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GENE：CCAR2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CCAR2
FullNmae cell cycle and apoptosis regulator 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:23360
EnsembleID ENSG00000158941
Uniprot Q8N163

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CCAR2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CCAR2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CCAR2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CCAR2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CCAR2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CCAR2 GO:0000774,GO:0000785,GO:0000993,GO:0003723,GO:0004857,GO:0004857,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005759,GO:0005819,GO:0006397,GO:0006974,GO:0007049,GO:0008380,GO:0009411,GO:0016055,GO:0019899,GO:0030308,GO:0031647,GO:0032435,GO:0032784,GO:0042752,GO:0043065,GO:0043086,GO:0043653,GO:0044609,GO:0045892,GO:0045892,GO:0048511,GO:0051082,GO:0090263,GO:0090311,GO:1902230,GO:2000003

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CCAR2 hsa:57805 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 CCAR2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A CCAR2 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 CCAR2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CCAR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CCAR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CCAR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CCAR2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SIRT1 CCAR2 23892437 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000512C88 CCAR2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000070B1D CCAR2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 CCAR2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D CCAR2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000192A75 CCAR2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000017EA6A CCAR2 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ATR CCAR2 22135298 phosphorylation N/A PhosphoSite
CCAR2 ASH2L 25361965 interaction type N/A PTMCode2
ASH2L CCAR2 25361965 interaction type N/A PTMCode2
RBBP5 CCAR2 25361965 interaction type N/A PTMCode2
CCAR2 RBBP5 25361965 interaction type N/A PTMCode2
SF3A2 CCAR2 25361965 interaction type N/A PTMCode2
CCAR2 SF3A2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
AIMP2 CCAR2 25348397 N/A physical interaction ComPPI
CIAO1 CCAR2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA8 CCAR2 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ANXA1 CCAR2 23754495 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PPP2R1A CCAR2 24234451 25348397 28330616 association pull down ComPPI,IntAct
MAGEA6 CCAR2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FOXB1 CCAR2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RAD21 CCAR2 25348397 N/A physical interaction ComPPI
KBTBD7 CCAR2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PNMA1 CCAR2 14676191 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SF3A2 CCAR2 17332742 24234451 25348397 physical association affinity chromatography technology,physical interaction ComPPI,IntAct
JUN CCAR2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 CCAR2 25348397 N/A physical interaction ComPPI
PPIL4 CCAR2 25348397 N/A physical interaction ComPPI
CUL3 CCAR2 25348397 N/A physical interaction ComPPI
PDIA6 CCAR2 25348397 N/A physical interaction ComPPI
NTRK1 CCAR2 25348397 N/A physical interaction ComPPI
KCNAB2 CCAR2 25348397 N/A physical interaction ComPPI
RPA1 CCAR2 25348397 N/A physical interaction ComPPI
ASH2L CCAR2 25348397 N/A physical interaction ComPPI
IKBKB CCAR2 14525934 14743216 24234451 25348397 physical association experimental interaction detection,tandem affinity purification ComPPI,HPRD,IntAct
MYC CCAR2 17314511 17353931 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,physical interaction,tandem affinity purification ComPPI,IntAct
PLEC CCAR2 25348397 N/A physical interaction ComPPI
NELFCD CCAR2 25348397 N/A physical interaction ComPPI
EEF1A1 CCAR2 25348397 N/A physical interaction ComPPI
PRMT5 CCAR2 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
IQGAP1 CCAR2 25348397 N/A physical interaction ComPPI
CFTR CCAR2 25348397 N/A physical interaction ComPPI
RELA CCAR2 25348397 N/A tandem affinity purification ComPPI
ANG CCAR2 24234451 25348397 28777577 association anti bait coimmunoprecipitation ComPPI,IntAct
RARS1 CCAR2 25348397 N/A physical interaction ComPPI
XPO1 CCAR2 25348397 N/A physical interaction ComPPI
RPA2 CCAR2 25348397 N/A physical interaction ComPPI
RPA3 CCAR2 25348397 N/A physical interaction ComPPI
QARS1 CCAR2 25348397 N/A physical interaction ComPPI
RBBP5 CCAR2 25348397 N/A physical interaction ComPPI
CCNA1 CCAR2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MTMR11 CCAR2 25348397 N/A physical interaction ComPPI
CBFA2T2 CCAR2 24234451 25348397 27281218 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NFKBIB CCAR2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MDM2 CCAR2 25348397 N/A physical interaction ComPPI
SOX2 CCAR2 25348397 N/A physical interaction ComPPI
EGFR CCAR2 24189400 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TUBA1A CCAR2 25348397 N/A physical interaction ComPPI
VHL CCAR2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CHEK2 CCAR2 25348397 N/A physical interaction ComPPI
CDK7 CCAR2 25348397 N/A physical interaction ComPPI
POLR2A CCAR2 17314511 24234451 25348397 physical association cosedimentation through density gradient ComPPI,IntAct
PPP2R2A CCAR2 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
SIRT1 CCAR2 18235501 18235502 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,molecular sieving,pull down,physical interaction ComPPI,IntAct
VCAM1 CCAR2 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
ITGA4 CCAR2 25348397 N/A physical interaction ComPPI
HIF1AN CCAR2 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
MAGED1 CCAR2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TAB2 CCAR2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HTRA2 CCAR2 25348397 N/A physical interaction ComPPI
EIF2S3 CCAR2 25348397 N/A physical interaction ComPPI
NLGN3 CCAR2 25348397 N/A physical interaction ComPPI
HDAC5 CCAR2 25348397 N/A physical interaction ComPPI
BCOR CCAR2 24234451 25348397 27505670 association tandem affinity purification ComPPI,IntAct
CDK9 CCAR2 25348397 N/A physical interaction ComPPI
NFKB2 CCAR2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ANKRA2 CCAR2 25348397 N/A physical interaction ComPPI
HDAC9 CCAR2 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EMSY CCAR2 25348397 N/A physical interaction ComPPI
TRADD CCAR2 14743216 24234451 25348397 30561431 association,physical association tandem affinity purification,virotrap ComPPI,IntAct
FOXH1 CCAR2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
PSME3 CCAR2 25348397 N/A physical interaction ComPPI
COPG1 CCAR2 25348397 N/A physical interaction ComPPI
PSMC1 CCAR2 25348397 N/A physical interaction ComPPI
BRCA1 CCAR2 25348397 N/A physical interaction ComPPI
MAP3K3 CCAR2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PSMA4 CCAR2 25348397 N/A physical interaction ComPPI
SOD1 CCAR2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PPEF1 CCAR2 24234451 25348397 28330616 association pull down ComPPI,IntAct
NCAPG CCAR2 25348397 N/A physical interaction ComPPI
NEK6 CCAR2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
GBF1 CCAR2 25348397 N/A physical interaction ComPPI
BAG2 CCAR2 22365833 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
IKBKE CCAR2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DCTN3 CCAR2 25348397 N/A physical interaction ComPPI
CNOT1 CCAR2 25348397 N/A physical interaction ComPPI
MAX CCAR2 17314511 24234451 25348397 physical association cosedimentation through density gradient ComPPI,IntAct
TARDBP CCAR2 25348397 N/A physical interaction ComPPI
ZNF335 CCAR2 25348397 N/A physical interaction ComPPI
SF3B3 CCAR2 25348397 N/A physical interaction ComPPI
SMC4 CCAR2 25348397 N/A physical interaction ComPPI
NCAPD2 CCAR2 25348397 N/A physical interaction ComPPI
RUVBL2 CCAR2 25348397 N/A physical interaction ComPPI
HSPD1 CCAR2 25348397 N/A physical interaction ComPPI
MCM7 CCAR2 17314511 24234451 25348397 physical association cosedimentation through density gradient ComPPI,IntAct
FOXP3 CCAR2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
EEF1E1 CCAR2 25348397 N/A physical interaction ComPPI
KAT8 CCAR2 25348397 N/A physical interaction ComPPI
HSD17B10 CCAR2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HNRNPA1 CCAR2 25348397 N/A physical interaction ComPPI
MCC CCAR2 25348397 N/A physical interaction ComPPI
RELB CCAR2 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CYLD CCAR2 25348397 N/A physical interaction ComPPI
TUBB3 CCAR2 25348397 N/A physical interaction ComPPI
SIRT6 CCAR2 25348397 N/A physical interaction ComPPI
POU5F1 CCAR2 25348397 N/A physical interaction ComPPI
CEP170 CCAR2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SIRT7 CCAR2 25348397 N/A physical interaction ComPPI
PPP2R2D CCAR2 24234451 25348397 28330616 association pull down,proximity-dependent biotin identification ComPPI,IntAct
ACTR3B CCAR2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SEC16A CCAR2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PTP4A3 CCAR2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MC1R CCAR2 25348397 N/A physical interaction ComPPI
FN1 CCAR2 25348397 N/A physical interaction ComPPI
EEF1A1P5 CCAR2 25348397 N/A physical interaction ComPPI
TP53 CCAR2 18235501 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GSTK1 CCAR2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD3 CCAR2 25348397 N/A physical interaction ComPPI
WRAP73 CCAR2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP4R3A CCAR2 25348397 N/A physical interaction ComPPI
RAB5IF CCAR2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CCAR2 MEPCE 25348397 N/A physical interaction ComPPI
CCAR2 EEF1AKMT3 25348397 N/A physical interaction ComPPI
CCAR2 METTL23 25348397 N/A physical interaction ComPPI
CCAR2 AIMP1 25348397 N/A physical interaction ComPPI
CCAR2 EIF2S3B 25348397 N/A physical interaction ComPPI
CCAR2 RPL27A 25348397 N/A physical interaction ComPPI
CCAR2 SMC2 25348397 N/A physical interaction ComPPI
CCAR2 ZBTB1 25348397 N/A physical interaction ComPPI
CCAR2 OBSL1 25348397 N/A physical interaction ComPPI
CCAR2 CCDC8 25348397 N/A physical interaction ComPPI
CCAR2 HSPA1L 25348397 N/A physical interaction ComPPI
CCAR2 HAO1 25348397 N/A physical interaction ComPPI
CCAR2 TUBB8 25348397 N/A physical interaction ComPPI
CCAR2 B9D2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CCAR2 FOXQ1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CCAR2 MEX3C 25348397 N/A physical interaction ComPPI
CCAR2 NANOGP8 25348397 N/A physical interaction ComPPI
CCAR2 NANOG 25348397 N/A physical interaction ComPPI
CCAR2 RC3H1 25348397 N/A physical interaction ComPPI
CCAR2 EIPR1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CCAR2 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CCAR2 ZNF121 17314511 24234451 25348397 physical association cosedimentation through density gradient ComPPI,IntAct
CCAR2 PPP2R2B 25348397 N/A anti tag coimmunoprecipitation ComPPI
CCAR2 CEP170P1 20360068 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,tandem affinity purification ComPPI,IntAct
CCAR2 PYHIN1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
CCAR2 KATNAL2 24234451 25348397 26929214 association tandem affinity purification ComPPI,IntAct
CCAR2 NBEAL2 24234451 25348397 29187380 association tandem affinity purification ComPPI,IntAct
METTL3 CCAR2 24234451 29507755 association anti tag coimmunoprecipitation IntAct
CCAR2 SMPDL3A 12442002 27898060 N/A N/A OmniPath
ATR CCAR2 24126058 27898060 N/A N/A OmniPath

Visualization










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