GENE:SPECC1L
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SPECC1L |
| FullNmae | sperm antigen with calponin homology and coiled-coil domains 1 like |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:29022 |
| EnsembleID | ENSG00000100014 |
| Uniprot | Q69YQ0 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SPECC1L | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SPECC1L | GO:0005515,GO:0005737,GO:0005815,GO:0005819,GO:0005921,GO:0007049,GO:0007155,GO:0015629,GO:0030036,GO:0031941,GO:0051301 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SPECC1L | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | SPECC1L | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | SPECC1L | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | SPECC1L | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | SPECC1L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SPECC1L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SPECC1L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | SPECC1L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | SPECC1L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SPECC1L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SPECC1L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SPECC1L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SPECC1L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | SPECC1L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | SPECC1L | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003ABC4 | SPECC1L | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000FC8EB | SPECC1L | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00004505E4 | SPECC1L | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000035CC3E | SPECC1L | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00005651EE | SPECC1L | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000003FD55 | SPECC1L | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000021D7C8 | SPECC1L | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001EFBE3 | SPECC1L | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C11BC | SPECC1L | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000251D0B | SPECC1L | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C403E | SPECC1L | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001ADE63 | SPECC1L | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000077DDE | SPECC1L | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CBC6D | SPECC1L | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000355E82 | SPECC1L | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EC1BE | SPECC1L | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| UBE2I | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| SNW1 | SPECC1L | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PPP1CB | SPECC1L | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| KEAP1 | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| VAV1 | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| GRB2 | SPECC1L | 12577067 24234451 25348397 | association | pull down | ComPPI,IntAct |
| JUN | SPECC1L | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PPP1R12A | SPECC1L | 24234451 25348397 28330616 | association | pull down | ComPPI,IntAct |
| FEZ1 | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| UBC | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| APC | SPECC1L | 20936779 24234451 25348397 | physical association | physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
| YBX1 | SPECC1L | 24234451 25348397 25497084 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| NFKBIA | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| IQGAP1 | SPECC1L | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CFTR | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| PDLIM7 | SPECC1L | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CDK2 | SPECC1L | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MDC1 | SPECC1L | 24234451 25348397 29656893 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| RIPK3 | SPECC1L | 14743216 24234451 25348397 | physical association | tandem affinity purification | ComPPI,IntAct |
| LPXN | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| DUSP22 | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| AP2M1 | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| ELOA | SPECC1L | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SYNPO | SPECC1L | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RCN1 | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| PAN2 | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| SPC25 | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| MYH9 | SPECC1L | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| KCTD17 | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| DBN1 | SPECC1L | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RPL15 | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| KSR1 | SPECC1L | 24234451 25348397 27086506 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| GLIS2 | SPECC1L | 17289029 24234451 25348397 | physical association | physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
| FBXO25 | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| CAPZA2 | SPECC1L | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| G3BP1 | SPECC1L | 25348397 | N/A | physical interaction | ComPPI |
| PLEKHA7 | SPECC1L | 24234451 25348397 28877994 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| SPECC1L | ATMIN | 25348397 | N/A | physical interaction | ComPPI |
