GENE：CYP1A2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CYP1A2 |
| FullNmae | cytochrome P450 family 1 subfamily A member 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2596 |
| EnsembleID | ENSG00000140505 |
| Uniprot | P05177 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CYP1A2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CYP1A2 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CYP1A2 | GO:0004497,GO:0004497,GO:0004497,GO:0005506,GO:0005515,GO:0005789,GO:0006706,GO:0006778,GO:0006805,GO:0006805,GO:0008203,GO:0008210,GO:0009055,GO:0009403,GO:0009791,GO:0009820,GO:0010468,GO:0016098,GO:0016491,GO:0016712,GO:0018894,GO:0019373,GO:0019899,GO:0020037,GO:0022900,GO:0030324,GO:0032259,GO:0032451,GO:0032787,GO:0034875,GO:0042178,GO:0042178,GO:0042572,GO:0042572,GO:0042759,GO:0043231,GO:0043231,GO:0045333,GO:0046222,GO:0046483,GO:0050665,GO:0070330,GO:0070989,GO:0071276,GO:0097267,GO:0101020,GO:0101021,GO:0106256 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CYP1A2 | hsa:1544 | path:hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| CYP1A2 | hsa:1544 | path:hsa00232 | Caffeine metabolism - Homo sapiens (human) |
| CYP1A2 | hsa:1544 | path:hsa00380 | Tryptophan metabolism - Homo sapiens (human) |
| CYP1A2 | hsa:1544 | path:hsa00591 | Linoleic acid metabolism - Homo sapiens (human) |
| CYP1A2 | hsa:1544 | path:hsa00830 | Retinol metabolism - Homo sapiens (human) |
| CYP1A2 | hsa:1544 | path:hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| CYP1A2 | hsa:1544 | path:hsa00982 | Drug metabolism - cytochrome P450 - Homo sapiens (human) |
| CYP1A2 | hsa:1544 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| CYP1A2 | hsa:1544 | path:hsa05204 | Chemical carcinogenesis - DNA adducts - Homo sapiens (human) |
| CYP1A2 | hsa:1544 | path:hsa05207 | Chemical carcinogenesis - receptor activation - Homo sapiens (human) |
| CYP1A2 | hsa:1544 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AHR | CYP1A2 | 17785579 21357676 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | CYP1A2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| USF1 | CYP1A2 | 12663044 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| USF2 | CYP1A2 | 12663044 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay | TFlink |
| SMARCA4 | CYP1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CYP1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CYP1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CYP1A2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CYP1A2 | 12135113 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF1A | CYP1A2 | 7723729 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | CYP1A2 | 12135113 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFIC | CYP1A2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000324096 | CYP1A2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000075D814 | CYP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075CC78 | CYP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002AA55A | CYP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001012BC | CYP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005586D0 | CYP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000170CF4 | CYP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021202F | CYP1A2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CYB5A | CYP1A2 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | CYP1A2 | 25348397 | N/A | physical interaction | ComPPI |
| PGRMC1 | CYP1A2 | 25348397 | N/A | physical interaction | ComPPI |
| CYP1A2 | ASAH1 | 25348397 | N/A | physical interaction | ComPPI |
| CORO1B | CYP1A2 | 24234451 30021884 | physical association | cross-linking study | IntAct |