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GENE：PFKFB1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PFKFB1
FullNmae 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8872
EnsembleID ENSG00000158571
Uniprot P16118

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PFKFB1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PFKFB1 GO:0003873,GO:0003873,GO:0004331,GO:0004331,GO:0005515,GO:0005524,GO:0005829,GO:0005829,GO:0006000,GO:0006003,GO:0006003,GO:0006094,GO:0006096,GO:0019900,GO:0031100,GO:0032868,GO:0033762,GO:0042594,GO:0042802,GO:0043540,GO:0043540,GO:0046835,GO:0051384,GO:0051591,GO:0070095,GO:1904539

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PFKFB1 hsa:5207 path:hsa00051 Fructose and mannose metabolism - Homo sapiens (human)
PFKFB1 hsa:5207 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PFKFB1 hsa:5207 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
PFKFB1 hsa:5207 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA2 PFKFB1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 PFKFB1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 PFKFB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PFKFB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A PFKFB1 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFIC PFKFB1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PRKCA PFKFB1 25348397 N/A physical interaction ComPPI
MAPK3 PFKFB1 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKACA PFKFB1 25348397 N/A physical interaction ComPPI
HNRNPL PFKFB1 25348397 N/A physical interaction ComPPI
AKT1 PFKFB1 25348397 N/A physical interaction ComPPI
GCK PFKFB1 11522786 24234451 25348397 N/A phage display,enzyme linked immunosorbent assay ComPPI,IntAct
PLEKHG4 PFKFB1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APP PFKFB1 25348397 N/A physical interaction ComPPI
PASK PFKFB1 21418524 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
PFKFB3 PFKFB1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PFKFB1 PFKFB4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NCOR1 PFKFB1 24234451 26120082 association chromatin immunoprecipitation assay IntAct
PFKFB1 NR1H2 24234451 26120082 association chromatin immunoprecipitation assay IntAct
PFKFB1 NR1H3 24234451 26120082 association chromatin immunoprecipitation assay IntAct
AR PFKFB1 17721441 27898060 stimulant N/A OmniPath

Visualization










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