GENE:CTSB
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | CTSB |
FullNmae | cathepsin B |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:2527 |
EnsembleID | ENSG00000164733 |
Uniprot | P07858 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
CTSB | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
CTSB | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
CTSB | ferroptosis | 38989455 | Through integrated analysis of scRNA-seq with microarray and bulk RNA sequencing data, a ferroptosis-related gene signature containing ACSL4, CTSB, and TLR4 genes that were associated with tuberculosis disease was identified. | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
CTSB | GO:0004197,GO:0004197,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005764,GO:0005764,GO:0006508,GO:0006590,GO:0008233,GO:0008234,GO:0009897,GO:0016324,GO:0030574,GO:0030855,GO:0036021,GO:0042470,GO:0042981,GO:0043394,GO:0046697,GO:0046718,GO:0048471,GO:0051603,GO:0051603,GO:0062023,GO:0070062,GO:0097067,GO:1904090,GO:1904813 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
CTSB | hsa:1508 | path:hsa04140 | Autophagy - animal - Homo sapiens (human) |
CTSB | hsa:1508 | path:hsa04142 | Lysosome - Homo sapiens (human) |
CTSB | hsa:1508 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
CTSB | hsa:1508 | path:hsa04612 | Antigen processing and presentation - Homo sapiens (human) |
CTSB | hsa:1508 | path:hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
CTSB | hsa:1508 | path:hsa04924 | Renin secretion - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
NFKB1 | CTSB | 15102937 21725609 23178297 23572150 26192618 | interaction type | N/A | ACSN |
CTSB | BID | 10364179 10805722 11085742 11085743 11832478 12776207 16237087 16966373 17670831 18955971 26192618 9727492 | interaction type | N/A | ACSN |
CTSB | AIFM1 | 11278689 12776207 15590628 15775970 15933737 16237087 26192618 | interaction type | N/A | ACSN |
CTSB | CCL20 | 16709808 23180781 | cleavage reaction,protein cleavage | protease assay | InnateDB |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | CTSB | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
ETS1 | CTSB | 10701774 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
GATA1 | CTSB | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
GATA2 | CTSB | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
USF1 | CTSB | 14669984 15276216 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
USF2 | CTSB | 14669984 15276216 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
SMARCA4 | CTSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | CTSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | CTSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | CTSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | CTSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | CTSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | CTSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SPI1 | CTSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TP53 | CTSB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
NFKB1 | CTSB | 15102937 18598236 | trascriptional regulation,stimulation | inferred by curator | TFlink |
RELA | CTSB | 15102937 18598236 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SP1 | CTSB | 10701774 | trascriptional regulation,stimulation | inferred by curator | TFlink |
DAND5 | CTSB | 10701774 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SP3 | CTSB | 10701774 | trascriptional regulation,stimulation | inferred by curator | TFlink |
STAT1 | CTSB | 11556541 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS0000330617 | CTSB | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS00005C1F22 | CTSB | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000C5BAA | CTSB | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001C85C7 | CTSB | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000023F008 | CTSB | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000007F792 | CTSB | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000272039 | CTSB | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00005E1A16 | CTSB | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000544FF1 | CTSB | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000016FF9C | CTSB | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001D4A78 | CTSB | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000345DEB | CTSB | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000004203C | CTSB | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AMBP | CTSB | 25361965 | interaction type | N/A | PTMCode2 |
CTSB | AMBP | 25361965 | interaction type | N/A | PTMCode2 |
CSTB | CTSB | 25361965 | interaction type | N/A | PTMCode2 |
CTSB | CSTB | 25361965 | interaction type | N/A | PTMCode2 |
ACAN | CTSB | 25361965 | interaction type | N/A | PTMCode2 |
CTSB | ACAN | 25361965 | interaction type | N/A | PTMCode2 |
APOE | CTSB | 25361965 | interaction type | N/A | PTMCode2 |
CTSB | APOE | 25361965 | interaction type | N/A | PTMCode2 |
CTSD | CTSB | 25361965 | interaction type | N/A | PTMCode2 |
CTSB | CTSD | 25361965 | interaction type | N/A | PTMCode2 |
CTSB | ANXA2 | 25361965 | interaction type | N/A | PTMCode2 |
ANXA2 | CTSB | 25361965 | interaction type | N/A | PTMCode2 |
CTSB | SRPX2 | 25361965 | interaction type | N/A | PTMCode2 |
SRPX2 | CTSB | 25361965 | interaction type | N/A | PTMCode2 |
CTSB | CST3 | 25361965 | interaction type | N/A | PTMCode2 |
CST3 | CTSB | 25361965 | interaction type | N/A | PTMCode2 |
A2M | CTSB | 25361965 | interaction type | N/A | PTMCode2 |
CTSB | A2M | 25361965 | interaction type | N/A | PTMCode2 |
CSTA | CTSB | 25361965 | interaction type | N/A | PTMCode2 |
CTSB | CSTA | 25361965 | interaction type | N/A | PTMCode2 |
SPHK1 | CTSB | 25361965 | interaction type | N/A | PTMCode2 |
CTSB | SPHK1 | 25361965 | interaction type | N/A | PTMCode2 |
REN | CTSB | 25361965 | interaction type | N/A | PTMCode2 |
CTSB | REN | 25361965 | interaction type | N/A | PTMCode2 |
ADAMTSL4 | CTSB | 25361965 | interaction type | N/A | PTMCode2 |
CTSB | ADAMTSL4 | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
SPRY2 | CTSB | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
SH3KBP1 | CTSB | 16733801 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
SLPI | CTSB | 11435427 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
CDKN1A | CTSB | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
AMBP | CTSB | 16364318 24234451 25348397 | colocalization,physical association | anti tag coimmunoprecipitation,two hybrid,pull down,fluorescence microscopy | ComPPI,IntAct |
HIPK4 | CTSB | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
PTPN18 | CTSB | 25348397 | N/A | physical interaction | ComPPI |
INS | CTSB | 14525934 25348397 27898060 6351842 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
CTSB | APOE | 12057992 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
CTSB | BGLAP | 14525934 25348397 9076588 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
CTSB | ANXA2 | 10777578 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
CTSB | ACAN | 1326552 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
CTSB | REN | 14525934 1597471 2061332 25348397 3542996 9928950 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
CTSB | CSTA | 10353845 14503883 14525934 20860624 24234451 25348397 27898060 9585570 | N/A | experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct,OmniPath |
CTSB | CSTB | 11514663 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
CTSB | CST7 | 14525934 25348397 9632704 9733783 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
CTSB | CST3 | 11115496 14525934 1996959 25348397 27898060 7890620 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
CTSB | SERPINB13 | 10512713 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
CTSB | MARCKS | 14525934 25348397 27898060 9295331 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
CTSB | CTSD | 10876156 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
CTSB | SPHK1 | 14525934 15710602 17064696 24234451 25348397 | cleavage reaction | experimental interaction detection,protease assay,in vitro | ComPPI,HPRD,IntAct |
CTSB | S100A10 | 10777578 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
CTSB | BAG6 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
CTSB | RGS2 | 14525934 16169070 21900206 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
CTSB | SPINT2 | 14525934 16364318 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD |
CTSB | ADAMTSL4 | 14525934 16364318 24234451 25348397 | colocalization,physical association | anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,imaging technique,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
CTSB | SRPX2 | 14525934 18718938 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD |
CTSB | A2M | 14525934 2476070 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
CTSB | ANXA2P2 | 25348397 | N/A | physical interaction | ComPPI |
CTSB | UBQLN4 | 25348397 | N/A | physical interaction | ComPPI |
CTSB | USP29 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
CTSB | DMWD | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
CTSB | ANXA7 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
CTSB | APP | 25348397 | N/A | physical interaction | ComPPI |
CTSB | PROCR | 25348397 | N/A | physical interaction | ComPPI |
CTSB | PARP1 | 25348397 | N/A | physical interaction | ComPPI |
CTSB | MLH1 | 20706999 24234451 25348397 | colocalization,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy | ComPPI,IntAct |
CTSB | EEF1AKMT3 | 25348397 | N/A | physical interaction | ComPPI |
CTSB | HNRNPD | 25348397 | N/A | physical interaction | ComPPI |
CTSB | XRN1 | 25348397 | N/A | physical interaction | ComPPI |
CTSB | CDK18 | 25348397 | N/A | physical interaction | ComPPI |
CTSB | FBXO6 | 25348397 | N/A | physical interaction | ComPPI |
CTSB | IRS4 | 24234451 25036637 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
CTSB | UNK | 25348397 | N/A | physical interaction | ComPPI |
CTSB | MSI2 | 25348397 | N/A | physical interaction | ComPPI |
CTSB | HSPB2 | 24234451 25348397 26465331 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
CTSB | STK11 | 24234451 25348397 25640309 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
CTSB | CEP164 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
CTSB | FBF1 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
CTSB | RPGRIP1L | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
CTSB | SCLT1 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
CTSB | CDH1 | 25348397 | N/A | physical interaction | ComPPI |
CTSB | NR3C1 | 25348397 | N/A | physical interaction | ComPPI |
CTSB | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
CTSB | BCAR1 | 24234451 25348397 28007913 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
CTSB | PPEF1 | 24234451 25348397 28330616 | association | pull down | ComPPI,IntAct |
FAM118B | CTSB | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
CTSB | PLAU | 14525934 1900515 | N/A | experimental interaction detection | HPRD |
CTSB | CTSB | 14525934 1868826 7718586 | N/A | experimental interaction detection | HPRD |
CTSB | BID | 14581476 27898060 | stimulant | N/A | OmniPath |
CTSB | IGF1 | 16051222 27898060 | N/A | N/A | OmniPath |
CTSB | CCL20 | 16709808 27898060 | N/A | N/A | OmniPath |
CTSB | REN | 1597471 2061332 27898060 3542996 9928950 | N/A | N/A | OmniPath |
CTSB | BGLAP | 27898060 9076588 | N/A | N/A | OmniPath |