Gene Information gene info

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GENE：GLB1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GLB1
FullNmae galactosidase beta 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4298
EnsembleID ENSG00000170266
Uniprot P16278

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GLB1 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
GLB1 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
GLB1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GLB1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GLB1 GO:0004565,GO:0004565,GO:0004565,GO:0004565,GO:0005515,GO:0005576,GO:0005737,GO:0005773,GO:0005794,GO:0005975,GO:0006687,GO:0016936,GO:0019388,GO:0030200,GO:0035578,GO:0042340,GO:0042803,GO:0043202,GO:0043231,GO:0048471,GO:0051413,GO:0070062,GO:1904016,GO:1904813

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GLB1 hsa:2720 path:hsa00052 Galactose metabolism - Homo sapiens (human)
GLB1 hsa:2720 path:hsa00511 Other glycan degradation - Homo sapiens (human)
GLB1 hsa:2720 path:hsa00531 Glycosaminoglycan degradation - Homo sapiens (human)
GLB1 hsa:2720 path:hsa00600 Sphingolipid metabolism - Homo sapiens (human)
GLB1 hsa:2720 path:hsa00604 Glycosphingolipid biosynthesis - ganglio series - Homo sapiens (human)
GLB1 hsa:2720 path:hsa01100 Metabolic pathways - Homo sapiens (human)
GLB1 hsa:2720 path:hsa04142 Lysosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA1 GLB1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 GLB1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 GLB1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 GLB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GLB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GLB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GLB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GLB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 GLB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GLB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GLB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GLB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GLB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 GLB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 GLB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR GLB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 GLB1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000324096 GLB1 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase

Source Target Pmid Interactiontype Methods Database
LGALS3 GLB1 25348397 N/A physical interaction ComPPI
VIM GLB1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
TK1 GLB1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VCP GLB1 25348397 N/A physical interaction ComPPI
CTNNBIP1 GLB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SLC7A1 GLB1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FZR1 GLB1 25348397 N/A physical interaction ComPPI
RHOC GLB1 25348397 N/A physical interaction ComPPI
RHOA GLB1 25348397 N/A physical interaction ComPPI
VAPA GLB1 25348397 N/A physical interaction ComPPI
PLAUR GLB1 25348397 N/A physical interaction ComPPI
PLK1 GLB1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DNAJB2 GLB1 25348397 N/A physical interaction ComPPI
PTPN7 GLB1 25348397 N/A physical interaction ComPPI
ATP6AP2 GLB1 25348397 N/A physical interaction ComPPI
ABCE1 GLB1 25348397 N/A physical interaction ComPPI
CDK2 GLB1 25348397 N/A physical interaction ComPPI
CTSA GLB1 14525934 24234451 25348397 9501080 physical association experimental interaction detection,physical interaction,in vitro,inference by socio-affinity scoring ComPPI,HPRD,IntAct
GLB1 NEU1 14525934 16314420 24234451 25348397 27898060 3102233 3922758 colocalization electron microscopy,experimental interaction detection,physical interaction,in vitro,in vivo,confocal microscopy ComPPI,HPRD,IntAct,OmniPath
GLB1 DNAJB1 14525934 25348397 27898060 8670798 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
GLB1 H2AX 20000738 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GLB1 CSNK2B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GLB1 FBXO6 25348397 N/A physical interaction ComPPI
GLB1 FOS 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GLB1 MEPCE 25348397 N/A physical interaction ComPPI
GLB1 TRAPPC9 25348397 N/A physical interaction ComPPI
GLB1 KLHDC9 25348397 N/A physical interaction ComPPI
GLB1 TRAPPC2L 25348397 N/A physical interaction ComPPI
GLB1 RORC 25348397 N/A physical interaction ComPPI
GLB1 A2M 17174955 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
GLB1 NAGK 16377628 19409905 19631611 27898060 N/A N/A OmniPath

Visualization










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