Gene Information gene info

GENE:IL1R1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL1R1
FullNmae interleukin 1 receptor type 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5993
EnsembleID ENSG00000115594
Uniprot P14778

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL1R1 pyroptosis 35990672 As a result, CASP4, IGSF6 and IL1R1 were identified as the potential diagnostic and therapeutic targets for SCI by computational analysis, which were enriched in NF-κB and IL6-JAK-STATA3 signaling pathways. In the injured spinal cord, these three signatures were up-regulated and closely correlated with NLRP3 inflammasome formation and gasdermin D (GSDMD) -induced pyroptosis. retulator signature
IL1R1 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. retulator signature
IL1R1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL1R1 GO:0002020,GO:0004888,GO:0004908,GO:0004908,GO:0004909,GO:0005161,GO:0005515,GO:0005576,GO:0005886,GO:0005886,GO:0006954,GO:0006955,GO:0007166,GO:0009897,GO:0016020,GO:0019966,GO:0032729,GO:0050135,GO:0050727,GO:0061809,GO:0070498,GO:0070498,GO:0070555,GO:2000391,GO:2000556,GO:2000661

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL1R1 hsa:3554 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
IL1R1 hsa:3554 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL1R1 hsa:3554 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
IL1R1 hsa:3554 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
IL1R1 hsa:3554 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
IL1R1 hsa:3554 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
IL1R1 hsa:3554 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
IL1R1 hsa:3554 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
IL1R1 hsa:3554 path:hsa05131 Shigellosis - Homo sapiens (human)
IL1R1 hsa:3554 path:hsa05146 Amoebiasis - Homo sapiens (human)
IL1R1 hsa:3554 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
IL1R1 hsa:3554 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
IL1R1 hsa:3554 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL1R1 IL1RAP 11274345 12620219 12682231 14660645 15866876 16878026 17704786 17942936 18977329 19104081 19161412 23180781 23202296 23681101 23811849 24727385 26192618 9371760 9430229 association,physical association anti tag coimmunoprecipitation ACSN,InnateDB
IRAK4 IL1R1 11274345 12609980 12620219 12682231 14660645 16878026 17704786 18977329 19161412 23180781 23681101 23811849 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
MYD88 IL1R1 11274345 12609980 12620219 12659850 12682231 12738796 14660645 15125833 15905496 16252010 16286016 16354686 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 19940113 21614932 23070005 23180781 23681101 23811849 26192618 interaction type,physical association anti tag coimmunoprecipitation,gst pull down ACSN,InnateDB
IL1R1 IRAK1 11274345 12242293 12609980 12620219 12682231 12738796 14625308 14660645 15125833 15866876 15905496 16252010 16286016 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23180781 23331499 23681101 23811849 26192618 9374458 9430229 interaction type,stimulation,physical association anti tag coimmunoprecipitation ACSN,InnateDB,SignaLink
TRAF6 IL1R1 11274345 12242293 12609980 12620219 12738796 14660645 15125833 16252010 16286016 16354686 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23180781 23681101 23811849 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
IL1R1 MAP2K6 11274345 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26192618 interaction type N/A ACSN
IRAK2 IL1R1 12659850 23180781 9374458 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
TMED7 IL1R1 12721283 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL1R1 MYD88 15866876 23180781 9430229 physical association anti tag coimmunoprecipitation InnateDB
IL1RAP IL1R1 12530978 15044087 23180781 23331499 9371760 stimulation,physical association anti tag coimmunoprecipitation InnateDB,SignaLink
AKT1 IL1R1 12906710 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL1R1 SIGIRR 15866876 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL1R1 TRAF6 15866876 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAC1 IL1R1 16354686 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL1R1 IL1RN 23180781 8142597 physical association chromatography technology InnateDB
IL1R1 IL1B 23180781 8142597 physical association chromatography technology InnateDB
IL1R1 IL1A 23180781 8142597 physical association chromatography technology InnateDB
SIGIRR IL1R1 15866876 23180781 physical association anti tag coimmunoprecipitation InnateDB
FREM1 IL1R1 19940113 23180781 physical association anti tag coimmunoprecipitation InnateDB
EGR1 IL1R1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
TBX21 IL1R1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 IL1R1 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
IL1R1 IRAK4 15905496 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL1R1 IL1R1 10217414 10854325 14625308 26467481 interaction type,bind,up-regulates activity N/A Signor
IL1B IL1R1 23331499 9062193 stimulation N/A SignaLink,SignaLink
IL1R1 IRAK2 23331499 9374458 stimulation N/A SignaLink
IL1A IL1R1 23331499 2946959 9565970 stimulation N/A SignaLink
IL1R1 PIK3R1 23331499 9360994 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
PIK3R1 IL1R1 10373529 18988627 20005715 21071413 9360994 interaction type N/A PSP,SignaLink
TOLLIP IL1R1 10854325 17113392 20005715 21071413 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
ESR1 IL1R1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 IL1R1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 IL1R1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 IL1R1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 IL1R1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 IL1R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL1R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL1R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IL1R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IL1R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 IL1R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IL1R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 IL1R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 IL1R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 IL1R1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 IL1R1 15972639 trascriptional regulation,stimulation inferred by curator TFlink
STAT6 IL1R1 8757327 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 IL1R1 N/A trascriptional regulation,stimulation inferred by curator TFlink
RELA IL1R1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F4AC3 IL1R1 16822819 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 IL1R1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 IL1R1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000236310 IL1R1 25416803 28389653 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
IL1R1 IL1A 25361965 interaction type N/A PTMCode2
IL1A IL1R1 25361965 interaction type N/A PTMCode2
IL1R1 IL1B 25361965 interaction type N/A PTMCode2
IL1B IL1R1 25361965 interaction type N/A PTMCode2
IL1R1 PIK3R1 25361965 interaction type N/A PTMCode2
PIK3R1 IL1R1 25361965 interaction type N/A PTMCode2
IL1R1 TOLLIP 25361965 interaction type N/A PTMCode2
TOLLIP IL1R1 25361965 interaction type N/A PTMCode2
IL1R1 TRAF6 25361965 interaction type N/A PTMCode2
TRAF6 IL1R1 25361965 interaction type N/A PTMCode2
IL1R1 IRAK1 25361965 interaction type N/A PTMCode2
IRAK1 IL1R1 25361965 interaction type N/A PTMCode2
IL1R1 MYD88 25361965 interaction type N/A PTMCode2
MYD88 IL1R1 25361965 interaction type N/A PTMCode2
IL1RAP IL1R1 25361965 interaction type N/A PTMCode2
IL1R1 IL1RAP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TRAF6 IL1R1 16286467 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PIK3R1 IL1R1 10373529 14525934 25348397 9360994 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PDGFRB IL1R1 16477012 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
IL1RAP IL1R1 14525934 20802483 22426547 24234451 25348397 9371760 physical association experimental interaction detection,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
IRAK1 IL1R1 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,physical interaction ComPPI
CILK1 IL1R1 25348397 N/A physical interaction ComPPI
IRAK2 IL1R1 12659850 14525934 25348397 9374458 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP3K14 IL1R1 16286467 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
MYD88 IL1R1 12659850 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TOLLIP IL1R1 10854325 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IRAK4 IL1R1 25348397 N/A physical interaction ComPPI
SIGIRR IL1R1 12925853 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TICAM2 IL1R1 12721283 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
BMPR1A IL1R1 25348397 N/A physical interaction ComPPI
MARCHF8 IL1R1 25348397 N/A physical interaction ComPPI
TNFRSF10B IL1R1 25348397 N/A physical interaction ComPPI
IL1A IL1R1 14525934 25348397 2946959 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HERPUD1 IL1R1 25348397 N/A physical interaction ComPPI
IL1B IL1R1 14525934 24234451 25348397 9062193 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct
ATP2A3 IL1R1 25348397 N/A physical interaction ComPPI
IL1R1 IL1RN 11641511 14525934 24234451 25348397 9062194 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
IL1R1 IL1F10 11278614 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
IL1R1 TOM1 25348397 N/A physical interaction ComPPI
IL1R1 TUBB8 25348397 N/A physical interaction ComPPI
IL1R1 MFAP3 25348397 N/A physical interaction ComPPI
PELI1 IL1R1 25348397 N/A physical interaction ComPPI
MYH10 IL1R1 24234451 30021884 physical association cross-linking study IntAct
MATR3 IL1R1 24234451 30021884 physical association cross-linking study IntAct
IL1R1 MAPK10 27898060 9625767 stimulant N/A OmniPath
IL1R1 MAPK9 27898060 9625767 stimulant N/A OmniPath
IL1R1 TRAF6 12242293 12496252 12609980 15866876 16286016 16286467 16354686 20064081 27898060 stimulant N/A OmniPath
IL1R1 AKT1 12906710 27898060 N/A N/A OmniPath
IL1R1 MYD88 10217414 10854325 12609980 12659850 15866876 15905496 16286016 16354686 17507369 19940113 22904187 24735611 27898060 9374458 9430229 9575168 stimulant N/A OmniPath
MYD88 IL1R1 10217414 10854325 12609980 12659850 15866876 15905496 16286016 16354686 17507369 19940113 22904187 24735611 27898060 9374458 9430229 9575168 inhibition N/A OmniPath
RAC1 IL1R1 16354686 27898060 N/A N/A OmniPath
IL1A IL1R1 19479203 27898060 2946959 7964161 8142597 9565970 stimulant N/A OmniPath
IL1R1 PIK3R1 10373529 27898060 9360994 stimulant N/A OmniPath
IL1B IL1R1 17145710 24166242 27898060 8142597 9062193 9625767 stimulant N/A OmniPath
LIMK1 IL1R1 27898060 9821957 N/A N/A OmniPath
IL1R1 MAPK8 27898060 9625767 stimulant N/A OmniPath
IL1R1 IRAK1 12242293 12609980 14625308 15866876 15905496 16024789 16286016 22904187 24735611 27898060 8599092 9374458 9426216 9430229 stimulant N/A OmniPath
IL1R1 IRAK4 12609980 15292196 15905496 17507369 27898060 N/A N/A OmniPath
IL1R1 IL1RAP 10854325 12530978 15044087 15866876 17507369 24735611 27898060 9371760 9430229 inhibition,stimulant N/A OmniPath
IL1RAP IL1R1 10854325 12530978 15044087 15866876 17507369 24735611 27898060 9371760 9430229 inhibition,stimulant N/A OmniPath
IL1R1 IL1RN 11641511 27898060 8142597 9062194 N/A N/A OmniPath
IL1RN IL1R1 11641511 27898060 8142597 9062194 inhibition N/A OmniPath
FREM1 IL1R1 19940113 27898060 N/A N/A OmniPath
IRAK2 IL1R1 12659850 27898060 9374458 N/A N/A OmniPath
IL1R1 IRAK2 12659850 27898060 9374458 stimulant N/A OmniPath
IL1R1 SIGIRR 12925853 15866876 27898060 N/A N/A OmniPath

Visualization