Gene Information gene info

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GENE：SEC61B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SEC61B
FullNmae SEC61 translocon subunit beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16993
EnsembleID ENSG00000106803
Uniprot P60468

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SEC61B immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SEC61B GO:0003723,GO:0005515,GO:0005783,GO:0005784,GO:0005789,GO:0005829,GO:0006616,GO:0016020,GO:0016020,GO:0016020,GO:0030433,GO:0030970,GO:0031204,GO:0031205,GO:0043022,GO:0044322,GO:0048408

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SEC61B hsa:10952 path:hsa03060 Protein export - Homo sapiens (human)
SEC61B hsa:10952 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
SEC61B hsa:10952 path:hsa04145 Phagosome - Homo sapiens (human)
SEC61B hsa:10952 path:hsa05110 Vibrio cholerae infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SEC61B SEC61A2 19509052 26192618 interaction type N/A ACSN
SEC61G SEC61B 19509052 26192618 interaction type N/A ACSN
SEC61B SSR2 18724357 23180781 physical association anti tag coimmunoprecipitation InnateDB
CFTR SEC61B 23180781 9792704 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR SEC61B 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 SEC61B 20034404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 SEC61B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SEC61B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SEC61B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SEC61B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SEC61B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC SEC61B N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000005481D SEC61B 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
SEC61B SSR1 25361965 interaction type N/A PTMCode2
SSR1 SEC61B 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EXOC5 SEC61B 25348397 N/A physical interaction ComPPI
GET3 SEC61B 20516149 20676083 22505607 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SGTA SEC61B 25348397 N/A physical interaction ComPPI
UBL4A SEC61B 25348397 N/A physical interaction ComPPI
KEAP1 SEC61B 25348397 N/A physical interaction ComPPI
MYH7 SEC61B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SERP1 SEC61B 10601334 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
FBXW7 SEC61B 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CANX SEC61B 25348397 N/A physical interaction ComPPI
BAG6 SEC61B 25348397 N/A physical interaction ComPPI
BUB1 SEC61B 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MUTYH SEC61B 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SEC61B TRAM1 14525934 25348397 27898060 9512475 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
SEC61B SEC63 10799540 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SEC61B ARL6 10508919 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SEC61B SPC25 14525934 25348397 9585408 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SEC61B APOB 14525934 25348397 9565615 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SEC61B AMFR 25348397 N/A physical interaction ComPPI
SEC61B GET4 25348397 N/A physical interaction ComPPI
SEC61B BCAP31 18555783 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,ubiquitin reconstruction,physical interaction,fluorescence microscopy ComPPI,IntAct
SEC61B SEC61A1 25348397 N/A physical interaction ComPPI
SEC61B EGFR 19602593 20937808 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SEC61B EDEM1 25348397 N/A physical interaction ComPPI
SEC61B ATP13A2 22645275 24234451 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
SEC61B AGER 25348397 N/A physical interaction ComPPI
SEC61B ESR1 21182205 24234451 25348397 association cosedimentation through density gradient,physical interaction ComPPI,IntAct
SEC61B FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
SEC61B ITGA4 25348397 N/A physical interaction ComPPI
SEC61B ERLIN2 21343306 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SEC61B MED23 25348397 N/A physical interaction ComPPI
SEC61B CBR1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC61B MED12 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC61B TUBA1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC61B ARMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC61B LTN1 25348397 N/A physical interaction ComPPI
SEC61B NEMF 25348397 N/A physical interaction ComPPI
SEC61B SSR1 17380188 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC61B RPL6 25348397 N/A physical interaction ComPPI
SEC61B RPS9 25348397 N/A physical interaction ComPPI
SEC61B OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC61B ZNF131 25348397 N/A physical interaction ComPPI
SEC61B STING1 18724357 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC61B SSR2 18724357 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC61B VCAM1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
SEC61B AURKA 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SEC61B BMPR1A 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SEC61B CDKN2A 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SEC61B MCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SEC61B MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SEC61B HIF1AN 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
SEC61B RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
SEC61B SEC61A2 24234451 30021884 physical association cross-linking study IntAct
CFTR SEC61B 27898060 9792704 N/A N/A OmniPath

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