Gene Information gene info

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GENE：PLK3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PLK3
FullNmae polo like kinase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2154
EnsembleID ENSG00000173846
Uniprot Q9H4B4

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PLK3 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLK3 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLK3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLK3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLK3 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PLK3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PLK3 GO:0000082,GO:0000086,GO:0000122,GO:0000302,GO:0000776,GO:0000922,GO:0002039,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005737,GO:0005795,GO:0005813,GO:0005813,GO:0006468,GO:0006915,GO:0006970,GO:0006974,GO:0006974,GO:0006974,GO:0006977,GO:0007052,GO:0007113,GO:0009314,GO:0030425,GO:0031122,GO:0032465,GO:0032465,GO:0043025,GO:0043066,GO:0043491,GO:0044819,GO:0044819,GO:0051302,GO:0090166,GO:0090166,GO:0090316,GO:0106310,GO:1901796,GO:1904716,GO:2000777

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PLK3 hsa:1263 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
PLK3 hsa:1263 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
PLK3 hsa:1263 path:hsa05152 Tuberculosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PLK3 JUN 17804415 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PLK3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PLK3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PLK3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PLK3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PLK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PLK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PLK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PLK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PLK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PLK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PLK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PLK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PLK3 16581545 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 PLK3 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PLK3 ATF2 22135298 phosphorylation N/A PhosphoSite
PLK3 YWHAE 22135298 phosphorylation N/A PhosphoSite
PLK3 CHEK2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PLK3 TOP2A 22135298 phosphorylation N/A PhosphoSite
PLK3 PTEN 22135298 phosphorylation N/A PhosphoSite
PLK3 CALU 22135298 phosphorylation N/A PhosphoSite
PLK3 HSP90AB1 22135298 phosphorylation N/A PhosphoSite
PLK3 NPM1 22135298 phosphorylation N/A PhosphoSite
PLK3 CDC25C 22135298 phosphorylation N/A PhosphoSite
PLK3 JUN 22135298 phosphorylation N/A PhosphoSite
PLK3 TP53 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PLK3 CCNB1 22135298 phosphorylation N/A PhosphoSite
PLK3 CASP8 22135298 phosphorylation N/A PhosphoSite
PLK3 VRK1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PLK3 CDC25A 22135298 phosphorylation N/A PhosphoSite
PLK3 OCLN 22135298 phosphorylation N/A PhosphoSite
PLK3 SNCB 22135298 phosphorylation N/A PhosphoSite
PLK3 HIF1A 22135298 phosphorylation N/A PhosphoSite
PLK3 BCL2L1 22135298 phosphorylation N/A PhosphoSite
PLK3 SNCA 22135298 phosphorylation N/A PhosphoSite
VRK1 PLK3 25361965 interaction type N/A PTMCode2
MAPK1 PLK3 25361965 interaction type N/A PTMCode2
PLK3 MAPK1 25361965 interaction type N/A PTMCode2
CIB1 PLK3 25361965 interaction type N/A PTMCode2
PLK3 CIB1 25361965 interaction type N/A PTMCode2
TP53 PLK3 25361965 interaction type N/A PTMCode2
CHEK2 PLK3 25361965 interaction type N/A PTMCode2
MAP2K1 PLK3 25361965 interaction type N/A PTMCode2
PLK3 MAP2K1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PLK3 CIB1 10523297 11039900 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PLK3 CHEK2 10973490 11901158 12242661 12493754 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PLK3 MAP2K1 14525934 15021912 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PLK3 MAPK1 14525934 15021912 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PLK3 TRIP13 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PLK3 VRK1 14525934 19103756 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo,confocal microscopy ComPPI,HPRD,IntAct
PLK3 CDC25C 10557092 11333986 11551930 14525934 25348397 9278512 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PLK3 TP53 10673501 11551930 11709713 12242661 12548019 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PLK3 PTPRC 25348397 N/A physical interaction ComPPI
PLK3 PRNP 25348397 N/A physical interaction ComPPI
PLK3 PRNP 18482256 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,protein array,physical interaction,fluorescence microscopy ComPPI,IntAct
PLK3 AURKA 25348397 N/A physical interaction ComPPI
PLK3 BUB1B 15190214 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PLK3 SNCA 25348397 N/A physical interaction ComPPI
PLK3 SNCB 25348397 N/A physical interaction ComPPI
PLK3 CENPU 25348397 N/A physical interaction ComPPI
PLK3 POU2F1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PLK3 BCL2L1 25348397 N/A physical interaction ComPPI
PLK3 HIF1A 25348397 N/A physical interaction ComPPI
PLK3 LSM5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PLK3 RNF141 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PLK3 RAD52 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PLK3 PTEN 12297295 16107342 19629644 20940307 24047694 27898060 inhibition N/A OmniPath
PLK3 CDC25A 18167338 20348946 21376736 27898060 inhibition N/A OmniPath
PLK3 CHEK2 10973490 11901158 12242661 12493754 16481012 17918214 27898060 stimulant N/A OmniPath
PLK3 BCL2L1 21336504 21840391 27898060 stimulant N/A OmniPath
PLK3 CDC25C 10557092 11333986 11551930 12742231 14968113 15629715 20068231 27898060 9278512 9543386 stimulant N/A OmniPath
PLK3 ATF2 20068231 21098032 27898060 stimulant N/A OmniPath
TP53 PLK3 10673501 11551930 11709713 12242661 12548019 18431400 27898060 stimulant N/A OmniPath
PLK3 TP53 10673501 11447225 11551930 11709713 12242661 12548019 27898060 stimulant N/A OmniPath
PLK3 HIF1A 18519666 20889502 27898060 inhibition N/A OmniPath
PLK3 HSP90AB1 22824801 27898060 N/A N/A OmniPath
PLK3 SNCA 19889641 21849493 27898060 stimulant N/A OmniPath
PLK3 TOP2A 17081983 18062778 18669648 27898060 stimulant N/A OmniPath
JUN PLK3 17804415 27898060 N/A N/A OmniPath
PLK3 JUN 15302935 17804415 18650425 18669648 19413330 19690332 27898060 stimulant N/A OmniPath
PLK3 SNCB 19889641 21849493 27898060 stimulant N/A OmniPath
PLK3 YWHAE 22828320 27898060 N/A N/A OmniPath
PLK3 VRK1 17617371 19103756 20068231 27898060 stimulant N/A OmniPath

Visualization










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