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GENE：FOXM1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FOXM1
FullNmae forkhead box M1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3818
EnsembleID ENSG00000111206
Uniprot Q08050

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FOXM1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FOXM1 mitotic_cd 25411964 Effects of FOXM1 knockdown on ovarian cancer cell migration, invasion and mitotic catastrophe were also studied.  retulator signature
FOXM1 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
FOXM1 GO:0000086,GO:0000122,GO:0000785,GO:0000977,GO:0000977,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0006281,GO:0006357,GO:0006978,GO:0008284,GO:0019901,GO:0032873,GO:0042127,GO:0045892,GO:0045893,GO:0045944,GO:0045944,GO:0046578,GO:0051726,GO:2000377,GO:2000781

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FOXM1 hsa:2305 path:hsa04218 Cellular senescence - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FOXM1 CDK1 15024056 23180781 physical association anti tag coimmunoprecipitation InnateDB
FOXM1 CDK2 15024056 23180781 physical association anti tag coimmunoprecipitation InnateDB
FOXM1 CCNB1 15024056 23180781 physical association anti tag coimmunoprecipitation InnateDB
FOXM1 CDC25B 15024056 23180781 physical association anti tag coimmunoprecipitation InnateDB
FOXM1 RB1 15024056 23180781 physical association anti tag coimmunoprecipitation InnateDB
CREBBP FOXM1 15024056 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 FOXM1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
GATA2 FOXM1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A FOXM1 19097132 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC FOXM1 12695333 20658516 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MITF FOXM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATM FOXM1 21518729 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 FOXM1 21518729 trascriptional regulation,stimulation inferred by curator TFlink
FLI1 FOXM1 23365673 trascriptional regulation,stimulation inferred by curator TFlink
FOXO3 FOXM1 19276163 trascriptional regulation,stimulation inferred by curator TFlink
SP1 FOXM1 20372080 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 FOXM1 20372080 trascriptional regulation,stimulation inferred by curator TFlink
TP53 FOXM1 21518729 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000272A92 FOXM1 23010597 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00001C770D FOXM1 23762558 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000272A92 FOXM1 23010597 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000003ABC4 FOXM1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000021D7C8 FOXM1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D FOXM1 23762558 25416803 27415661 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004900F1 FOXM1 22900969 23576572 24055400 25416803 26617733 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002D0FC3 FOXM1 24999187 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS00002E177F FOXM1 25416803 27035590 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00003CF1AD FOXM1 25416803 27086911 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00001CC864 FOXM1 25416803 25445205 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS00002B7450 FOXM1 25416803 26588055 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000046CDA6 FOXM1 25416803 28225180 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000029D9F1 FOXM1 25416803 26722467 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 FOXM1 22135298 phosphorylation N/A PhosphoSite
CDK4 FOXM1 22135298 phosphorylation N/A PhosphoSite
PLK1 FOXM1 22135298 phosphorylation N/A PhosphoSite
CDK6 FOXM1 22135298 phosphorylation N/A PhosphoSite
STAT3 FOXM1 25361965 interaction type N/A PTMCode2
FOXM1 STAT3 25361965 interaction type N/A PTMCode2
CDH1 FOXM1 25361965 interaction type N/A PTMCode2
FOXM1 CDH1 25361965 interaction type N/A PTMCode2
CDK2 FOXM1 25361965 interaction type N/A PTMCode2
FOXM1 CDK2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I FOXM1 25348397 N/A physical interaction ComPPI
CDK6 FOXM1 25348397 N/A physical interaction,protein kinase assay ComPPI
LIN37 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
H2BC4 FOXM1 25348397 N/A physical interaction ComPPI
HSP90AB1 FOXM1 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
EZH2 FOXM1 25348397 N/A physical interaction ComPPI
SP1 FOXM1 25348397 N/A physical interaction ComPPI
FBXW7 FOXM1 25348397 N/A physical interaction ComPPI
RB1 FOXM1 25348397 N/A physical interaction ComPPI
CREBBP FOXM1 14525934 15024056 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SUMO1 FOXM1 25348397 N/A physical interaction ComPPI
SMAD3 FOXM1 25348397 N/A physical interaction ComPPI
FZR1 FOXM1 18573889 18758239 24362530 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MYBL2 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
GSK3B FOXM1 25348397 N/A physical interaction ComPPI
HERC5 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
HSP90AA1 FOXM1 25348397 N/A physical interaction ComPPI
TCF7L2 FOXM1 22014570 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,chromatin immunoprecipitation assay ComPPI,IntAct
AXIN1 FOXM1 25348397 N/A physical interaction ComPPI
GORASP2 FOXM1 23241949 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GSK3A FOXM1 25348397 N/A physical interaction ComPPI
PARD6B FOXM1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ECT2 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ORC2 FOXM1 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
QARS1 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
LIN9 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RNF8 FOXM1 25348397 N/A physical interaction ComPPI
RNF168 FOXM1 25348397 N/A physical interaction ComPPI
ANKRD12 FOXM1 22094256 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
CDK2 FOXM1 14525934 15024056 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CHEK2 FOXM1 25348397 N/A physical interaction ComPPI
CCNB1 FOXM1 25348397 N/A physical interaction ComPPI
CTNNB1 FOXM1 22014570 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,chromatin immunoprecipitation assay,confocal microscopy ComPPI,IntAct
BANP FOXM1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RBMX FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ZBTB33 FOXM1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
CDC37 FOXM1 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
IARS1 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
OS9 FOXM1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TRIM25 FOXM1 25348397 N/A physical interaction ComPPI
TERF1 FOXM1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
FOXO3 FOXM1 16809346 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CDC25B FOXM1 25348397 N/A physical interaction ComPPI
CDK4 FOXM1 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
SNRNP200 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FBXL2 FOXM1 24234451 25348397 26790640 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SMARCA5 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
KIF22 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
GTF3C4 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
TOP2A FOXM1 15965487 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PES1 FOXM1 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
CCNE1 FOXM1 16504183 24234451 25348397 phosphorylation reaction,physical association pull down,physical interaction,protein kinase assay ComPPI,IntAct
CDC27 FOXM1 25348397 N/A physical interaction ComPPI
DARS1 FOXM1 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
PRC1 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ZC3H11A FOXM1 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
USP5 FOXM1 25348397 N/A physical interaction ComPPI
SART1 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
DHX29 FOXM1 25348397 N/A physical interaction ComPPI
PRPF8 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MEN1 FOXM1 24234451 25348397 25609649 physical association pull down ComPPI,IntAct
DCAF1 FOXM1 25348397 N/A physical interaction ComPPI
LARS1 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
H2BC11 FOXM1 25348397 N/A physical interaction ComPPI
KIF18A FOXM1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
ZBTB3 FOXM1 25348397 N/A physical interaction ComPPI
SMC2 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ACAT1 FOXM1 25348397 N/A physical interaction ComPPI
CDK1 FOXM1 14525934 15024056 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
HSP90AA2P FOXM1 25348397 N/A physical interaction ComPPI
OTUB1 FOXM1 25348397 N/A physical interaction ComPPI
BCL6 FOXM1 25348397 N/A physical interaction ComPPI
BMS1 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FBXO31 FOXM1 25348397 N/A physical interaction ComPPI
PARS2 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
DNAJC9 FOXM1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXM1 RNASEH2B 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
FOXM1 LIN54 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXM1 LRWD1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXM1 TRMT1L 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXM1 DDX52 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXM1 DEPDC1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
FOXM1 IARS2 24234451 25348397 25609649 physical association pull down ComPPI,IntAct
FOXM1 STAT3 11861839 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
FOXM1 FOXM1 24234451 25609649 association tandem affinity purification IntAct
FOXM1 CDC25A 15689977 27898060 stimulant N/A OmniPath
PLK1 FOXM1 15531365 15654331 15689977 15817462 16314512 16809346 17173139 19160488 19737929 27898060 stimulant N/A OmniPath
FOXM1 PLK1 15531365 15654331 15689977 15817462 16314512 16809346 17173139 19160488 27898060 inhibition,stimulant N/A OmniPath
FOXM1 AURKB 15689977 15817462 16314512 17173139 27898060 inhibition,stimulant N/A OmniPath
CHEK2 FOXM1 17101782 27898060 stimulant N/A OmniPath
CDC25B FOXM1 15024056 27898060 N/A N/A OmniPath
FOXM1 CDC25B 12482952 15024056 15689977 16314512 20823107 27898060 stimulant N/A OmniPath
CDK6 FOXM1 22094256 23240008 26279295 27898060 N/A N/A OmniPath
CDK2 FOXM1 15024056 16504183 27898060 stimulant N/A OmniPath
FOXM1 CDC25C 16955137 20351091 27898060 stimulant N/A OmniPath
CREBBP FOXM1 15024056 27898060 N/A N/A OmniPath
CDK1 FOXM1 15024056 19160488 19737929 27898060 stimulant N/A OmniPath
FOXM1 MMP2 17404569 27898060 stimulant N/A OmniPath
CDK4 FOXM1 22094256 27898060 stimulant N/A OmniPath
FOXM1 CCNB1 10567581 11391529 11572993 11682060 15024056 15689977 15817462 27898060 stimulant N/A OmniPath
FOXM1 CENPF 15654331 15689977 27898060 stimulant N/A OmniPath

Visualization










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