GENE:IL1R1
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | IL1R1 |
FullNmae | interleukin 1 receptor type 1 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:5993 |
EnsembleID | ENSG00000115594 |
Uniprot | P14778 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
IL1R1 | pyroptosis | 35990672 | As a result, CASP4, IGSF6 and IL1R1 were identified as the potential diagnostic and therapeutic targets for SCI by computational analysis, which were enriched in NF-κB and IL6-JAK-STATA3 signaling pathways. In the injured spinal cord, these three signatures were up-regulated and closely correlated with NLRP3 inflammasome formation and gasdermin D (GSDMD) -induced pyroptosis. | retulator signature |
IL1R1 | immunogenic | 37275552 | To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. | retulator signature |
IL1R1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
IL1R1 | GO:0002020,GO:0004888,GO:0004908,GO:0004908,GO:0004909,GO:0005161,GO:0005515,GO:0005576,GO:0005886,GO:0005886,GO:0006954,GO:0006955,GO:0007166,GO:0009897,GO:0016020,GO:0019966,GO:0032729,GO:0050135,GO:0050727,GO:0061809,GO:0070498,GO:0070498,GO:0070555,GO:2000391,GO:2000556,GO:2000661 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
IL1R1 | hsa:3554 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
IL1R1 | hsa:3554 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
IL1R1 | hsa:3554 | path:hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
IL1R1 | hsa:3554 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
IL1R1 | hsa:3554 | path:hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
IL1R1 | hsa:3554 | path:hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
IL1R1 | hsa:3554 | path:hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
IL1R1 | hsa:3554 | path:hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
IL1R1 | hsa:3554 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
IL1R1 | hsa:3554 | path:hsa05146 | Amoebiasis - Homo sapiens (human) |
IL1R1 | hsa:3554 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
IL1R1 | hsa:3554 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
IL1R1 | hsa:3554 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
IL1R1 | IL1RAP | 11274345 12620219 12682231 14660645 15866876 16878026 17704786 17942936 18977329 19104081 19161412 23180781 23202296 23681101 23811849 24727385 26192618 9371760 9430229 | association,physical association | anti tag coimmunoprecipitation | ACSN,InnateDB |
IRAK4 | IL1R1 | 11274345 12609980 12620219 12682231 14660645 16878026 17704786 18977329 19161412 23180781 23681101 23811849 26192618 | interaction type,physical association | anti tag coimmunoprecipitation | ACSN,InnateDB |
MYD88 | IL1R1 | 11274345 12609980 12620219 12659850 12682231 12738796 14660645 15125833 15905496 16252010 16286016 16354686 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 19940113 21614932 23070005 23180781 23681101 23811849 26192618 | interaction type,physical association | anti tag coimmunoprecipitation,gst pull down | ACSN,InnateDB |
IL1R1 | IRAK1 | 11274345 12242293 12609980 12620219 12682231 12738796 14625308 14660645 15125833 15866876 15905496 16252010 16286016 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23180781 23331499 23681101 23811849 26192618 9374458 9430229 | interaction type,stimulation,physical association | anti tag coimmunoprecipitation | ACSN,InnateDB,SignaLink |
TRAF6 | IL1R1 | 11274345 12242293 12609980 12620219 12738796 14660645 15125833 16252010 16286016 16354686 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23180781 23681101 23811849 26192618 | interaction type,physical association | anti tag coimmunoprecipitation | ACSN,InnateDB |
IL1R1 | MAP2K6 | 11274345 12620219 12738796 14660645 15125833 16252010 16878026 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 23070005 23681101 23811849 26192618 | interaction type | N/A | ACSN |
IRAK2 | IL1R1 | 12659850 23180781 9374458 | physical association | anti tag coimmunoprecipitation,gst pull down | InnateDB |
TMED7 | IL1R1 | 12721283 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
IL1R1 | MYD88 | 15866876 23180781 9430229 | physical association | anti tag coimmunoprecipitation | InnateDB |
IL1RAP | IL1R1 | 12530978 15044087 23180781 23331499 9371760 | stimulation,physical association | anti tag coimmunoprecipitation | InnateDB,SignaLink |
AKT1 | IL1R1 | 12906710 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
IL1R1 | SIGIRR | 15866876 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
IL1R1 | TRAF6 | 15866876 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
RAC1 | IL1R1 | 16354686 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
IL1R1 | IL1RN | 23180781 8142597 | physical association | chromatography technology | InnateDB |
IL1R1 | IL1B | 23180781 8142597 | physical association | chromatography technology | InnateDB |
IL1R1 | IL1A | 23180781 8142597 | physical association | chromatography technology | InnateDB |
SIGIRR | IL1R1 | 15866876 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
FREM1 | IL1R1 | 19940113 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
EGR1 | IL1R1 | 19032775 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
TBX21 | IL1R1 | 23180781 23232398 | physical association | anti tag coimmunoprecipitation | InnateDB |
GATA3 | IL1R1 | 23180781 23232398 | physical association | anti tag coimmunoprecipitation | InnateDB |
IL1R1 | IRAK4 | 15905496 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
IL1R1 | IL1R1 | 10217414 10854325 14625308 26467481 | interaction type,bind,up-regulates activity | N/A | Signor |
IL1B | IL1R1 | 23331499 9062193 | stimulation | N/A | SignaLink,SignaLink |
IL1R1 | IRAK2 | 23331499 9374458 | stimulation | N/A | SignaLink |
IL1A | IL1R1 | 23331499 2946959 9565970 | stimulation | N/A | SignaLink |
IL1R1 | PIK3R1 | 23331499 9360994 | stimulation | N/A | SignaLink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
ESR1 | IL1R1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
GATA1 | IL1R1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
GATA2 | IL1R1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
GATA3 | IL1R1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
FOXA1 | IL1R1 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
SMARCA4 | IL1R1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | IL1R1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | IL1R1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | IL1R1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | IL1R1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
RUNX1 | IL1R1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SPI1 | IL1R1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TRIM28 | IL1R1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TAL1 | IL1R1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
ZNF263 | IL1R1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
STAT1 | IL1R1 | 15972639 | trascriptional regulation,stimulation | inferred by curator | TFlink |
STAT6 | IL1R1 | 8757327 | trascriptional regulation,stimulation | inferred by curator | TFlink |
NFKB1 | IL1R1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
RELA | IL1R1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS00000F4AC3 | IL1R1 | 16822819 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS00000F31F4 | IL1R1 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS00000B59A2 | IL1R1 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS0000236310 | IL1R1 | 25416803 28389653 | mrna cleavage,inhibition | quantitative reverse transcription pcr | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
IL1R1 | IL1A | 25361965 | interaction type | N/A | PTMCode2 |
IL1A | IL1R1 | 25361965 | interaction type | N/A | PTMCode2 |
IL1R1 | IL1B | 25361965 | interaction type | N/A | PTMCode2 |
IL1B | IL1R1 | 25361965 | interaction type | N/A | PTMCode2 |
IL1R1 | PIK3R1 | 25361965 | interaction type | N/A | PTMCode2 |
PIK3R1 | IL1R1 | 25361965 | interaction type | N/A | PTMCode2 |
IL1R1 | TOLLIP | 25361965 | interaction type | N/A | PTMCode2 |
TOLLIP | IL1R1 | 25361965 | interaction type | N/A | PTMCode2 |
IL1R1 | TRAF6 | 25361965 | interaction type | N/A | PTMCode2 |
TRAF6 | IL1R1 | 25361965 | interaction type | N/A | PTMCode2 |
IL1R1 | IRAK1 | 25361965 | interaction type | N/A | PTMCode2 |
IRAK1 | IL1R1 | 25361965 | interaction type | N/A | PTMCode2 |
IL1R1 | MYD88 | 25361965 | interaction type | N/A | PTMCode2 |
MYD88 | IL1R1 | 25361965 | interaction type | N/A | PTMCode2 |
IL1RAP | IL1R1 | 25361965 | interaction type | N/A | PTMCode2 |
IL1R1 | IL1RAP | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
TRAF6 | IL1R1 | 16286467 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
PIK3R1 | IL1R1 | 10373529 14525934 25348397 9360994 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
PDGFRB | IL1R1 | 16477012 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
IL1RAP | IL1R1 | 14525934 20802483 22426547 24234451 25348397 9371760 | physical association | experimental interaction detection,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
IRAK1 | IL1R1 | 25348397 | N/A | coimmunoprecipitation,experimental interaction detection,physical interaction,physical interaction | ComPPI |
CILK1 | IL1R1 | 25348397 | N/A | physical interaction | ComPPI |
IRAK2 | IL1R1 | 12659850 14525934 25348397 9374458 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
MAP3K14 | IL1R1 | 16286467 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
MYD88 | IL1R1 | 12659850 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
TOLLIP | IL1R1 | 10854325 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
IRAK4 | IL1R1 | 25348397 | N/A | physical interaction | ComPPI |
SIGIRR | IL1R1 | 12925853 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
TICAM2 | IL1R1 | 12721283 14525934 24234451 25348397 | physical association | coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,IntAct |
BMPR1A | IL1R1 | 25348397 | N/A | physical interaction | ComPPI |
MARCHF8 | IL1R1 | 25348397 | N/A | physical interaction | ComPPI |
TNFRSF10B | IL1R1 | 25348397 | N/A | physical interaction | ComPPI |
IL1A | IL1R1 | 14525934 25348397 2946959 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
HERPUD1 | IL1R1 | 25348397 | N/A | physical interaction | ComPPI |
IL1B | IL1R1 | 14525934 24234451 25348397 9062193 | N/A | experimental interaction detection,x-ray crystallography,physical interaction,in vitro | ComPPI,HPRD,IntAct |
ATP2A3 | IL1R1 | 25348397 | N/A | physical interaction | ComPPI |
IL1R1 | IL1RN | 11641511 14525934 24234451 25348397 9062194 | N/A | experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
IL1R1 | IL1F10 | 11278614 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
IL1R1 | TOM1 | 25348397 | N/A | physical interaction | ComPPI |
IL1R1 | TUBB8 | 25348397 | N/A | physical interaction | ComPPI |
IL1R1 | MFAP3 | 25348397 | N/A | physical interaction | ComPPI |
PELI1 | IL1R1 | 25348397 | N/A | physical interaction | ComPPI |
MYH10 | IL1R1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
MATR3 | IL1R1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
IL1R1 | MAPK10 | 27898060 9625767 | stimulant | N/A | OmniPath |
IL1R1 | MAPK9 | 27898060 9625767 | stimulant | N/A | OmniPath |
IL1R1 | TRAF6 | 12242293 12496252 12609980 15866876 16286016 16286467 16354686 20064081 27898060 | stimulant | N/A | OmniPath |
IL1R1 | AKT1 | 12906710 27898060 | N/A | N/A | OmniPath |
IL1R1 | MYD88 | 10217414 10854325 12609980 12659850 15866876 15905496 16286016 16354686 17507369 19940113 22904187 24735611 27898060 9374458 9430229 9575168 | stimulant | N/A | OmniPath |
MYD88 | IL1R1 | 10217414 10854325 12609980 12659850 15866876 15905496 16286016 16354686 17507369 19940113 22904187 24735611 27898060 9374458 9430229 9575168 | inhibition | N/A | OmniPath |
RAC1 | IL1R1 | 16354686 27898060 | N/A | N/A | OmniPath |
IL1A | IL1R1 | 19479203 27898060 2946959 7964161 8142597 9565970 | stimulant | N/A | OmniPath |
IL1R1 | PIK3R1 | 10373529 27898060 9360994 | stimulant | N/A | OmniPath |
IL1B | IL1R1 | 17145710 24166242 27898060 8142597 9062193 9625767 | stimulant | N/A | OmniPath |
LIMK1 | IL1R1 | 27898060 9821957 | N/A | N/A | OmniPath |
IL1R1 | MAPK8 | 27898060 9625767 | stimulant | N/A | OmniPath |
IL1R1 | IRAK1 | 12242293 12609980 14625308 15866876 15905496 16024789 16286016 22904187 24735611 27898060 8599092 9374458 9426216 9430229 | stimulant | N/A | OmniPath |
IL1R1 | IRAK4 | 12609980 15292196 15905496 17507369 27898060 | N/A | N/A | OmniPath |
IL1R1 | IL1RAP | 10854325 12530978 15044087 15866876 17507369 24735611 27898060 9371760 9430229 | inhibition,stimulant | N/A | OmniPath |
IL1RAP | IL1R1 | 10854325 12530978 15044087 15866876 17507369 24735611 27898060 9371760 9430229 | inhibition,stimulant | N/A | OmniPath |
IL1R1 | IL1RN | 11641511 27898060 8142597 9062194 | N/A | N/A | OmniPath |
IL1RN | IL1R1 | 11641511 27898060 8142597 9062194 | inhibition | N/A | OmniPath |
FREM1 | IL1R1 | 19940113 27898060 | N/A | N/A | OmniPath |
IRAK2 | IL1R1 | 12659850 27898060 9374458 | N/A | N/A | OmniPath |
IL1R1 | IRAK2 | 12659850 27898060 9374458 | stimulant | N/A | OmniPath |
IL1R1 | SIGIRR | 12925853 15866876 27898060 | N/A | N/A | OmniPath |