GENE：BRD2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | BRD2 |
| FullNmae | bromodomain containing 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1103 |
| EnsembleID | ENSG00000204256 |
| Uniprot | P25440 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| BRD2 | ferroptosis | 39324174 | Differential analysis identified 15 ferroptosis-associated genes (TNFAIP3, IL6, KLF2, EGR1, JUN, ZFP36, GDF15, CDKN1A, HSPB1, BRD2, PDK4, DUSP1, SLC2A3, DDIT3, and CXCL2) involved in renal IRI regulation. | retulator signature |
| BRD2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| BRD2 | GO:0001843,GO:0003682,GO:0004674,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0006334,GO:0006357,GO:0006468,GO:0007283,GO:0016607,GO:0070577 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | BRD2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | BRD2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | BRD2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | BRD2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | BRD2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | BRD2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | BRD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | BRD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | BRD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | BRD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | BRD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | BRD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | BRD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | BRD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | BRD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | BRD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | BRD2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| BRD7 | BRD2 | 12600283 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F2 | BRD2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | BRD2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000041FA2C | BRD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000070B1D | BRD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000017EA6A | BRD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001C3AC1 | BRD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00004E008F | BRD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00003D5391 | BRD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00005CC20C | BRD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00005651EE | BRD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000029D9F1 | BRD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000031E12 | BRD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000324096 | BRD2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000008A99 | BRD2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000029D793 | BRD2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AF45F | BRD2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002A79D1 | BRD2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS000014F13C | BRD2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00002394F5 | BRD2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AD002 | BRD2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AD2AA | BRD2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BRD2 | RFC4 | 25361965 | interaction type | N/A | PTMCode2 |
| RFC4 | BRD2 | 25361965 | interaction type | N/A | PTMCode2 |
| BRD2 | SIPA1 | 25361965 | interaction type | N/A | PTMCode2 |
| SIPA1 | BRD2 | 25361965 | interaction type | N/A | PTMCode2 |
| BRD2 | HEXIM1 | 25361965 | interaction type | N/A | PTMCode2 |
| HEXIM1 | BRD2 | 25361965 | interaction type | N/A | PTMCode2 |
| BRD2 | CDK9 | 25361965 | interaction type | N/A | PTMCode2 |
| CDK9 | BRD2 | 25361965 | interaction type | N/A | PTMCode2 |
| BRD2 | RFC5 | 25361965 | interaction type | N/A | PTMCode2 |
| RFC5 | BRD2 | 25361965 | interaction type | N/A | PTMCode2 |
| RFC2 | BRD2 | 25361965 | interaction type | N/A | PTMCode2 |
| BRD2 | RFC2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FAM90A1 | BRD2 | 25348397 | N/A | physical interaction | ComPPI |
| CDC5L | BRD2 | 20467437 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| H2BC4 | BRD2 | 25348397 | N/A | physical interaction | ComPPI |
| COX5A | BRD2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| INO80B | BRD2 | 25348397 | N/A | physical interaction | ComPPI |
| H4C1 | BRD2 | 20709061 24234451 25348397 | N/A | surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo | ComPPI,IntAct |
| TBP | BRD2 | 25348397 | N/A | physical interaction | ComPPI |
| JUN | BRD2 | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| AR | BRD2 | 24234451 24759320 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BAG1 | BRD2 | 25348397 | N/A | physical interaction | ComPPI |
| E2F1 | BRD2 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| CSNK2A1 | BRD2 | 25348397 | N/A | physical interaction | ComPPI |
| MDK | BRD2 | 25348397 | N/A | physical interaction | ComPPI |
| H2BC21 | BRD2 | 25348397 | N/A | physical interaction | ComPPI |
| E2F2 | BRD2 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| TADA3 | BRD2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CSNK2A2 | BRD2 | 23455922 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction,tandem affinity purification | ComPPI,IntAct |
| EPB41L1 | BRD2 | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | H2BU1 | 25348397 | N/A | in vitro,in vivo | ComPPI |
| BRD2 | TERF2 | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | BRD4 | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | BRD7 | 16786191 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| BRD2 | OBSL1 | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | DENND2D | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | RUVBL2 | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | H2BC11 | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | CSNK2B | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BRD2 | POLR2B | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | BRPF1 | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | TAGLN2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BRD2 | FARP1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BRD2 | NSD3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BRD2 | PWWP2B | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BRD2 | CDC14B | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | BRD3 | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | PIP4K2A | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | CAMKV | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | PES1 | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | EPB41L5 | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | ERG | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | SPOP | 25348397 | N/A | physical interaction | ComPPI |
| BRD2 | JARID2 | 24234451 25348397 27705803 | association | tandem affinity purification | ComPPI,IntAct |
| BRD2 | RUNX3 | 24229708 24234451 25348397 | colocalization,association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescence microscopy | ComPPI,IntAct |
| BRD2 | SF1 | 24234451 25348397 26420826 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| H3C1 | BRD2 | 24234451 25348397 29568061 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| BRD2 | IL7R | 23791182 24234451 | association | chromatin immunoprecipitation assay | IntAct |
| BRD2 | BCL2 | 23791182 24234451 | association | chromatin immunoprecipitation assay | IntAct |