Gene Information gene info

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GENE：IFNA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IFNA1
FullNmae interferon alpha 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5417
EnsembleID ENSG00000197919
Uniprot P01562

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IFNA1 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. retulator signature
IFNA1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IFNA1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IFNA1 GO:0002250,GO:0002286,GO:0002323,GO:0005125,GO:0005132,GO:0005515,GO:0005576,GO:0005615,GO:0006959,GO:0019221,GO:0030183,GO:0033141,GO:0042100,GO:0043330,GO:0051607,GO:0060337,GO:0098586

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IFNA1 hsa:3439 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa04217 Necroptosis - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05152 Tuberculosis - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05160 Hepatitis C - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05161 Hepatitis B - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05162 Measles - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05164 Influenza A - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05320 Autoimmune thyroid disease - Homo sapiens (human)
IFNA1 hsa:3439 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IFNA1 CR2 19164292 23180781 physical association solid phase assay InnateDB
IRF5 IFNA1 11303025 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
IFNA1 IRF3 11222729 11303025 11473119 14668346 19349300 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,pull down InnateDB
IRF7 IFNA1 10938111 11473119 14668346 19349300 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility shift assay InnateDB
IRF1 IFNA1 11473119 12077266 23180781 physical association affinity chromatography technology,electrophoretic mobility supershift assay InnateDB
BRCA1 IFNA1 17374731 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNA1 STAT1 17374731 23180781 physical association anti tag coimmunoprecipitation InnateDB
CREBBP IFNA1 19349300 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 IFNA1 19349300 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNA1 IFNAR1 23331499 8181059 stimulation N/A SignaLink,SignaLink
IFNA1 IFNAR2 23331499 8181059 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
YBX1 IFNA1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF IFNA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 IFNA1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC IFNA1 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F6E49 IFNA1 25416803 26580839 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
IFNAR1 IFNA1 25361965 interaction type N/A PTMCode2
IFNA1 IFNAR1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ISG15 IFNA1 25348397 N/A physical interaction ComPPI
IFNAR1 IFNA1 14525934 25348397 7932753 N/A experimental interaction detection,in vitro ComPPI,HPRD
UBQLN2 IFNA1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TOX4 IFNA1 25348397 N/A physical interaction ComPPI
CR2 IFNA1 14525934 1849076 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IFNA1 IRF9 14525934 25348397 8454630 N/A experimental interaction detection,in vitro ComPPI,HPRD
IFNA1 IL2 14525934 25348397 3262520 N/A experimental interaction detection,in vitro ComPPI,HPRD
IFNA1 IFNA5 25348397 N/A physical interaction ComPPI
IFNA1 IFNA8 25348397 N/A physical interaction ComPPI
IFNA1 IFNA21 25348397 N/A physical interaction ComPPI
IFNA1 IFNA6 25348397 N/A physical interaction ComPPI
IFNA1 IFNA17 25348397 N/A physical interaction ComPPI
IFNA1 IFNA14 25348397 N/A physical interaction ComPPI
IFNA1 HCCS 25348397 N/A physical interaction ComPPI
IFNA1 ZNF586 25348397 N/A physical interaction ComPPI
IFNA1 IFNAR2 25348397 N/A physical interaction,biochemical ComPPI
IFNA4 IFNA1 25348397 N/A physical interaction ComPPI
IFNA1 IFNAR1 11698684 21856167 27898060 7932753 8181059 stimulant N/A OmniPath
IFNA1 CR2 1849076 19164292 27898060 N/A N/A OmniPath
CR2 IFNA1 1849076 19164292 27898060 N/A N/A OmniPath
IFNA1 IFNAR2 10395669 11278538 11698684 21856167 27898060 8181059 stimulant N/A OmniPath

Visualization










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