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GENE：ERAP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ERAP1
FullNmae endoplasmic reticulum aminopeptidase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18173
EnsembleID ENSG00000164307
Uniprot Q9NZ08

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ERAP1 immunogenic 36579538 Through literature reviews, a total of 108 ICD-related genes were identified (Supplement Table S1). retulator signature
ERAP1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ERAP1 GO:0001525,GO:0002250,GO:0002474,GO:0004175,GO:0004177,GO:0005138,GO:0005151,GO:0005515,GO:0005576,GO:0005615,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0005829,GO:0006508,GO:0006509,GO:0008217,GO:0008217,GO:0008235,GO:0008270,GO:0008270,GO:0009617,GO:0016020,GO:0016020,GO:0019885,GO:0019885,GO:0042277,GO:0043171,GO:0045088,GO:0045444,GO:0045766,GO:0070006,GO:0070062

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TNFRSF1A ERAP1 18445477 23180781 physical association anti tag coimmunoprecipitation InnateDB
ERAP1 RBMX 18445477 23180781 physical association anti tag coimmunoprecipitation InnateDB
NUCB2 ERAP1 16407280 23180781 physical association two hybrid InnateDB
ERAP1 TNFRSF1A 16407280 23180781 physical association anti tag coimmunoprecipitation InnateDB
ERAP1 NUCB2 16407280 23180781 physical association anti tag coimmunoprecipitation InnateDB
ERAP1 ARFGEF2 17276987 23180781 physical association anti tag coimmunoprecipitation InnateDB
ERAP1 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 ERAP1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 ERAP1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ERAP1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ERAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ERAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ERAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ERAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ERAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ERAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 ERAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ERAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ERAP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 ERAP1 20103633 trascriptional regulation,stimulation inferred by curator TFlink
RELA ERAP1 20103633 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 ERAP1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 ERAP1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000042E1F ERAP1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 ERAP1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 ERAP1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 ERAP1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA ERAP1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 ERAP1 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ERAP1 IL6R 25361965 interaction type N/A PTMCode2
IL6R ERAP1 25361965 interaction type N/A PTMCode2
TNFRSF1A ERAP1 25361965 interaction type N/A PTMCode2
ERAP1 TNFRSF1A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SLAMF1 ERAP1 25348397 N/A physical interaction ComPPI
ENO1 ERAP1 25348397 N/A physical interaction ComPPI
TNFRSF1A ERAP1 12189246 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
CFTR ERAP1 25348397 N/A physical interaction ComPPI
H3-4 ERAP1 25348397 N/A physical interaction ComPPI
ERAP1 IL6R 12748171 14525934 24234451 25348397 27898060 physical association coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct,OmniPath
ERAP1 MOV10 25348397 N/A physical interaction ComPPI
ERAP1 NXF1 25348397 N/A physical interaction ComPPI
ERAP1 HLA-DQB2 25348397 N/A physical interaction ComPPI
ERAP1 KLK11 25348397 N/A physical interaction ComPPI
ERAP1 KIR2DL3 25348397 N/A physical interaction ComPPI
ERAP1 KIR2DS2 25348397 N/A physical interaction ComPPI
ERAP1 HLA-B 25348397 N/A physical interaction ComPPI
ERAP1 P2RY8 25348397 N/A physical interaction ComPPI
ERAP1 SIAE 25348397 N/A physical interaction ComPPI
ERAP1 DHCR24 25348397 N/A physical interaction ComPPI
ERAP1 TMEM87A 25348397 N/A physical interaction ComPPI
ERAP1 APOL2 25348397 N/A physical interaction ComPPI
ERAP1 SCGB1D4 25348397 N/A physical interaction ComPPI
ERAP1 SLC16A10 25348397 N/A physical interaction ComPPI
ERAP1 ROMO1 25348397 N/A physical interaction ComPPI
ERAP1 DEFA1 25348397 N/A physical interaction ComPPI
ERAP1 EDEM3 25348397 N/A physical interaction ComPPI
MUL1 ERAP1 25348397 N/A physical interaction ComPPI
ERAP1 CSNK1G2 24234451 30021884 physical association cross-linking study IntAct
ERAP1 USP20 24234451 30021884 physical association cross-linking study IntAct
ZMYM3 ERAP1 24234451 30021884 physical association cross-linking study IntAct
TNFRSF1A ERAP1 12189246 16407280 18445477 27898060 N/A N/A OmniPath

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