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GENE：CTSB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CTSB
FullNmae cathepsin B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2527
EnsembleID ENSG00000164733
Uniprot P07858

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CTSB lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
CTSB lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CTSB ferroptosis 38989455 Through integrated analysis of scRNA-seq with microarray and bulk RNA sequencing data, a ferroptosis-related gene signature containing ACSL4, CTSB, and TLR4 genes that were associated with tuberculosis disease was identified. retulator signature

Go Annotation:

GeneSymbol Go id
CTSB GO:0004197,GO:0004197,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005764,GO:0005764,GO:0006508,GO:0006590,GO:0008233,GO:0008234,GO:0009897,GO:0016324,GO:0030574,GO:0030855,GO:0036021,GO:0042470,GO:0042981,GO:0043394,GO:0046697,GO:0046718,GO:0048471,GO:0051603,GO:0051603,GO:0062023,GO:0070062,GO:0097067,GO:1904090,GO:1904813

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CTSB hsa:1508 path:hsa04140 Autophagy - animal - Homo sapiens (human)
CTSB hsa:1508 path:hsa04142 Lysosome - Homo sapiens (human)
CTSB hsa:1508 path:hsa04210 Apoptosis - Homo sapiens (human)
CTSB hsa:1508 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
CTSB hsa:1508 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
CTSB hsa:1508 path:hsa04924 Renin secretion - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NFKB1 CTSB 15102937 21725609 23178297 23572150 26192618 interaction type N/A ACSN
CTSB BID 10364179 10805722 11085742 11085743 11832478 12776207 16237087 16966373 17670831 18955971 26192618 9727492 interaction type N/A ACSN
CTSB AIFM1 11278689 12776207 15590628 15775970 15933737 16237087 26192618 interaction type N/A ACSN
CTSB CCL20 16709808 23180781 cleavage reaction,protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR CTSB 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CTSB 10701774 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CTSB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CTSB 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
USF1 CTSB 14669984 15276216 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
USF2 CTSB 14669984 15276216 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
SMARCA4 CTSB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CTSB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CTSB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CTSB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CTSB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CTSB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CTSB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CTSB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CTSB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 CTSB 15102937 18598236 trascriptional regulation,stimulation inferred by curator TFlink
RELA CTSB 15102937 18598236 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CTSB 10701774 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CTSB 10701774 trascriptional regulation,stimulation inferred by curator TFlink
SP3 CTSB 10701774 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 CTSB 11556541 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000330617 CTSB 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005C1F22 CTSB 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA CTSB 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001C85C7 CTSB 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000023F008 CTSB 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 CTSB 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 CTSB 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 CTSB 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000544FF1 CTSB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000016FF9C CTSB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001D4A78 CTSB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000345DEB CTSB 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000004203C CTSB 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AMBP CTSB 25361965 interaction type N/A PTMCode2
CTSB AMBP 25361965 interaction type N/A PTMCode2
CSTB CTSB 25361965 interaction type N/A PTMCode2
CTSB CSTB 25361965 interaction type N/A PTMCode2
ACAN CTSB 25361965 interaction type N/A PTMCode2
CTSB ACAN 25361965 interaction type N/A PTMCode2
APOE CTSB 25361965 interaction type N/A PTMCode2
CTSB APOE 25361965 interaction type N/A PTMCode2
CTSD CTSB 25361965 interaction type N/A PTMCode2
CTSB CTSD 25361965 interaction type N/A PTMCode2
CTSB ANXA2 25361965 interaction type N/A PTMCode2
ANXA2 CTSB 25361965 interaction type N/A PTMCode2
CTSB SRPX2 25361965 interaction type N/A PTMCode2
SRPX2 CTSB 25361965 interaction type N/A PTMCode2
CTSB CST3 25361965 interaction type N/A PTMCode2
CST3 CTSB 25361965 interaction type N/A PTMCode2
A2M CTSB 25361965 interaction type N/A PTMCode2
CTSB A2M 25361965 interaction type N/A PTMCode2
CSTA CTSB 25361965 interaction type N/A PTMCode2
CTSB CSTA 25361965 interaction type N/A PTMCode2
SPHK1 CTSB 25361965 interaction type N/A PTMCode2
CTSB SPHK1 25361965 interaction type N/A PTMCode2
REN CTSB 25361965 interaction type N/A PTMCode2
CTSB REN 25361965 interaction type N/A PTMCode2
ADAMTSL4 CTSB 25361965 interaction type N/A PTMCode2
CTSB ADAMTSL4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SPRY2 CTSB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SH3KBP1 CTSB 16733801 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SLPI CTSB 11435427 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CDKN1A CTSB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AMBP CTSB 16364318 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,pull down,fluorescence microscopy ComPPI,IntAct
HIPK4 CTSB 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PTPN18 CTSB 25348397 N/A physical interaction ComPPI
INS CTSB 14525934 25348397 27898060 6351842 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CTSB APOE 12057992 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
CTSB BGLAP 14525934 25348397 9076588 N/A experimental interaction detection,in vivo ComPPI,HPRD
CTSB ANXA2 10777578 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CTSB ACAN 1326552 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CTSB REN 14525934 1597471 2061332 25348397 3542996 9928950 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CTSB CSTA 10353845 14503883 14525934 20860624 24234451 25348397 27898060 9585570 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
CTSB CSTB 11514663 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CTSB CST7 14525934 25348397 9632704 9733783 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSB CST3 11115496 14525934 1996959 25348397 27898060 7890620 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
CTSB SERPINB13 10512713 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSB MARCKS 14525934 25348397 27898060 9295331 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CTSB CTSD 10876156 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CTSB SPHK1 14525934 15710602 17064696 24234451 25348397 cleavage reaction experimental interaction detection,protease assay,in vitro ComPPI,HPRD,IntAct
CTSB S100A10 10777578 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
CTSB BAG6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CTSB RGS2 14525934 16169070 21900206 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CTSB SPINT2 14525934 16364318 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
CTSB ADAMTSL4 14525934 16364318 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,imaging technique,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CTSB SRPX2 14525934 18718938 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
CTSB A2M 14525934 2476070 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CTSB ANXA2P2 25348397 N/A physical interaction ComPPI
CTSB UBQLN4 25348397 N/A physical interaction ComPPI
CTSB USP29 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTSB DMWD 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTSB ANXA7 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CTSB APP 25348397 N/A physical interaction ComPPI
CTSB PROCR 25348397 N/A physical interaction ComPPI
CTSB PARP1 25348397 N/A physical interaction ComPPI
CTSB MLH1 20706999 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
CTSB EEF1AKMT3 25348397 N/A physical interaction ComPPI
CTSB HNRNPD 25348397 N/A physical interaction ComPPI
CTSB XRN1 25348397 N/A physical interaction ComPPI
CTSB CDK18 25348397 N/A physical interaction ComPPI
CTSB FBXO6 25348397 N/A physical interaction ComPPI
CTSB IRS4 24234451 25036637 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTSB UNK 25348397 N/A physical interaction ComPPI
CTSB MSI2 25348397 N/A physical interaction ComPPI
CTSB HSPB2 24234451 25348397 26465331 physical association two hybrid,physical interaction ComPPI,IntAct
CTSB STK11 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CTSB CEP164 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CTSB FBF1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CTSB RPGRIP1L 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CTSB SCLT1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CTSB CDH1 25348397 N/A physical interaction ComPPI
CTSB NR3C1 25348397 N/A physical interaction ComPPI
CTSB TRIM25 25348397 N/A physical interaction ComPPI
CTSB BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
CTSB PPEF1 24234451 25348397 28330616 association pull down ComPPI,IntAct
FAM118B CTSB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CTSB PLAU 14525934 1900515 N/A experimental interaction detection HPRD
CTSB CTSB 14525934 1868826 7718586 N/A experimental interaction detection HPRD
CTSB BID 14581476 27898060 stimulant N/A OmniPath
CTSB IGF1 16051222 27898060 N/A N/A OmniPath
CTSB CCL20 16709808 27898060 N/A N/A OmniPath
CTSB REN 1597471 2061332 27898060 3542996 9928950 N/A N/A OmniPath
CTSB BGLAP 27898060 9076588 N/A N/A OmniPath

Visualization










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