental interaction detection HPRD
SIGLEC1 MUC1 10610356 14525934 N/A experimental interaction detection HPRD
LCK MUC1 14525934 14766232 N/A experimental interaction detection HPRD
GALNT1 MUC1 14525934 9295285 N/A experimental interaction detection HPRD
GALNT2 MUC1 12754287 12925576 14525934 27898060 9295285 9312074 N/A experimental interaction detection HPRD,OmniPath
OSGEP MUC1 10859271 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
GALNT10 MUC1 12417297 14525934 N/A experimental interaction detection HPRD
GALNT15 MUC1 14525934 15147861 27898060 N/A experimental interaction detection HPRD,OmniPath
MUC1 MUC1 21798038 24234451 physical association cross-linking study IntAct
SRC MUC1 11152665 11483589 14521915 15471854 21798038 22140559 27898060 7664271 stimulant N/A OmniPath
LCK MUC1 14766232 27898060 stimulant N/A OmniPath
LYN MUC1 12750561 27898060 N/A N/A OmniPath
EGFR MUC1 11152665 11278868 11483589 16983337 17889671 21258405 24658140 25402006 27898060 stimulant N/A OmniPath
MUC1 EGFR 11278868 11483589 16983337 17889671 21258405 24658140 25402006 27898060 N/A N/A OmniPath
PRKCD MUC1 11877440 27898060 stimulant N/A OmniPath
PDGFRB MUC1 14521915 15471854 16507569 17545600 18083107 27898060 N/A N/A OmniPath
IKBKG MUC1 18037881 27898060 N/A N/A OmniPath
ADAM17 MUC1 12441351 27898060 inhibition N/A OmniPath
ABL1 MUC1 14521915 16888623 20841568 27898060 stimulant N/A OmniPath
GSK3B MUC1 11152665 14521915 27898060 9819408 N/A N/A OmniPath
ZAP70 MUC1 14766232 27898060 stimulant N/A OmniPath
CSK MUC1 11152665 11483589 14521915 17545600 18083107 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008B471E MUC1 27087310 direct interaction,inhibition N/A NPInter

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