GENE：CTSK
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CTSK |
| FullNmae | cathepsin K |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2536 |
| EnsembleID | ENSG00000143387 |
| Uniprot | P43235 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CTSK | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| CTSK | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CTSK | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CTSK | autophagy | 32900814 | Furthermore, CtsK was implicated as an imperative regulator of the autophagy pathway in RA and macrophages. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CTSK | GO:0000422,GO:0001957,GO:0001968,GO:0004197,GO:0004197,GO:0004252,GO:0005515,GO:0005518,GO:0005576,GO:0005615,GO:0005615,GO:0005654,GO:0005764,GO:0005764,GO:0006508,GO:0006590,GO:0006915,GO:0006955,GO:0008234,GO:0008656,GO:0009897,GO:0010952,GO:0014070,GO:0016324,GO:0022617,GO:0030574,GO:0032868,GO:0034224,GO:0036021,GO:0043202,GO:0043231,GO:0043394,GO:0045453,GO:0045471,GO:0051603,GO:0051603,GO:0061037,GO:0071356,GO:0071560,GO:1903131,GO:2001235 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CTSK | hsa:1513 | path:hsa04142 | Lysosome - Homo sapiens (human) |
| CTSK | hsa:1513 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
| CTSK | hsa:1513 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| CTSK | hsa:1513 | path:hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| CTSK | hsa:1513 | path:hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RARRES2 | CTSK | 21715684 23180781 | cleavage reaction | enzymatic study | InnateDB |
| NFATC1 | CTSK | 15304486 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| SPI1 | CTSK | 15304486 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| CTSK | CAMP | 23180781 25884905 | cleavage reaction | protease assay | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | CTSK | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| CEBPA | CTSK | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CTSK | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CTSK | 21602817 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | CTSK | 15304486 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CTSL | CTSK | 25348397 | N/A | physical interaction | ComPPI |
| COL1A2 | CTSK | 25348397 | N/A | protease assay | ComPPI |
| ERBIN | CTSK | 25348397 | N/A | physical interaction | ComPPI |
| LIG4 | CTSK | 25348397 | N/A | physical interaction | ComPPI |
| SPARC | CTSK | 14525934 25348397 8647860 | N/A | experimental interaction detection,enzymatic study,in vitro | ComPPI,HPRD |
| KNG1 | CTSK | 12492488 14525934 25348397 7492318 9276160 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| SERPINB13 | CTSK | 12504904 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| CTSK | SERPINB3 | 14525934 25348397 9548757 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| CTSK | FGFR3 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| CTSK | ARID4B | 25348397 | N/A | physical interaction | ComPPI |
| CTSK | CTSV | 25348397 | N/A | physical interaction | ComPPI |
| C18ORF25 | CTSK | 25348397 | N/A | physical interaction | ComPPI |
| CTSK | BID | 14581476 27898060 | stimulant | N/A | OmniPath |