Gene Information gene info

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GENE：ELANE

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ELANE
FullNmae elastase, neutrophil expressed
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3309
EnsembleID ENSG00000197561
Uniprot P08246

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ELANE pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ELANE pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
ELANE netotic_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. retulator signature
ELANE netotic_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
ELANE immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ELANE ferroptosis 40204709 In this study, we used mice of Elane-knockout (Elane-KO) and wild-type (WT), and their primary mouse hepatocytes to establish MAFLD models in vivo and vitro for elucidating the role of Elane in ferroptosis of hepatocytes and MAFLD development. retulator signature

Go Annotation:

GeneSymbol Go id
ELANE GO:0000122,GO:0001878,GO:0002020,GO:0002438,GO:0002523,GO:0002812,GO:0003714,GO:0004175,GO:0004252,GO:0004252,GO:0004252,GO:0004252,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005737,GO:0005829,GO:0006508,GO:0006508,GO:0006874,GO:0006909,GO:0008201,GO:0008233,GO:0009411,GO:0009986,GO:0017053,GO:0019955,GO:0022617,GO:0030141,GO:0030163,GO:0032496,GO:0032682,GO:0032717,GO:0032757,GO:0035578,GO:0035580,GO:0042742,GO:0043406,GO:0045335,GO:0048661,GO:0050728,GO:0050778,GO:0050922,GO:0062023,GO:0070062,GO:0070269,GO:0070945,GO:0070947,GO:1903238

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ELANE hsa:1991 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
ELANE hsa:1991 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
ELANE hsa:1991 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ELANE CAMP 11389039 23180781 cleavage reaction protease assay InnateDB
ELANE CXCL8 23180781 9029135 protein cleavage protease assay InnateDB
ELANE ELN 10471600 10544250 23180781 physical association solid phase assay InnateDB
ELANE FCGRT 19506020 23180781 physical association two hybrid InnateDB
ELANE COL4A2 19506020 23180781 physical association two hybrid InnateDB
ELANE C1QA 19506020 23180781 physical association two hybrid InnateDB
ELANE C1QC 19506020 23180781 physical association two hybrid InnateDB
ELANE A2M 19506020 23180781 physical association two hybrid InnateDB
ELANE MT-CO2 19506020 23180781 physical association two hybrid InnateDB
ELANE MT-CO3 19506020 23180781 physical association two hybrid InnateDB
ELANE COX5A 19506020 23180781 physical association two hybrid InnateDB
ELANE COX5B 19506020 23180781 physical association two hybrid InnateDB
ELANE GAMT 19506020 23180781 physical association two hybrid InnateDB
ELANE VPS29 19506020 23180781 physical association two hybrid InnateDB
AZU1 ELANE 19506020 23180781 physical association two hybrid InnateDB
ELANE CTSD 19506020 23180781 physical association two hybrid InnateDB
ELANE CHIT1 19506020 23180781 physical association two hybrid InnateDB
ELANE N4BP2L2 19506020 23180781 physical association two hybrid InnateDB
ELANE DTX2 19506020 23180781 physical association two hybrid InnateDB
ELANE TLE5 19506020 23180781 physical association two hybrid InnateDB
ELANE ACLY 19506020 23180781 physical association two hybrid InnateDB
ELANE PIGA 19506020 23180781 physical association two hybrid InnateDB
ELANE ALAS2 19506020 23180781 physical association two hybrid InnateDB
ELANE GBA2 19506020 23180781 physical association two hybrid InnateDB
ELANE UROD 19506020 23180781 physical association two hybrid InnateDB
ELANE HSPD1 19506020 23180781 physical association two hybrid InnateDB
ELANE DCAF7 19506020 23180781 physical association two hybrid InnateDB
ELANE WRAP73 19506020 23180781 physical association two hybrid InnateDB
ELANE WDR6 19506020 23180781 physical association two hybrid InnateDB
ELANE MMP9 19506020 23180781 physical association two hybrid InnateDB
GFI1 ELANE 19506020 23180781 physical association anti tag coimmunoprecipitation InnateDB
CEBPE ELANE 10233885 23180781 physical association electrophoretic mobility supershift assay InnateDB
ELANE CEBPB 18647749 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELANE EHMT2 18647749 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELANE SFTPD 22860023 23180781 cleavage reaction enzymatic study InnateDB
CCL14 ELANE 16034099 23180781 protein cleavage protease assay InnateDB
IL33 ELANE 22307629 23180781 protein cleavage mass spectrometry studies of complexes,protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
CTCF ELANE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ELANE 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ELANE 14732495 16247445 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ELANE 16247445 19620402 trascriptional regulation,stimulation inferred by curator TFlink
GFI1 ELANE 18328744 trascriptional regulation,stimulation inferred by curator TFlink
LEF1 ELANE 14594802 19620402 trascriptional regulation,stimulation inferred by curator TFlink
MYB ELANE 16247445 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ELANE 16247445 trascriptional regulation,stimulation inferred by curator TFlink
RUNX2 ELANE 14594802 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
SLPI ELANE 10702419 14525934 18421166 24234451 25348397 N/A experimental interaction detection,x-ray crystallography,in vitro ComPPI,HPRD,IntAct
SERPINA3 ELANE 14525934 25348397 27898060 8011628 8718849 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
ELANE ITGAM 14525934 15718918 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ELANE CSF3 14525934 14587040 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELANE CSF3R 14525934 14587040 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELANE CXCR4 12531874 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELANE VCAM1 11520773 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELANE CXCL12 12068293 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ELANE TGFA 14525934 15245434 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ELANE F2RL1 10978167 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELANE F2R 10978167 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELANE SERPINB1 10924364 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
ELANE ELN 10471600 10544250 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ELANE GRN 12526812 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ELANE LPA 25348397 N/A in vitro ComPPI
ELANE TFPI 10859319 12117418 14525934 1558967 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ELANE SERPINE1 14525934 25348397 7521069 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELANE SDC1 14525934 25348397 9565572 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELANE THBS1 14525934 25348397 8463250 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ELANE F5 14525934 25348397 27898060 9242537 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ELANE KNG1 12887060 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ELANE SERPINF2 14525934 2437112 25348397 6980881 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ELANE SERPINA1 10867014 14525934 16321984 24234451 25348397 27898060 N/A experimental interaction detection,physical interaction,comigration in non denaturing gel electrophoresis,in vitro ComPPI,HPRD,IntAct,OmniPath
ELANE CAMP 25348397 N/A in vitro ComPPI
ELANE SERPINB13 10512713 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELANE SERPING1 14525934 25348397 6980881 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ELANE YARS1 10102815 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ELANE NOTCH2NLA 14525934 14673143 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
ELANE LRP1 14525934 15131125 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ELANE GZMB 24234451 25348397 27898060 9404514 physical association x-ray crystallography,x ray scattering ComPPI,IntAct,OmniPath
ELANE ELANE 12190311 14525934 N/A experimental interaction detection HPRD
ELANE SERPIND1 14525934 2318847 N/A experimental interaction detection HPRD
ELANE CXCL8 27898060 9029135 stimulant N/A OmniPath
ELANE IL33 22307629 27898060 N/A N/A OmniPath
CEBPA ELANE 15676205 27898060 stimulant N/A OmniPath
RUNX1 ELANE 15676205 27898060 stimulant N/A OmniPath
ELANE SERPIND1 2318847 27898060 N/A N/A OmniPath

Visualization










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