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GENE：UPF3A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UPF3A
FullNmae UPF3A regulator of nonsense mediated mRNA decay
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20332
EnsembleID ENSG00000169062
Uniprot Q9H1J1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UPF3A immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
UPF3A GO:0001701,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0007283,GO:0035145,GO:0035145,GO:0042162,GO:0042162,GO:0043005,GO:0043231,GO:0045727,GO:0045727,GO:0051028,GO:2000623

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UPF3A hsa:65110 path:hsa03013 Nucleocytoplasmic transport - Homo sapiens (human)
UPF3A hsa:65110 path:hsa03015 mRNA surveillance pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 UPF3A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 UPF3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 UPF3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 UPF3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF UPF3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 UPF3A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE UPF3A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AF45F UPF3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000272A92 UPF3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000D6C3F UPF3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000009265 UPF3A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000058863C UPF3A 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
UPF3B UPF3A 25361965 interaction type N/A PTMCode2
UPF3A UPF3B 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPC UPF3A 11546873 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CEP43 UPF3A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HBD UPF3A 25348397 N/A physical interaction ComPPI
HBA1 UPF3A 25348397 N/A physical interaction ComPPI
CDK5RAP3 UPF3A 25348397 N/A physical interaction ComPPI
RBM8A UPF3A 11546873 11546874 14525934 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
GSK3B UPF3A 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
APOA1 UPF3A 25348397 N/A physical interaction ComPPI
SERPINA1 UPF3A 25348397 N/A physical interaction ComPPI
XPO1 UPF3A 25348397 N/A physical interaction ComPPI
SMG1 UPF3A 11544179 14525934 16452507 18256688 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
UPF2 UPF3A 11163187 19503078 20479275 24234451 25348397 association,physical association anti bait coimmunoprecipitation,pull down,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,IntAct
TOPORS UPF3A 25348397 N/A physical interaction ComPPI
EXOSC10 UPF3A 25348397 N/A physical interaction ComPPI
HTT UPF3A 25348397 N/A physical interaction,luminescence based mammalian interactome mapping ComPPI
SMG5 UPF3A 25348397 N/A anti tag coimmunoprecipitation ComPPI
UPF3B UPF3A 25348397 N/A pull down,physical interaction,physical interaction ComPPI
UPF1 UPF3A 11163187 12417715 14525934 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
XRN1 UPF3A 25348397 N/A physical interaction ComPPI
EXOSC4 UPF3A 25348397 N/A physical interaction ComPPI
RNF41 UPF3A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UPF3A IFITM2 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
UPF3A ALYREF 11546873 11546874 14525934 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
UPF3A PIGT 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
UPF3A DCP2 25348397 N/A physical interaction ComPPI
UPF3A EXOSC2 25348397 N/A physical interaction ComPPI
UPF3A PARN 25348397 N/A physical interaction ComPPI
UPF3A HBB 25348397 N/A physical interaction ComPPI
UPF3A RNPS1 11546874 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UPF3A NXF1 11546873 11546874 14525934 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
UPF3A APP 25348397 N/A physical interaction ComPPI
UPF3A WAPL 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UPF3A PHF8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UPF3A CASC3 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UPF3A AGGF1 25348397 N/A physical interaction ComPPI
UPF3A LONP1 25348397 N/A physical interaction ComPPI
UPF3A ALB 25348397 N/A physical interaction ComPPI
UPF3A HNRNPA1 11546873 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
UPF3A MAGOH 25348397 N/A anti tag coimmunoprecipitation ComPPI
SRRM1 UPF3A 11546874 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF4A3 UPF3A 25348397 N/A anti tag coimmunoprecipitation ComPPI
CA1 UPF3A 25348397 N/A physical interaction ComPPI

Visualization










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