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GENE：CDKN1B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CDKN1B
FullNmae cyclin dependent kinase inhibitor 1B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1785
EnsembleID ENSG00000111276
Uniprot P46527

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CDKN1B parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDKN1B mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CDKN1B GO:0000079,GO:0000082,GO:0000082,GO:0001890,GO:0001934,GO:0004860,GO:0004861,GO:0004861,GO:0004861,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005768,GO:0005829,GO:0006813,GO:0006977,GO:0007096,GO:0007219,GO:0007507,GO:0007605,GO:0008284,GO:0008285,GO:0008285,GO:0009410,GO:0009749,GO:0019901,GO:0019903,GO:0019914,GO:0030308,GO:0030332,GO:0030332,GO:0030334,GO:0030544,GO:0031116,GO:0031464,GO:0031625,GO:0032355,GO:0033673,GO:0042326,GO:0043200,GO:0043231,GO:0043434,GO:0044877,GO:0045732,GO:0045736,GO:0045736,GO:0045892,GO:0045930,GO:0046686,GO:0048102,GO:0048839,GO:0051087,GO:0051168,GO:0051179,GO:0051179,GO:0051726,GO:0051726,GO:0060090,GO:0060767,GO:0060770,GO:0071236,GO:0071285,GO:0071407,GO:0071456,GO:0090398,GO:0140678,GO:1902746,GO:1902806,GO:1904019,GO:1904030,GO:1904036,GO:1904706,GO:1905179,GO:1990757,GO:2000045

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CDKN1B hsa:1027 path:hsa01522 Endocrine resistance - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa04110 Cell cycle - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa04934 Cushing syndrome - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa05162 Measles - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa05200 Pathways in cancer - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa05215 Prostate cancer - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
CDKN1B hsa:1027 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDKN1B CDK2 12042314 15355997 23180781 9736735 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
CDKN1B SGK1 18570873 23180781 phosphorylation reaction in-gel kinase assay InnateDB
TSC2 CDKN1B 15355997 17470459 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDKN1B TSC2 15355997 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDKN1B TSC1 15355997 23180781 physical association anti tag coimmunoprecipitation InnateDB
SKP2 CDKN1B 12042314 15355997 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDKN1B YWHAQ 12042314 14504289 17470459 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDKN1B YWHAB 14504289 17470459 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDKN1B AKT1 12042314 14504289 16780593 23180781 phosphorylation reaction in-gel kinase assay,protein kinase assay InnateDB
YWHAH CDKN1B 12042314 14504289 23180781 physical association anti tag coimmunoprecipitation InnateDB
YWHAE CDKN1B 12042314 14504289 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDKN1B SFN 14504289 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 CDKN1B 15286281 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDKN1B GRB2 19523899 23180781 physical association isothermal titration calorimetry InnateDB
CDKN1B EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDKN1B CREB1 18160048 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDKN1B PIN1 19584057 23180781 physical association pull down InnateDB
PIN1 CDKN1B 19584057 23180781 physical association anti tag coimmunoprecipitation InnateDB
CCND1 CDKN1B 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR CDKN1B 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 CDKN1B 17681750 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ETS1 CDKN1B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SP1 CDKN1B 10072762 10542271 12907235 15064717 15951157 16518840 22415074 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
VDR CDKN1B 15064717 16518840 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 CDKN1B 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CDKN1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CDKN1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CDKN1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CDKN1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CDKN1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CDKN1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CDKN1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 CDKN1B 16331276 18025037 trascriptional regulation,stimulation inferred by curator TFlink
COPS5 CDKN1B 16951171 trascriptional regulation,stimulation inferred by curator TFlink
CUX1 CDKN1B 19332113 trascriptional regulation,stimulation inferred by curator TFlink
CUX1 CDKN1B 19332113 trascriptional regulation,stimulation inferred by curator TFlink
FHL2 CDKN1B 21377781 trascriptional regulation,stimulation inferred by curator TFlink
FOXO1 CDKN1B 21418583 trascriptional regulation,stimulation inferred by curator TFlink
HOXB7 CDKN1B 21474578 trascriptional regulation,stimulation inferred by curator TFlink
ING4 CDKN1B 18399550 20707719 trascriptional regulation,stimulation inferred by curator TFlink
IRF9 CDKN1B 15362048 trascriptional regulation,stimulation inferred by curator TFlink
KAT2B CDKN1B 19525977 trascriptional regulation,stimulation inferred by curator TFlink
KLF4 CDKN1B 22170594 trascriptional regulation,stimulation inferred by curator TFlink
MEN1 CDKN1B 10523037 trascriptional regulation,stimulation inferred by curator TFlink
MYCN CDKN1B 16618721 trascriptional regulation,stimulation inferred by curator TFlink
NFYA CDKN1B 15064717 trascriptional regulation,stimulation inferred by curator TFlink
NFYB CDKN1B 15064717 trascriptional regulation,stimulation inferred by curator TFlink
NFYC CDKN1B 15064717 trascriptional regulation,stimulation inferred by curator TFlink
NR4A1 CDKN1B 12842839 trascriptional regulation,stimulation inferred by curator TFlink
PROX1 CDKN1B 17069925 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CDKN1B 10542271 12907235 15064717 15951157 16518840 22415074 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 CDKN1B 18320073 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CDKN1B 15988033 trascriptional regulation,stimulation inferred by curator TFlink
UTF1 CDKN1B 23536577 trascriptional regulation,stimulation inferred by curator TFlink
VHL CDKN1B 10778984 trascriptional regulation,stimulation inferred by curator TFlink
ZNF300 CDKN1B 21777376 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A CDKN1B N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC CDKN1B N/A trascriptional regulation,stimulation inferred by curator TFlink
RARB CDKN1B N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004719AB CDKN1B 17627278 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000B59A2 CDKN1B 17627278 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000170CF4 CDKN1B 17569667 17627278 17721077 17914108 18155131 18246122 18413744 18417445 18521080 18708351 18834855 18983236 19088079 19107213 19150885 19153141 19424584 19749093 19859555 20018759 \N rna interference,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS0000153377 CDKN1B 17569667 17627278 17721077 17914108 18246122 18413744 18417445 18708351 18983236 19107213 19150885 19153141 19424584 19859555 20018759 rna interference,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS0000170CF4 CDKN1B 17569667 17627278 17721077 17914108 18155131 18246122 18413744 18417445 18521080 18708351 18834855 18927107 18983236 19088079 19107213 19150885 19153141 19424584 19730150 19749093 19859555 20012062 20018759 20371350 21572407 22012620 22743998 23446348 23592263 24586944 25416803 25436097 26153983 mrna cleavage,inhibition array technology,experimental interaction detection,nucleotide sequence identification,western blot,chromatin immunoprecipitation assay,northern blot,rna immunoprecipitation,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay miR2Disease,miRDeathDB,TarBase
URS0000153377 CDKN1B 17569667 17627278 17721077 17914108 18246122 18413744 18417445 18708351 18983236 19107213 19150885 19153141 19424584 19859555 20012062 20018759 20371350 21572407 22012620 22743998 23446348 23447020 23592263 24137356 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS00000B59A2 CDKN1B 17627278 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00004719AB CDKN1B 17627278 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000122ED0 CDKN1B 19088304 21572407 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS0000239117 CDKN1B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003BBF48 CDKN1B 21552422 21572407 23592263 25416803 27292025 27842905 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,clip,miRNA interference luciferase reporter assay TarBase
URS00001CC379 CDKN1B 23249749 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000012A1DD CDKN1B 20371350 24151081 24667864 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000101787 CDKN1B 20371350 24381057 25416803 mrna cleavage,inhibition western blot,clip,miRNA interference luciferase reporter assay TarBase
URS00003804D8 CDKN1B 21572407 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000045E0EC CDKN1B 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001EB9FC CDKN1B 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 CDKN1B 20371350 21572407 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000250A40 CDKN1B 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000031D186 CDKN1B 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000040828B CDKN1B 20371350 21572407 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 CDKN1B 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 CDKN1B 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 CDKN1B 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 CDKN1B 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E CDKN1B 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 CDKN1B 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 CDKN1B 20371350 21572407 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000308E4D CDKN1B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 CDKN1B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000052E1A6 CDKN1B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032FC1A CDKN1B 20371350 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 CDKN1B 20371350 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000009A9A2 CDKN1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001270D3 CDKN1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 CDKN1B 20371350 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000070B1D CDKN1B 20371350 22012620 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 CDKN1B 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 CDKN1B 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F CDKN1B 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 CDKN1B 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 CDKN1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA CDKN1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000000C73C CDKN1B 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000521626 CDKN1B 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005BB0FD CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000014F13C CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002394F5 CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001F5B39 CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002C7B2B CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006B702 CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075D1FC CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000A9FB9 CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000D0BB4 CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 CDKN1B 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000C36BD CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001FA076 CDKN1B 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 CDKN1B 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000472A9B CDKN1B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C28B2 CDKN1B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000016E46F CDKN1B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001C04A2 CDKN1B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002F8148 CDKN1B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 CDKN1B 21572407 25416803 25578966 mrna cleavage,inhibition array technology,experimental interaction detection,quantitative reverse transcription pcr,clip TarBase
URS0000527B00 CDKN1B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 CDKN1B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C CDKN1B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000C48FA CDKN1B 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000055BBE5 CDKN1B 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000171525 CDKN1B 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000018E72A CDKN1B 25416803 27059796 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS00004DA9DB CDKN1B 25416803 26278219 mrna cleavage,inhibition western blot TarBase

Source Target Pmid Interactiontype Methods Database
CAMK2A CDKN1B 22135298 phosphorylation N/A PhosphoSite
CSNK2A1 CDKN1B 22135298 phosphorylation N/A PhosphoSite
PRKAA1 CDKN1B 22135298 phosphorylation N/A PhosphoSite
CAMK1 CDKN1B 22135298 phosphorylation N/A PhosphoSite
YES1 CDKN1B 22135298 phosphorylation N/A PhosphoSite
MAPK3 CDKN1B 22135298 phosphorylation N/A PhosphoSite
CDK16 CDKN1B 22135298 phosphorylation N/A PhosphoSite
SRC CDKN1B 22135298 phosphorylation N/A PhosphoSite
PRKDC CDKN1B 22135298 phosphorylation N/A PhosphoSite
SGK1 CDKN1B 22135298 phosphorylation N/A PhosphoSite
ABL1 CDKN1B 22135298 phosphorylation N/A PhosphoSite
UHMK1 CDKN1B 22135298 phosphorylation N/A PhosphoSite
CDK2 CDKN1B 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK1 CDKN1B 22135298 phosphorylation N/A PhosphoSite
CDK6 CDKN1B 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
HIPK2 CDKN1B 22135298 phosphorylation N/A PhosphoSite
ATM CDKN1B 22135298 phosphorylation N/A PhosphoSite
PIM1 CDKN1B 22135298 phosphorylation N/A PhosphoSite
AKT1 CDKN1B 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
LYN CDKN1B 22135298 phosphorylation N/A PhosphoSite
RBX1 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B RBX1 25361965 interaction type N/A PTMCode2
CCND1 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CCND1 25361965 interaction type N/A PTMCode2
CDC34 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CDC34 25361965 interaction type N/A PTMCode2
CDKN1B YWHAQ 25361965 interaction type N/A PTMCode2
YWHAQ CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B YWHAH 25361965 interaction type N/A PTMCode2
YWHAH CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CCNA1 25361965 interaction type N/A PTMCode2
CCNA1 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CCNB1 25361965 interaction type N/A PTMCode2
CCNB1 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CDK4 25361965 interaction type N/A PTMCode2
CDK4 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CCND2 25361965 interaction type N/A PTMCode2
CCND2 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CCNE1 25361965 interaction type N/A PTMCode2
CCNE1 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B YWHAE 25361965 interaction type N/A PTMCode2
YWHAE CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CDK6 25361965 interaction type N/A PTMCode2
CDKN1B CDK2 25361965 interaction type N/A PTMCode2
CDKN1B AKT1 25361965 interaction type N/A PTMCode2
CDKN1B CCNA2 25361965 interaction type N/A PTMCode2
CCNA2 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B SKP2 25361965 interaction type N/A PTMCode2
SKP2 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B TSC1 25361965 interaction type N/A PTMCode2
TSC1 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B YWHAB 25361965 interaction type N/A PTMCode2
YWHAB CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B RPS27A 25361965 interaction type N/A PTMCode2
RPS27A CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B YWHAG 25361965 interaction type N/A PTMCode2
YWHAG CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B MCM7 25361965 interaction type N/A PTMCode2
MCM7 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CCNE2 25361965 interaction type N/A PTMCode2
CCNE2 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CKS1B 25361965 interaction type N/A PTMCode2
CKS1B CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CUL1 25361965 interaction type N/A PTMCode2
CUL1 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B RNF123 25361965 interaction type N/A PTMCode2
RNF123 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B SPDYA 25361965 interaction type N/A PTMCode2
SPDYA CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B GRB2 25361965 interaction type N/A PTMCode2
GRB2 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CASP8 25361965 interaction type N/A PTMCode2
CASP8 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CCND3 25361965 interaction type N/A PTMCode2
CCND3 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CUL4A 25361965 interaction type N/A PTMCode2
CUL4A CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B CDK3 25361965 interaction type N/A PTMCode2
CDK3 CDKN1B 25361965 interaction type N/A PTMCode2
XPO1 CDKN1B 25361965 interaction type N/A PTMCode2
CDKN1B XPO1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA2 CDKN1B 20551905 24234451 25348397 association pull down ComPPI,IntAct
PIN1 CDKN1B 25348397 N/A physical interaction ComPPI
UBE2I CDKN1B 25348397 N/A physical interaction ComPPI
TRIM21 CDKN1B 25348397 N/A physical interaction ComPPI
CKS1B CDKN1B 14525934 16209941 18805092 24234451 25348397 ubiquitination reaction,physical association experimental interaction detection,isothermal titration calorimetry,x-ray crystallography,physical interaction,enzymatic study ComPPI,HPRD,IntAct
YES1 CDKN1B 14525934 17254967 24234451 25348397 phosphorylation reaction experimental interaction detection,protein kinase assay,in vitro ComPPI,HPRD,IntAct
KPNA3 CDKN1B 14525934 15057270 24234451 25348397 association,physical association experimental interaction detection,pull down,biochemical,in vitro ComPPI,HPRD,IntAct
KPNA4 CDKN1B 25348397 N/A physical interaction ComPPI
HSPA8 CDKN1B 25348397 N/A physical interaction ComPPI
KPNA5 CDKN1B 14525934 15057270 22770219 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,biochemical,in vitro ComPPI,HPRD,IntAct
CDKN1A CDKN1B 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
CCND1 CDKN1B 10908655 14525934 17254966 24234451 25348397 26496610 7478582 9106657 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
NUTF2 CDKN1B 15057270 24234451 25348397 physical association biochemical ComPPI,IntAct
CDK6 CDKN1B 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
CDKN1B GRB2 11278754 14525934 25348397 N/A two hybrid,experimental interaction detection,isothermal titration calorimetry,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CDKN1B UCHL1 12082530 14525934 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,in vivo,two hybrid ComPPI,HPRD,IntAct
CDKN1B SKP2 10559916 12529174 14525934 16209941 18805092 22632967 24234451 25348397 ubiquitination reaction,physical association experimental interaction detection,isothermal titration calorimetry,pull down,x-ray crystallography,physical interaction,enzymatic study,in vitro,in vivo ComPPI,HPRD,IntAct
CDKN1B XPO1 11889117 12529437 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CDKN1B CCNE2 14525934 17254966 24234451 24358021 25348397 9840943 9858585 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,molecular sieving,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CDKN1B CCNA1 10022926 14525934 18692475 24234451 25348397 29997244 7478582 physical association bioluminescence resonance energy transfer,experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vivo,luminescence based mammalian interactome mapping ComPPI,HPRD,IntAct
CDKN1B NUP50 10811608 10891500 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
CDKN1B YWHAE 12042314 14525934 15057270 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
CDKN1B YWHAH 12042314 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CDKN1B CASP8 11420686 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CDKN1B COPS5 12082530 14525934 15480426 15688030 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,fluorescence microscopy,in vivo ComPPI,HPRD,IntAct
CDKN1B CDK2 12972555 14525934 15890360 16326706 17053782 17254966 17254967 17418410 21423803 23455922 23602568 24234451 24358021 25241761 25348397 25852190 26496610 9192873 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,surface plasmon resonance,physical interaction,footprinting,in vitro,tandem affinity purification,proximity ligation assay ComPPI,HPRD,IntAct
CDKN1B STMN1 14525934 15652749 21423803 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
CDKN1B TSC2 14525934 15355997 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CDKN1B CCND2 14525934 16189514 24234451 25348397 25910212 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
CDKN1B TRAF2 14525934 16189514 24234451 25241761 25348397 25910212 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,proximity ligation assay,two hybrid bait and prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
CDKN1B CDK5 14525934 15890360 23455922 23602568 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,surface plasmon resonance,physical interaction,footprinting,in vitro,tandem affinity purification,surface plasmon resonance array ComPPI,HPRD,IntAct
CDKN1B YWHAG 14525934 15057270 24234451 25348397 physical association experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
CDKN1B YWHAB 14525934 15057270 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CDKN1B CDK3 14525934 23602568 24234451 25348397 9811456 association experimental interaction detection,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
CDKN1B CUL4A 14525934 16467204 16537899 19056892 25348397 26613412 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
CDKN1B CDK4 10908655 14525934 16326706 17053782 19470470 23602568 24234451 25241761 25348397 9106657 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification,proximity ligation assay ComPPI,HPRD,IntAct
CDKN1B CCND3 10342870 14525934 16189514 24234451 25348397 physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo ComPPI,HPRD,IntAct
CDKN1B CCNA2 12501191 14525934 15890360 16209941 17254966 20596027 24234451 25348397 26496610 8684460 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,nuclear magnetic resonance,surface plasmon resonance,x-ray crystallography,physical interaction,footprinting,in vitro ComPPI,HPRD,IntAct
CDKN1B CCNB1 14525934 24234451 25348397 26496610 8756624 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
CDKN1B MCM7 14525934 16289477 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,two hybrid fragment pooling approach,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CDKN1B ARHGDIA 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN1B LYN 14525934 17254966 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
CDKN1B SRC 14525934 17254967 24234451 25348397 phosphorylation reaction experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
CDKN1B SPDYA 12972555 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN1B AKT1 12042314 12244301 14525934 24234451 25241761 25348397 phosphorylation reaction,physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CDKN1B CCNE1 17254966 17254967 19470470 24234451 25241761 25348397 8756624 association,physical association anti bait coimmunoprecipitation,pull down,physical interaction,proximity ligation assay ComPPI,IntAct
CDKN1B UBE2D2 18805092 24234451 25348397 ubiquitination reaction physical interaction,enzymatic study ComPPI,IntAct
CDKN1B UBE2B 25348397 N/A physical interaction ComPPI
CDKN1B RNF123 25348397 N/A physical interaction ComPPI
CDKN1B UBAC1 25348397 N/A physical interaction ComPPI
CDKN1B DDB1 25348397 N/A physical interaction ComPPI
CDKN1B UBE3A 25348397 N/A physical interaction ComPPI
CDKN1B RCHY1 25348397 N/A physical interaction ComPPI
CDKN1B KPNA1 25348397 N/A physical interaction ComPPI
CDKN1B YWHAZ 25348397 N/A physical interaction ComPPI
CDKN1B KAT2B 22547391 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CDKN1B H1-5 25348397 N/A physical interaction ComPPI
CDKN1B ELAVL1 25348397 N/A physical interaction ComPPI
CDKN1B CDK1 23602568 24234451 24358021 25348397 association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
CDKN1B JAK2 21423214 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDKN1B TSC1 25348397 N/A physical interaction ComPPI
CDKN1B SKP1 16209941 24234451 25348397 physical association isothermal titration calorimetry,x-ray crystallography,physical interaction ComPPI,IntAct
CDKN1B CUL1 11961546 18805092 24234451 25348397 ubiquitination reaction,physical association pull down,physical interaction,enzymatic study ComPPI,IntAct
CDKN1B H1-1 25348397 N/A physical interaction ComPPI
CDKN1B MAPK8 25348397 N/A physical interaction ComPPI
CDKN1B MAPK10 25348397 N/A physical interaction ComPPI
CDKN1B VCP 25348397 N/A physical interaction ComPPI
CDKN1B RPS6KA1 19470470 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,phosphorylation reaction,physical interaction,protein kinase assay ComPPI,IntAct
CDKN1B RHOA 19470470 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CDKN1B ABL1 14525934 17254966 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CDKN1B CAMK1 25348397 N/A physical interaction ComPPI
CDKN1B IRF1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDKN1B SGK1 25348397 N/A physical interaction ComPPI
CDKN1B TXNIP 25348397 N/A physical interaction ComPPI
CDKN1B UBC 25348397 N/A anti bait coimmunoprecipitation,physical interaction,physical interaction ComPPI
CDKN1B DCLRE1C 25348397 N/A physical interaction ComPPI
CDKN1B RBX1 18805092 24234451 25348397 ubiquitination reaction physical interaction,enzymatic study ComPPI,IntAct
CDKN1B COPS6 25348397 N/A physical interaction ComPPI
CDKN1B COP1 25348397 26254224 27898060 N/A physical interaction ComPPI,OmniPath
CDKN1B MYC 25348397 N/A physical interaction ComPPI
CDKN1B SIRT6 25348397 N/A physical interaction ComPPI
CDKN1B CKS2 25348397 N/A physical interaction ComPPI
CDKN1B CDK7 25348397 N/A physical interaction ComPPI
CDKN1B GNL3 25348397 N/A physical interaction ComPPI
CDKN1B SCML2 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
CDKN1B UBB 14525934 15469821 16123592 16209941 25348397 N/A anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD
CDKN1B RPS27A 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
CDKN1B UBA52 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
CDKN1B RAN 15057270 24234451 25348397 physical association biochemical ComPPI,IntAct
CDKN1B UBA1 18805092 24234451 25348397 ubiquitination reaction enzymatic study ComPPI,IntAct
CDKN1B PIM1 25348397 N/A anti bait coimmunoprecipitation ComPPI
CDKN1B CHUK 23602409 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
CDKN1B ARIH1 24076655 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CDKN1B THAP1 24234451 25348397 25910212 physical association two hybrid array,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
CDKN1B AURKA 24234451 24358021 25348397 physical association molecular sieving ComPPI,IntAct
CDKN1B CCNB2 24234451 24358021 25348397 physical association molecular sieving ComPPI,IntAct
YWHAQ CDKN1B 12042314 14525934 17470459 18281517 24234451 25348397 association,physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CDC34 CDKN1B 19123975 22748924 25348397 27898060 N/A physical interaction ComPPI,OmniPath
KPNA6 CDKN1B 22770219 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMB1 CDKN1B 25348397 N/A physical interaction ComPPI
RPL27A CDKN1B 24234451 30021884 physical association cross-linking study IntAct
SRC CDKN1B 10831586 12042314 14504289 15735731 16195327 17254967 27898060 inhibition N/A OmniPath
LYN CDKN1B 16195327 17254966 17254967 17908796 18454177 19204084 21423214 21423803 22276948 27898060 inhibition N/A OmniPath
CUL1 CDKN1B 10559916 12835716 22959436 27898060 inhibition,stimulant N/A OmniPath
TAF1 CDKN1B 18684994 27898060 stimulant N/A OmniPath
CDK6 CDKN1B 11360184 16160006 16782892 18615582 25241761 27898060 inhibition,stimulant N/A OmniPath
CDKN1B CCND3 10342870 10597239 11360184 16189514 16328436 16782892 23718855 26186194 27898060 8978686 9716181 inhibition N/A OmniPath
FOXO3 CDKN1B 14976264 15930121 27898060 inhibition,stimulant N/A OmniPath
PIN1 CDKN1B 19584057 27898060 N/A N/A OmniPath
CDK2 CDKN1B 10198259 10323868 10393546 10585280 11328857 11940657 12042314 12417722 12482975 12529437 12700233 12800980 12972555 14504289 15355997 15557281 15619620 15647383 15735731 15890360 15980415 16102793 16326706 16780593 16782892 17053782 17254966 17254967 17409098 17418410 17671428 18285702 18615582 18850315 19631451 22898779 23455922 23602568 25241761 25852190 26186194 26450989 26496610 27898060 8033213 8822197 8978686 9192873 9218599 9311993 9380407 9472014 9632134 9658399 9660939 9724724 9736735 inhibition,stimulant N/A OmniPath
CDKN1B CDK2 10198259 10323868 10393546 10585280 11328857 11940657 12042314 12417722 12529437 12800980 12972555 15355997 15557281 15619620 15647383 15890360 15980415 16102793 16326706 16782892 17053782 17254966 17254967 17409098 17418410 17671428 18285702 18615582 18850315 19631451 22898779 23455922 23602568 25241761 25852190 26186194 26450989 26496610 27898060 8033213 8822197 8978686 9192873 9218599 9311993 9380407 9472014 9632134 9658399 9660939 9724724 9736735 inhibition N/A OmniPath
PIM1 CDKN1B 18593906 27898060 inhibition N/A OmniPath
SKP2 CDKN1B 10559916 11463388 11565034 12042314 12140288 12529174 12813041 15075339 15355997 15469821 15735731 15980415 15998794 16209941 16774918 17409098 17873289 18239684 19533683 19686743 19852587 20160477 20160482 20663873 21237244 21503567 22310285 22524983 22632967 22959436 23589337 23910095 24085301 26450989 27898060 inhibition,stimulant N/A OmniPath
AKT1 CDKN1B 12042314 12244301 12244303 14504289 14967450 16209941 16288292 16780593 18570873 18593906 19377290 19829074 22119715 23400686 25241761 27898060 inhibition,stimulant N/A OmniPath
CDKN1B AKT1 12042314 12244301 14504289 16780593 25241761 27898060 N/A N/A OmniPath
STAT1 CDKN1B 17992189 27898060 stimulant N/A OmniPath
CDKN1B GRB2 11278754 19523899 27898060 N/A N/A OmniPath
MAPK3 CDKN1B 10931950 27898060 inhibition N/A OmniPath
ABL1 CDKN1B 16195327 17254966 18454177 27898060 inhibition N/A OmniPath
CDKN1B CDK1 15340381 18615582 23602568 26186194 27898060 inhibition N/A OmniPath
KMT2A CDKN1B 16997566 27898060 stimulant N/A OmniPath
CDKN1B TSC2 15355997 17470459 27898060 N/A N/A OmniPath
MAPK1 CDKN1B 10375532 10781063 10831586 10931950 11250155 11425869 12140288 12907657 15034923 16195327 16880511 17254966 17409098 19473963 21715330 23478441 25132260 26146988 27898060 inhibition,stimulant N/A OmniPath
RCHY1 CDKN1B 18006823 19445020 21236467 21728064 21959983 27898060 inhibition N/A OmniPath
SGK1 CDKN1B 12244301 12244302 12244303 15057270 18570873 27898060 inhibition N/A OmniPath
CSNK2A1 CDKN1B 15034923 27898060 N/A N/A OmniPath
JAG1 CDKN1B 16495313 27898060 stimulant N/A OmniPath
CCND1 CDKN1B 10908655 11360184 11940657 12036906 15695403 17053782 17254966 17699765 19556892 25416956 26496610 27898060 7478582 8033213 8978686 9106657 9311993 inhibition N/A OmniPath
HIPK2 CDKN1B 21715331 27898060 stimulant N/A OmniPath
COPS5 CDKN1B 10086358 11704659 12082530 15480426 15688030 16951171 17951406 18202760 18285702 18926707 22350412 24671224 27898060 inhibition N/A OmniPath
RPS6KA2 CDKN1B 12244301 12244302 12244303 14504289 27898060 N/A N/A OmniPath
AKT2 CDKN1B 12244303 27898060 inhibition N/A OmniPath
YWHAQ CDKN1B 12042314 14504289 17470459 18281517 27898060 inhibition N/A OmniPath
CDKN1B TSC1 15355997 27898060 N/A N/A OmniPath
YWHAE CDKN1B 12042314 14504289 15057270 27898060 inhibition N/A OmniPath
YWHAH CDKN1B 12042314 14504289 27898060 inhibition N/A OmniPath
PRKAA1 CDKN1B 17053782 18593906 19118035 27898060 N/A N/A OmniPath
CDC14A CDKN1B 12134069 27898060 N/A N/A OmniPath
UHMK1 CDKN1B 10831586 12042314 12093740 14504289 15302935 27898060 stimulant N/A OmniPath

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