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GENE：CASP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CASP1
FullNmae caspase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1499
EnsembleID ENSG00000137752
Uniprot P29466

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CASP1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP1 pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CASP1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP1 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CASP1 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. retulator signature
CASP1 autophagy 34925026 CASP1, SERPINA1, and CCL2 are autophagy-related hub genes of active UC. retulator signature
CASP1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CASP1 apoptosis 33999861 Related functional network identification suggests that CASP1 regulates apoptosis, immune and inflammatory response via pathways involving LYN, LCK, and the E2F family. retulator signature
CASP1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CASP1 GO:0002221,GO:0004175,GO:0004197,GO:0004197,GO:0005515,GO:0005730,GO:0005737,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0005874,GO:0005886,GO:0006508,GO:0006915,GO:0007165,GO:0007231,GO:0008656,GO:0016540,GO:0019900,GO:0032731,GO:0032731,GO:0032731,GO:0032731,GO:0032741,GO:0032991,GO:0032991,GO:0042742,GO:0042802,GO:0042802,GO:0042981,GO:0043123,GO:0043123,GO:0043280,GO:0046456,GO:0050700,GO:0050727,GO:0050727,GO:0050729,GO:0050729,GO:0050729,GO:0051604,GO:0051604,GO:0051607,GO:0061702,GO:0061702,GO:0070269,GO:0070269,GO:0071222,GO:0071222,GO:0071260,GO:0071310,GO:0071346,GO:0072557,GO:0072557,GO:0072558,GO:0072558,GO:0072559,GO:0072559,GO:0072559,GO:0089720,GO:0097169,GO:0097169,GO:0097169,GO:0097179,GO:0140447,GO:0140448,GO:0140970,GO:1903265

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CASP1 hsa:834 path:hsa04148 Efferocytosis - Homo sapiens (human)
CASP1 hsa:834 path:hsa04217 Necroptosis - Homo sapiens (human)
CASP1 hsa:834 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
CASP1 hsa:834 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
CASP1 hsa:834 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
CASP1 hsa:834 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
CASP1 hsa:834 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
CASP1 hsa:834 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
CASP1 hsa:834 path:hsa05131 Shigellosis - Homo sapiens (human)
CASP1 hsa:834 path:hsa05132 Salmonella infection - Homo sapiens (human)
CASP1 hsa:834 path:hsa05133 Pertussis - Homo sapiens (human)
CASP1 hsa:834 path:hsa05134 Legionellosis - Homo sapiens (human)
CASP1 hsa:834 path:hsa05135 Yersinia infection - Homo sapiens (human)
CASP1 hsa:834 path:hsa05164 Influenza A - Homo sapiens (human)
CASP1 hsa:834 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
CASP1 hsa:834 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CASP1 TIRAP 17360653 23180781 physical association anti tag coimmunoprecipitation,two hybrid,gst pull down InnateDB
PAK1 CASP1 15561713 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,protein kinase assay InnateDB
NOD2 CASP1 15107016 18511561 23180781 physical association anti tag coimmunoprecipitation InnateDB
NLRP1 CASP1 15107016 18511561 21252346 23180781 physical association anti tag coimmunoprecipitation InnateDB
PYCARD CASP1 11967258 14634131 16585594 19337385 21385879 23180781 24803432 physical association anti tag coimmunoprecipitation,two hybrid,gst pull down,pull down,fluorescence microscopy InnateDB
CASP1 CASP1 11051551 14634131 23180781 8700869 protein cleavage,physical association anti tag coimmunoprecipitation,protease assay,anti tag western blot InnateDB
RIPK2 CASP1 11051551 11536016 14634131 15039421 16585594 23180781 physical association anti tag coimmunoprecipitation InnateDB
NLRC4 CASP1 15107016 15882992 23180781 physical association anti tag coimmunoprecipitation InnateDB
NLRP3 CASP1 15030775 16037825 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
NLRP2 CASP1 15030775 23180781 23625868 physical association anti tag coimmunoprecipitation InnateDB
MEFV CASP1 16037825 16785446 17431422 18577712 23180781 cleavage reaction,physical association affinity chromatography technology,anti tag coimmunoprecipitation,pull down,protease assay InnateDB
IFT57 CASP1 17898872 23180781 physical association electrophoretic mobility shift assay InnateDB
NLRP10 CASP1 15096476 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP1 NLRP7 15817483 23180781 physical association anti tag coimmunoprecipitation InnateDB
EGFR CASP1 11226410 23180781 cleavage reaction protease assay InnateDB
CASP1 PLA2G4A 23180781 9875225 cleavage reaction protease assay InnateDB
CASP1 IL18 15326478 23180781 9121587 9334240 cleavage reaction,protein cleavage,physical association anti tag coimmunoprecipitation,protease assay InnateDB
IL1B CASP1 23180781 9121587 cleavage reaction protease assay InnateDB
GZMB CASP1 23180781 8700869 protein cleavage protease assay InnateDB
CASP3 CASP1 23180781 8700869 protein cleavage protease assay InnateDB
CARD8 CASP1 11821383 15030775 19337385 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
MAVS CASP1 20032188 23180781 cleavage reaction protease assay InnateDB
EP300 CASP1 15286281 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL37 CASP1 12096920 23180781 protein cleavage protease assay InnateDB
CASP1 ARHGDIA 19559631 23180781 protein cleavage protease assay InnateDB
CASP1 NLRP3 21385879 23180781 physical association anti tag coimmunoprecipitation InnateDB
EGR1 CASP1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP1 IFI16 21575908 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP1 DDX58 23180781 23592984 physical association anti tag coimmunoprecipitation InnateDB
IL18 CASP1 22270365 23180781 protein cleavage protease assay InnateDB
CASP1 IL33 19439663 23180781 protein cleavage protease assay InnateDB
CASP1 IL1B 19439663 23180781 protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
HTT CASP1 20005715 interaction type N/A PSP
NOD1 CASP1 20005715 interaction type N/A PSP
NOD2 CASP1 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
YBX1 CASP1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 CASP1 11278253 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SMARCA4 CASP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CASP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CASP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CASP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CASP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 CASP1 16103071 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003D8730 CASP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000306C70 CASP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000321A1A CASP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDA4 CASP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 CASP1 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
CASP14 CASP1 14525934 25348397 9792675 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LMNA CASP1 25348397 N/A in vitro,in vivo ComPPI
AIM2 CASP1 24234451 24630722 25348397 physical association electron microscopy,pull down ComPPI,IntAct
BCL2L1 CASP1 14525934 25348397 27898060 9027312 9435230 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
PAK1 CASP1 25348397 N/A in vitro,in vivo ComPPI
SYK CASP1 24234451 25348397 25605870 association anti tag coimmunoprecipitation ComPPI,IntAct
AR CASP1 14525934 25348397 9535906 N/A experimental interaction detection,in vitro ComPPI,HPRD
NFE2L2 CASP1 10510468 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
CEBPB CASP1 25348397 N/A physical interaction ComPPI
GAB1 CASP1 25348397 N/A physical interaction ComPPI
TFAP2A CASP1 11438643 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP1 CAST 14525934 25348397 9705209 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP1 CDK11A 25348397 N/A in vitro,in vivo ComPPI
CASP1 CDK11B 25348397 N/A in vitro ComPPI
CASP1 NLRP1 14525934 17418785 18511561 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,physical interaction,in vivo ComPPI,HPRD,IntAct
CASP1 IL1A 14525934 18329368 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
CASP1 FGF2 14525934 18329368 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
CASP1 EGFR 11226410 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP1 HTT 14525934 25348397 9535906 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP1 PSEN1 10069390 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP1 IL1B 14525934 1919001 19439663 24234451 25348397 7797510 protein cleavage experimental interaction detection,physical interaction,biochemical,protease assay,in vitro,in vivo,protein cleavage ComPPI,HPRD,IntAct
CASP1 MAPT 25348397 N/A in vitro,in vivo ComPPI
CASP1 PARP1 14525934 25348397 7642516 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP1 BCAP31 14525934 25348397 9334338 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP1 PSEN2 10069390 14525934 25348397 9219695 9990034 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP1 IL18 14525934 25348397 9334240 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP1 NEDD4 14525934 25348397 9593687 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP1 PRKN 12692130 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP1 RIPK2 14525934 24234451 25348397 9705938 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CASP1 NOD1 10329646 12459189 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP1 NLRC4 11374873 11390368 11472070 14525934 17418785 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CASP1 PYCARD 11967258 12019269 12191486 14525934 24234451 24630722 25348397 25605870 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,electron microscopy,experimental interaction detection,fluorescence polarization spectroscopy,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CASP1 ATXN3 14525934 25348397 9535906 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP1 CARD8 25348397 N/A in vitro,in vivo ComPPI
CASP1 CARD16 11432859 11536016 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CASP1 CARD17 14525934 15383541 24234451 25348397 27043298 physical association transmission electron microscopy,experimental interaction detection,molecular sieving,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
CASP1 PLA2G4A 14525934 25348397 9875225 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP1 NOD2 18511561 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,molecular sieving,physical interaction ComPPI,IntAct
CASP1 XK 25348397 N/A physical interaction ComPPI
CASP1 IL37 25348397 N/A physical interaction ComPPI
CASP1 CASP10 25348397 N/A physical interaction ComPPI
CASP1 CASP8 25348397 N/A physical interaction ComPPI
CASP1 TIRAP 17360653 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct
CASP1 BIRC3 25348397 N/A physical interaction ComPPI
CASP1 TRAF2 25348397 N/A physical interaction ComPPI
CASP1 IL33 25348397 N/A physical interaction,protease assay,protein cleavage ComPPI
CASP1 PLA2G4B 25348397 N/A physical interaction ComPPI
CASP1 VAC14 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CASP1 KIF3A 25348397 N/A physical interaction ComPPI
CASP1 KIF11 25348397 N/A physical interaction ComPPI
CASP1 ARID4B 25348397 N/A physical interaction ComPPI
CASP1 PI4KB 25348397 N/A physical interaction ComPPI
CASP1 FMN2 25348397 N/A physical interaction ComPPI
CASP1 IFI16 25348397 N/A physical interaction ComPPI
CASP1 BRCA1 25348397 N/A physical interaction ComPPI
CASP1 PLCL2 25348397 N/A physical interaction ComPPI
CASP1 MEFV 16785446 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CASP1 CARD18 24234451 25348397 27043298 N/A transmission electron microscopy,molecular sieving,pull down,physical interaction ComPPI,IntAct
CASP1 ATG16L1 24234451 24553140 25348397 protein cleavage protease assay ComPPI,IntAct
SERPINB9 CASP1 25348397 N/A physical interaction ComPPI
CASP1 ATN1 14525934 9535906 N/A experimental interaction detection HPRD
CASP1 CASP1 12459189 14525934 24234451 24630722 27043298 7721861 9190289 N/A experimental interaction detection,fluorescence polarization spectroscopy,electron tomography HPRD,IntAct
CASP1 BID 11085743 14525934 9727491 N/A experimental interaction detection HPRD
CASP1 TP53 11278253 24234451 physical association electrophoretic mobility shift assay IntAct
EGFR CASP1 11226410 27898060 N/A N/A OmniPath
CASP1 EGFR 11226410 27898060 N/A N/A OmniPath
CASP4 CASP1 12843244 27898060 9039262 9491891 stimulant N/A OmniPath
CASP1 NOD2 15107016 18511561 27898060 N/A N/A OmniPath
NOD2 CASP1 15107016 18511561 27898060 N/A N/A OmniPath
CASP1 NLRP1 11051551 11432859 11536016 12191486 15107016 15383541 17418785 18511561 21252346 27898060 inhibition N/A OmniPath
NLRP1 CASP1 11051551 11432859 11536016 12191486 15107016 15383541 17418785 18511561 21252346 27898060 stimulant N/A OmniPath
CASP1 RIPK2 10329646 11051551 11536016 12459189 14634131 15039421 16585594 27898060 9705938 N/A N/A OmniPath
CASP1 GAPDH 17959595 27898060 inhibition N/A OmniPath
CASP1 PYCARD 11051551 11432859 11536016 11967258 12019269 12191486 14634131 15383541 16585594 19337385 21385879 24630722 24803432 27898060 inhibition N/A OmniPath
PYCARD CASP1 11967258 12019269 12191486 14634131 16585594 19337385 21385879 24630722 24803432 27898060 stimulant N/A OmniPath
GZMB CASP1 27898060 8700869 N/A N/A OmniPath
CASP1 LMNA 11953316 27898060 8978814 N/A N/A OmniPath
CASP1 NLRP3 11821383 15030775 15190255 16037825 16407888 17382568 17470531 21385879 27898060 N/A N/A OmniPath
CASP1 CASP7 18667412 27898060 stimulant N/A OmniPath
CASP1 CASP3 27898060 8700869 stimulant N/A OmniPath
CASP1 BID 11085743 27898060 9727491 N/A N/A OmniPath
CASP1 MAVS 20032188 27898060 N/A N/A OmniPath
COP1 CASP1 11051551 11432859 11536016 15383541 27898060 inhibition N/A OmniPath
CASP1 SREBF2 16990137 27898060 stimulant N/A OmniPath
CASP1 ENO1 17959595 27898060 inhibition N/A OmniPath
CASP1 IL33 16286016 19439663 27898060 stimulant N/A OmniPath
CASP12 CASP1 16625199 27898060 inhibition N/A OmniPath
STAT1 CASP1 17085014 17339457 27898060 stimulant N/A OmniPath
CASP1 NEDD4 27898060 9593687 N/A N/A OmniPath
CASP1 CARD8 11051551 11432859 11536016 11821383 15030775 15383541 19337385 27898060 inhibition N/A OmniPath
CARD8 CASP1 11821383 15030775 19337385 27898060 inhibition N/A OmniPath
CASP1 TPI1 17959595 27898060 inhibition N/A OmniPath
TP53 CASP1 18431400 27898060 stimulant N/A OmniPath
CASP1 IL1A 18329368 27898060 stimulant N/A OmniPath
CASP1 CASP5 11051551 11432859 11536016 15383541 27898060 inhibition N/A OmniPath
CASP1 ALDOA 17959595 27898060 inhibition N/A OmniPath
CASP1 IL1B 17039247 1919001 19439663 27898060 7797510 8999548 9121587 inhibition,stimulant N/A OmniPath
PAK1 CASP1 15561713 27898060 stimulant N/A OmniPath
CASP1 IL37 12096920 27898060 stimulant N/A OmniPath
DDX58 CASP1 23592984 27898060 N/A N/A OmniPath
CARD18 CASP1 11051551 11432859 11536016 15383541 27898060 inhibition N/A OmniPath
CASP1 NLRC4 11051551 11374873 11390368 11432859 11472070 11536016 15107016 15190255 15383541 15882992 17382568 17418785 17470531 27898060 inhibition,stimulant N/A OmniPath
NLRC4 CASP1 11051551 11374873 11390368 11432859 11472070 11536016 15107016 15190255 15383541 15882992 17382568 17418785 17470531 27898060 N/A N/A OmniPath
CASP1 PSEN1 10069390 27898060 N/A N/A OmniPath
SERPINB9 CASP1 10477277 27898060 inhibition N/A OmniPath
CASP1 PARP1 27898060 7642516 N/A N/A OmniPath
CASP1 IL18 15326478 17039247 22270365 27898060 9121587 9334240 stimulant N/A OmniPath
IL18 CASP1 15326478 22270365 27898060 9121587 9334240 N/A N/A OmniPath
CASP1 FGF2 18329368 27898060 stimulant N/A OmniPath
CARD16 CASP1 11432859 11536016 27898060 inhibition N/A OmniPath
TIRAP CASP1 17360653 27898060 N/A N/A OmniPath
CASP1 IFI16 21575908 27898060 N/A N/A OmniPath
CASP1 ARHGDIA 19559631 27898060 N/A N/A OmniPath
NLRP10 CASP1 15096476 27898060 N/A N/A OmniPath
CASP1 PSEN2 10069390 27898060 9219695 9990034 N/A N/A OmniPath
PLA2G4A CASP1 27898060 9875225 N/A N/A OmniPath
PYDC1 CASP1 12656673 27898060 inhibition N/A OmniPath
MEFV CASP1 16037825 16785446 17431422 18577712 27898060 N/A N/A OmniPath
CASP1 MEFV 16037825 16785446 17431422 18577712 27898060 stimulant N/A OmniPath
CASP1 TRIM16L 16575408 27898060 N/A N/A OmniPath
CASP1 NLRP2 11051551 11432859 11536016 15030775 15190255 15383541 15456791 17382568 23625868 27898060 inhibition N/A OmniPath
CARD17 CASP1 11051551 11432859 11536016 15383541 27898060 inhibition N/A OmniPath

Visualization










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