Gene Information gene info

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GENE：STX4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol STX4
FullNmae syntaxin 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11439
EnsembleID ENSG00000103496
Uniprot Q12846

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
STX4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
STX4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
STX4 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
STX4 GO:0000149,GO:0000322,GO:0002639,GO:0005484,GO:0005515,GO:0005615,GO:0005768,GO:0005773,GO:0005802,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0006836,GO:0006886,GO:0006887,GO:0006906,GO:0008284,GO:0009986,GO:0012505,GO:0016020,GO:0016230,GO:0016323,GO:0017157,GO:0030027,GO:0030335,GO:0030670,GO:0031201,GO:0031201,GO:0032589,GO:0034394,GO:0034599,GO:0035493,GO:0035749,GO:0035774,GO:0035774,GO:0036477,GO:0042581,GO:0043085,GO:0043197,GO:0043219,GO:0043311,GO:0045202,GO:0045785,GO:0048278,GO:0048284,GO:0048471,GO:0050921,GO:0060291,GO:0070062,GO:0071346,GO:0098794,GO:0098794,GO:0098978,GO:0098978,GO:1902041,GO:1903078,GO:1903575,GO:2000010

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
STX4 hsa:6810 path:hsa04130 SNARE interactions in vesicular transport - Homo sapiens (human)
STX4 hsa:6810 path:hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SNAP23 STX4 15753124 20634814 26192618 interaction type N/A ACSN
STX4 NAPA 16189514 23180781 physical association pull down InnateDB
STXBP5 STX4 23180781 25244094 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 STX4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 STX4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C STX4 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 STX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA STX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF STX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 STX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 STX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 STX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS STX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A STX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF STX4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000096022 STX4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000450F92 STX4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED STX4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 STX4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 STX4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 STX4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 STX4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075B538 STX4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000024A59E STX4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000365675 STX4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E STX4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 STX4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CBC6D STX4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 STX4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000759B6A STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027464B STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001DC1D3 STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000258D51 STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA STX4 23313552 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000600E6 STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 STX4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 STX4 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000AD002 STX4 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000006372A STX4 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000EBD4B STX4 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000355E82 STX4 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000041FA2C STX4 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SNAP29 STX4 25361965 interaction type N/A PTMCode2
STX4 SNAP29 25361965 interaction type N/A PTMCode2
RAB5A STX4 25361965 interaction type N/A PTMCode2
STX4 RAB5A 25361965 interaction type N/A PTMCode2
NAPA STX4 25361965 interaction type N/A PTMCode2
STX4 NAPA 25361965 interaction type N/A PTMCode2
STX4 LLGL1 25361965 interaction type N/A PTMCode2
LLGL1 STX4 25361965 interaction type N/A PTMCode2
STX4 STXBP6 25361965 interaction type N/A PTMCode2
STXBP6 STX4 25361965 interaction type N/A PTMCode2
STX4 SCRIB 25361965 interaction type N/A PTMCode2
SCRIB STX4 25361965 interaction type N/A PTMCode2
STX4 RAB4A 25361965 interaction type N/A PTMCode2
RAB4A STX4 25361965 interaction type N/A PTMCode2
STX4 STXBP3 25361965 interaction type N/A PTMCode2
STXBP3 STX4 25361965 interaction type N/A PTMCode2
STX4 STXBP1 25361965 interaction type N/A PTMCode2
STXBP1 STX4 25361965 interaction type N/A PTMCode2
STX4 TXLNA 25361965 interaction type N/A PTMCode2
TXLNA STX4 25361965 interaction type N/A PTMCode2
STX4 STXBP4 25361965 interaction type N/A PTMCode2
STXBP4 STX4 25361965 interaction type N/A PTMCode2
STX4 VAMP1 25361965 interaction type N/A PTMCode2
VAMP1 STX4 25361965 interaction type N/A PTMCode2
STX4 NSF 25361965 interaction type N/A PTMCode2
NSF STX4 25361965 interaction type N/A PTMCode2
RAB11A STX4 25361965 interaction type N/A PTMCode2
STX4 RAB11A 25361965 interaction type N/A PTMCode2
YKT6 STX4 25361965 interaction type N/A PTMCode2
STX4 YKT6 25361965 interaction type N/A PTMCode2
VAMP4 STX4 25361965 interaction type N/A PTMCode2
STX4 VAMP4 25361965 interaction type N/A PTMCode2
SNAP23 STX4 25361965 interaction type N/A PTMCode2
STX4 SNAP23 25361965 interaction type N/A PTMCode2
VAMP8 STX4 25361965 interaction type N/A PTMCode2
STX4 VAMP8 25361965 interaction type N/A PTMCode2
VAMP3 STX4 25361965 interaction type N/A PTMCode2
STX4 VAMP3 25361965 interaction type N/A PTMCode2
SNAP25 STX4 25361965 interaction type N/A PTMCode2
STX4 SNAP25 25361965 interaction type N/A PTMCode2
SYT7 STX4 25361965 interaction type N/A PTMCode2
STX4 SYT7 25361965 interaction type N/A PTMCode2
STXBP2 STX4 25361965 interaction type N/A PTMCode2
STX4 STXBP2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TXLNA STX4 12558796 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TXLNB STX4 14525934 15184072 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
NDUFB9 STX4 25348397 N/A physical interaction ComPPI
RAB4A STX4 11063739 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
TMEM199 STX4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC22A STX4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STX11 STX4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAMP5 STX4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SNAP29 STX4 25348397 N/A physical interaction ComPPI
VAMP2 STX4 10194441 10820264 12417022 12517971 14525934 24234451 25348397 25416956 27898060 8760387 8770861 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct,OmniPath
STX12 STX4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
EMD STX4 24234451 25348397 25910212 physical association two hybrid array,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
UBL4A STX4 25348397 N/A physical interaction ComPPI
LMNA STX4 25348397 N/A physical interaction ComPPI
ACTB STX4 12435603 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SLC7A1 STX4 25348397 N/A physical interaction ComPPI
SERP1 STX4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMA3 STX4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDH1 STX4 25348397 N/A physical interaction ComPPI
SNAP25 STX4 14525934 25348397 8760387 9168999 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
SNAP23 STX4 14525934 25348397 9168999 9815132 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
STXBP1 STX4 25348397 N/A physical interaction ComPPI
STXBP3 STX4 10194441 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SYT1 STX4 25348397 N/A physical interaction ComPPI
STX4 RAB5A 11884531 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
STX4 SYT4 10397765 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
STX4 NSF 14525934 25348397 27898060 8973549 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
STX4 SEPTIN5 11880646 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
STX4 VAMP8 10820264 12130530 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
STX4 RAB11A 12435603 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
STX4 STXBP6 25348397 N/A physical interaction,in vitro,in vivo ComPPI
STX4 TXLNG 25348397 N/A in vitro ComPPI
STX4 STXBP5 12832401 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
STX4 SYT7 14525934 25348397 7791877 N/A experimental interaction detection,in vitro ComPPI,HPRD
STX4 STXBP4 10394363 12855681 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
STX4 VAMP7 14525934 14993220 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
STX4 NAPA 14525934 16189514 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid pooling approach,two hybrid ComPPI,HPRD,IntAct
STX4 VAMP4 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
STX4 SCRIB 25348397 N/A in vivo ComPPI
STX4 DLG1 14525934 18793635 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
STX4 LLGL1 14525934 18793635 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
STX4 VAPB 25348397 N/A physical interaction ComPPI
STX4 VAMP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STX4 ITSN2 25348397 N/A physical interaction ComPPI
STX4 ANXA3 25348397 N/A physical interaction ComPPI
STX4 ABCC1 25348397 N/A physical interaction ComPPI
STX4 MRPL12 25348397 N/A physical interaction ComPPI
STX4 SLC25A10 25348397 N/A physical interaction ComPPI
STX4 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
STX4 STX3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STX4 STX5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STX4 STX7 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STX4 STX16 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STX4 GOSR2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STX4 STX6 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STX4 BET1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STX4 VTI1B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STX4 GIMAP5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STX4 NAPB 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STX4 CYBRD1 21516116 24234451 25348397 25416956 25910212 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
STX4 SNAP47 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
STX4 CCDC8 25348397 N/A physical interaction ComPPI
STX4 SCGN 25348397 N/A physical interaction ComPPI
STX4 TMEM171 25348397 N/A physical interaction ComPPI
STX4 PLPPR1 25348397 N/A physical interaction ComPPI
STX4 AAGAB 25348397 N/A physical interaction ComPPI
STX4 ASPH 25348397 N/A physical interaction ComPPI
STX4 TMEM30B 25348397 N/A physical interaction ComPPI
STX4 IPPK 25348397 N/A physical interaction ComPPI
STX4 TACR1 25348397 N/A physical interaction ComPPI
STX4 GPR141 25348397 N/A physical interaction ComPPI
STX4 DPAGT1 25348397 N/A physical interaction ComPPI
STX4 GPRC5B 25348397 N/A physical interaction ComPPI
STX4 COG5 25348397 N/A physical interaction ComPPI
STX4 SLC39A8 25348397 N/A physical interaction ComPPI
STX4 RNF11 25348397 N/A physical interaction ComPPI
STX4 SCAMP5 19234194 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
STX4 SEC22B 22153078 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX4 USE1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX4 TMEM203 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX4 FAXDC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX4 STX1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX4 ZFPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX4 TRAF3IP3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX4 STX1B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX4 SUMO1P1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX4 GPR152 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX4 SGPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX4 RNF4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
STX8 STX4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
VAMP3 STX4 10820264 12130530 14525934 16189514 24234451 25348397 25416956 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
STX4 STX4 24234451 25416956 physical association two hybrid array IntAct

Source Target Pmid Interactiontype Methods Database
URS00009AE35F STX4 27087310 direct interaction,inhibition N/A NPInter
URS00008BB2C8 STX4 27087310 direct interaction,inhibition N/A NPInter

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