GENE：RIMS1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | RIMS1 |
| FullNmae | regulating synaptic membrane exocytosis 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:17282 |
| EnsembleID | ENSG00000079841 |
| Uniprot | Q86UR5 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| RIMS1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| RIMS1 | GO:0003723,GO:0005515,GO:0005829,GO:0005886,GO:0006886,GO:0007601,GO:0010628,GO:0016079,GO:0017156,GO:0030154,GO:0030695,GO:0031267,GO:0042391,GO:0042734,GO:0042734,GO:0042734,GO:0042995,GO:0044325,GO:0045055,GO:0046872,GO:0046903,GO:0046928,GO:0048167,GO:0048786,GO:0048788,GO:0048791,GO:0050806,GO:0050896,GO:0060478,GO:0061025,GO:0065003,GO:0097151,GO:1903861,GO:2000300,GO:2000463 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| RIMS1 | hsa:22999 | path:hsa04721 | Synaptic vesicle cycle - Homo sapiens (human) |
| RIMS1 | hsa:22999 | path:hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | RIMS1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | RIMS1 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | RIMS1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | RIMS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | RIMS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | RIMS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | RIMS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | RIMS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | RIMS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | RIMS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | RIMS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | RIMS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | RIMS1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RAB10 | RIMS1 | 12578829 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| NCK1 | RIMS1 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| GRB2 | RIMS1 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| SMAD2 | RIMS1 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| HNRNPL | RIMS1 | 25348397 | N/A | physical interaction | ComPPI |
| SNAP25 | RIMS1 | 11438521 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SYT1 | RIMS1 | 11438520 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| RIMS1 | YWHAH | 12871946 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| RIMS1 | UNC13B | 11343654 11797009 12163476 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| RIMS1 | ERC1 | 12391317 14525934 25348397 27898060 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD,OmniPath |
| RIMS1 | ERC2 | 12163476 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| RIMS1 | RAB27A | 12578829 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| RIMS1 | CACNA1C | 11438519 25348397 27898060 | N/A | in vitro | ComPPI,OmniPath |
| RIMS1 | STX1A | 11438522 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| RIMS1 | LRRK1 | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RIMS1 | CAMK2A | 25348397 | N/A | physical interaction | ComPPI |
| RIMS1 | PDK1 | 25348397 | N/A | physical interaction | ComPPI |
| RIMS1 | ABL1 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| RIMS1 | FYN | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| MYH1 | RIMS1 | 25348397 | N/A | physical interaction | ComPPI |
| C1ORF94 | RIMS1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| RIMS1 | SYT1 | 11438518 11438520 27898060 | stimulant | N/A | OmniPath |
| PRKACA | RIMS1 | 14532002 27898060 | stimulant | N/A | OmniPath |
| CAMK2A | RIMS1 | 12871946 27898060 | stimulant | N/A | OmniPath |
| RIMS1 | YWHAH | 12871946 27898060 | stimulant | N/A | OmniPath |
| RIMS1 | RPH3A | 11431472 27898060 | stimulant | N/A | OmniPath |
| RIMS1 | UNC13B | 11343654 11797009 12163476 27898060 | stimulant | N/A | OmniPath |